InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem
- CAS No.
- Chemical Name:
- InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem
- Synonyms
- InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem
- CBNumber:
- CB24817356
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem price More Price(1)
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 M). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
Biochem/physiol Actions
Cell permeable: yes
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem