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Oxaceprol

Oxaceprol structure

CAS No.: 33996-33-7

Chemical Name:: Oxaceprol

Synonyms: CO-61;AHP-200;Jonctum;Ac-L-Hyp;AC-HYP-OH;OXACEPROL;N-AC-L-HYP;Ac-L-Hyp-OH;trans-l-prolin;Hyp4001Ac-Hyp-Oh

CBNumber:: CB2482503

Molecular Formula:: C7H11NO4

Molecular Weight:: 173.17

MDL Number:: MFCD00037339

MOL File:: 33996-33-7.mol

MSDS File:: SDS

Last updated:2023-09-06 17:45:48

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Oxaceprol Properties

Melting point	132-133 °C (dec.)(lit.)
Boiling point	303.8°C (rough estimate)
alpha	-119 º (c=4 in H2O)
Density	1.3346 (rough estimate)
vapor pressure	0Pa at 20℃
refractive index	1.4490 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO : ≥ 32 mg/mL (184.79 mM)
pka	3.48±0.40(Predicted)
form	Crystalline Powder
color	White
optical activity	[α]20/D 119°, c = 4 in H2O
Merck	14,6903
BRN	84043
InChIKey	BAPRUDZDYCKSOQ-RITPCOANSA-N
LogP	-1.51 at 20℃
CAS DataBase Reference	33996-33-7(CAS DataBase Reference)
FDA UNII	Q0XV76B96L
ATC code	D11AX09,M01AX24
EPA Substance Registry System	L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

Safety Statements

26-36

WGK Germany

TSCA

Yes

HS Code

29339900

NFPA 704

	1
2		0

Oxaceprol price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	441562	trans-1-Acetyl-4-hydroxy-L-proline ≥98%	33996-33-7	10g	$170	2024-03-01	Buy
Alfa Aesar	B23767	N-Acetyl-trans-4-hydroxy-L-proline, 99%	33996-33-7	2g	$40.65	2024-03-01	Buy
Alfa Aesar	B23767	N-Acetyl-trans-4-hydroxy-L-proline, 99%	33996-33-7	10g	$136	2023-06-20	Buy
Alfa Aesar	B23767	N-Acetyl-trans-4-hydroxy-L-proline 99%	33996-33-7	5g	$79.2	2023-06-20	Buy
Alfa Aesar	B23767	N-Acetyl-trans-4-hydroxy-L-proline, 99%	33996-33-7	50g	$428	2021-12-16	Buy

Product number	Packaging	Price	Buy
441562	10g	$170	Buy
B23767	2g	$40.65	Buy
B23767	10g	$136	Buy
B23767	5g	$79.2	Buy
B23767	50g	$428	Buy

Oxaceprol Chemical Properties,Uses,Production

Chemical Properties

White powder

Originator

Jonctum,Merrell,France,1970

Uses

trans-1-Acetyl-4-hydroxy-L-proline can be used:

In the stereospecific synthesis of 4-fluoroglutamic acid.
To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).

Manufacturing Process

16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C.

Therapeutic Function

Antirheumatic

Flammability and Explosibility

Not classified

Oxaceprol synthesis

Synthesis of Oxaceprol from Acetic anhydride and L-Hydroxyproline

Oxaceprol Preparation Products And Raw materials

Raw materials

L-Hydroxyproline Acetic anhydride

Preparation Products

2-Oxa-5-azabicyclo[2.2.1]heptan-3-one, 5-acetyl-, (1R,4R)- (9CI)

Oxaceprol Suppliers

Global( 261)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58

Supplier	Advantage
DONBOO AMINO ACID COMPANY	58
Hebei Mojin Biotechnology Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from Oxaceprol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-12	Oxaceprol 33996-33-7	US $0.00-0.00 / KG	1KG	99%	10000 Mt/Year	Shaanxi Haibo Biotechnology Co., Ltd
2023-09-06	Oxaceprol 33996-33-7	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2021-09-29	N-Acetyl-L-hydroxyproline 33996-33-7	US $0.00 / Kg/Drum	1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD

