ChemicalBook >> CAS DataBase List >>2,6-Dichlorophenylacetic acid

2,6-Dichlorophenylacetic acid

CAS No.
6575-24-2
Chemical Name:
2,6-Dichlorophenylacetic acid
Synonyms
2-(2,6-DICHLOROPHENYL)ACETIC ACID;TIMTEC-BB SBB003503;2,6-Dichlorophenyla;RARECHEM AL BO 0115;Guanfacine Impurity 1;2,6-Dichlorphenylessigsure;6-Dichlorophenylacetic acid;2,6-DICHLOROPHENYLACETIC ACID;2,6-DICHLORO BENZENEACETIC ACID;2,6-DichlorophenylaceticAcid>
CBNumber:
CB2481995
Molecular Formula:
C8H6Cl2O2
Molecular Weight:
205.04
MDL Number:
MFCD00004320
MOL File:
6575-24-2.mol
Last updated:2023-07-26 18:30:44

2,6-Dichlorophenylacetic acid Properties

Melting point 158-161 °C (lit.)
Boiling point 294.45°C (rough estimate)
Density 1.3806 (rough estimate)
refractive index 1.5490 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.80±0.10(Predicted)
color White to Off-White
BRN 1952744
InChI InChI=1S/C8H6Cl2O2/c9-6-2-1-3-7(10)5(6)4-8(11)12/h1-3H,4H2,(H,11,12)
InChIKey SFAILOOQFZNOAU-UHFFFAOYSA-N
SMILES C1(CC(O)=O)=C(Cl)C=CC=C1Cl
CAS DataBase Reference 6575-24-2(CAS DataBase Reference)
FDA UNII K8G025CX8W
NIST Chemistry Reference 2,6-Dichlorophenylacetic acid(6575-24-2)
EPA Substance Registry System Benzeneacetic acid, 2,6-dichloro- (6575-24-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26-26/37/39-36
WGK Germany  3
Hazard Note  Irritant
HS Code  29163900
NFPA 704
1
2 0

2,6-Dichlorophenylacetic acid price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 259241 2,6-Dichlorophenylacetic acid 97% 6575-24-2 25g $39.2 2023-06-20 Buy
Sigma-Aldrich 259241 2,6-Dichlorophenylacetic acid 97% 6575-24-2 100g $149 2023-06-20 Buy
TCI Chemical D1897 2,6-Dichlorophenylacetic Acid >96.0%(T) 6575-24-2 25g $133 2024-03-01 Buy
Alfa Aesar B21354 2,6-Dichlorophenylacetic acid, 98% 6575-24-2 5g $22.65 2024-03-01 Buy
Alfa Aesar B21354 2,6-Dichlorophenylacetic acid, 98% 6575-24-2 25g $59.65 2024-03-01 Buy
Product number Packaging Price Buy
259241 25g $39.2 Buy
259241 100g $149 Buy
D1897 25g $133 Buy
B21354 5g $22.65 Buy
B21354 25g $59.65 Buy

2,6-Dichlorophenylacetic acid Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells.

Preparation

The preparation of the 2, 6-dichlorophenylacetic acid:
the method comprises the following steps: 2, 6-dichlorotoluene is used as a raw material, and is catalyzed by a complex catalyst formed by transition metal and a ligand (wherein, a transition metal catalyst precursor is preferably palladium chloride, an oxidant is preferably TBP (tert-butyl peroxy ether), and a ligand is preferably Xantphos (4, 5-bis (diphenylphosphino) -9, 9-dimethyl xanthene)) in the presence of an alcohol and a catalyst and an oxidant to obtain 2, 6-dichlorophenylacetic acid, and the ethyl 2, 6-dichlorophenylacetate is prepared by hydrolysis and acidification, wherein the total yield is 68.4%. See patent document US2013303798, the reaction procedure is described as synthetic route 1.
preparation of the 2, 6-dichlorophenylacetic acid
In the above synthetic route 1, the preparation process of the intermediate ethyl 2, 6-dichlorophenylacetate requires the use of carbon monoxide for high-temperature and high-pressure reaction, and has poor operation safety, high equipment requirement, high cost, and is not favorable for cost reduction and green production of 2, 6-dichlorophenylacetic acid.

Purification Methods

Crystallise the acid from aqueous EtOH. [Beilstein 9 III 2272.]

3215-64-3
6575-24-2
Synthesis of 2,6-Dichlorophenylacetic acid from 2,6-Dichlorobenzyl acetonitrile
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View Lastest Price from 2,6-Dichlorophenylacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-Dichlorophenylacetic acid pictures 2023-11-13 2,6-Dichlorophenylacetic acid
6575-24-2
US $614.40 / Kg/Drum 1Kg/Bag 98% 10tons Wuhan Boye Science And Technology Development Co., Ltd.
2,6-Dichlorophenylacetic acid pictures 2023-09-06 2,6-Dichlorophenylacetic acid
6575-24-2
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
2,6-Dichlorophenylacetic acid  pictures 2023-05-17 2,6-Dichlorophenylacetic acid
6575-24-2
US $9.00 / KG 1KG 99.9 1 ton Hebei Guanlang Biotechnology Co,.LTD

2,6-Dichlorophenylacetic acid Spectrum

TIMTEC-BB SBB003503 Benzeneacetic acid, 2,6-dichloro- 2,6-Dichlorophenyl acetic acid 98% 2,6-Dichlorophenylacetic acid, 98+% Acetic acid, (2,6-dichlorophenyl)- 2,6-Dichlorophenylacetic acid,99% 6-Dichlorophenylacetic acid 2,6-two chlorophenyl acetic acid 2,6-Dichlorophenyla 2,6-DICHLORO BENZENEACETIC ACID 2,6-DICHLOROPHENYLACETIC ACID RARECHEM AL BO 0115 2,6-Dichlorphenylessigsure Guanfacine Impurity 1 2,6-DichlorophenylaceticAcid> Guanfacine Carboxylic Acid Impurity Guanfacine hydrochloride impurity B(2,6-Dichlorophenylacetic acid) Guanfacine Hydrochloride Impurity 3 2-(2,6-DICHLOROPHENYL)ACETIC ACID 6575-24-2 C8H6Cl2O2 C8H6O2Cl2 Carboxylic Acids Carbonyl Compounds C8 Building Blocks Organic Building Blocks C8 Carbonyl Compounds Carboxylic Acids Aromatic Phenylacetic Acids and Derivatives Phenylacetic acid Acids and Derivatives