2BAct(eIF2B activator 2BAct)
- CAS No.
- 2143542-28-1
- Chemical Name:
- 2BAct(eIF2B activator 2BAct)
- Synonyms
- 2BAct;2BAct, 10 mM in DMSO;2BAct(eIF2B activator 2BAct);N-(3-(2-(4-Chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-;permeable,primary,inhibit,Eukaryotic Initiation Factor (eIF),2BAct,stress,defects,response,fibroblast,neurological,Inhibitor,CNS
- CBNumber:
- CB24844420
- Molecular Formula:
- C19H16ClF3N4O3
- Molecular Weight:
- 440.8
- MDL Number:
- MFCD34567268
- MOL File:
- 2143542-28-1.mol
2BAct(eIF2B activator 2BAct) Chemical Properties,Uses,Production
Uses
2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1].
in vivo
2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice[1].
2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice[1].
2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response[1].
IC 50
eIF2
References
[1] Wong YL, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019;8:e42940. Published 2019 Jan 9. DOI:10.7554/eLife.42940
2BAct(eIF2B activator 2BAct) Preparation Products And Raw materials
Raw materials
Preparation Products
2BAct(eIF2B activator 2BAct) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