Oxaceprol
33996-33-7
US $0.00-0.00 / KG
99%
Shaanxi Haibo Biotechnology Co., Ltd

Oxaceprol
33996-33-7
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

N-Acetyl-L-hydroxyproline
33996-33-7
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Oxaceprol Spectrum

Oxaceprol(33996-33-7)MS Oxaceprol(33996-33-7)IR1 Oxaceprol(33996-33-7)IR2

33996-33-7(Oxaceprol)Related Search:

Oxaceprol TRANS-1-BENZOYL-4-HYDROXY-L-PROLINE METHYL ESTER N-Tetradecanoyl-4-hydroxy-L-proline TRANS-1-BENZOYL-4-HYDROXY-L-PROLINE Dipalmitoyl hydroxyproline

N-Acetyl-L-Hydroxyproline L-Hydroxyproline L-Proline 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID H-GLY-ALA-HYP-OH

H-GLY-PRO-HYP-OH H-PRO-HYP-OH H-GLY-HYP-OH GLY-PRO-HYDROXY-PRO ACETATE SALT 1-(2-FURYLCARBONYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID

METHYL 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLATE Z-PRO-HYP-OH O-acetyl-L-hydroxyproline homopolymer,POLY-O-ACETYL-L-HYDROXYPROLINE)

1of4

TRANS-1-ACETYL-4-HYDROXY-L-PROLINE N-ACETYLHYDROXY-L-PROLINE N-ACETYL-L-HYDROXYPROLINE N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE N-ALPHA-ACETYL-L-HYROXYPROLINE (-)-1-Acetyl-4β-hydroxy-L-proline (4R)-1-Acetyl-4-hydroxy-L-proline trans-1-Acetyl-4-hydroxy-L-proline 99% trans-1-Acetyl-4-hydroxy-L-proline, >=98% Ac-Hyp-OH≥ 95% (TLC) Nα-Acetyl-L-4-trans-hydroxyproline trans-1-Acetyl-4-hydroxy-L-proline (4R,2S)-1-ACETYL-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID ACETYL-L-4-HYDROXYPROLINE ACETYL-4-HYDROXY-L-PROLINE AC-HYDROXYPROLINE AC-HYP-OH (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID OXACEPROL N-ACETYL-4-HYDROXY-L-PROLINE N-AC-L-HYP trans-l-prolin (R)-N-Acetyl-4-hydroxy-L-proline N-Acetyl-4-hydroxyproline N-Acetylhydroxyproline N-Acetyl-trans-4-hydroxy-L-proline AHP-200 CO-61 Jonctum N-Acetyl-L-hydroxyproline;trans-1-Acetyl-4-hydroxy-L-proline;1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid;AHP-200;CO-61;Jonctum;Oxaceprol 1-Acetyl-4-hydroxy-2-pyrrolidinecarboxylic acid Oxaceprol (trans-1-Acetyl-4-hydroxy-L-proline,monhydrate) Acetyl-trans-4-hydroxy-L-proline Hyp4001Ac-Hyp-Oh L-Proline, 1-acetyl-4-hydroxy-, (4R)- (9CI) (2S,4R)-N-ACETYL-4-HYDROXY-L-PROLINE N-Acetyl-L- 4-Hydroxyproline (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid Ac-L-Hyp-OH N-alpha-Acetyl-L-4-hydroxyproline Ac-L-Hyp N-Acetyl-L-Hydroproline L-Proline, 1-acetyl-4-hydroxy-, (4R)- Oxaceprol USP/EP/BP OxaceprolQ: What is Oxaceprol Q: What is the CAS Number of Oxaceprol Q: What is the storage condition of Oxaceprol Q: What are the applications of Oxaceprol 33996-33-7 33966-33-7 33996-33-8 C7H11NO4 Peptide Synthesis Proline Derivatives Specialty Synthesis Unnatural Amino Acid Derivatives Hydroxyproline [Hyp] PYRROLE API intermediates Amino Acids