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CB-6644

CB-6644 structure

CAS No.: 2316817-88-4

Chemical Name:: CB-6644

Synonyms: Chb-M';CB-6644;CB-6644 (CB6644;CB6644,CB-6644,Inhibitor,CB 6644,inhibit;Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-

CBNumber:: CB24844617

Molecular Formula:: C29H34ClFN4O5

Molecular Weight:: 573.06

MDL Number:: MFCD32689451

MOL File:: 2316817-88-4.mol

Last updated:2023-09-04 15:51:00

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CB-6644 Properties

Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:100.0(Max Conc. mg/mL);174.5(Max Conc. mM)
form	A solid
pka	13.13±0.20(Predicted)

CB-6644 Chemical Properties,Uses,Production

Biological Activity

CB-6644 is a selective RUVBL1/2 complex inhibitor. It inhibits the ATPase activity of RUVBL1/2 with IC50 of 15 nM; it also has anticancer activity.

in vitro

CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells.
CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI -1975, and HT29 cells) with an EC ₅₀ range of 41 to 785 nM.

Cell Viability Assay

Cell Line:	123 cell lines such as HCT116, NCI-1975, and HT29 cells
Concentration:	0.001, 0.01, 0.1, 1, and 10 μM
Incubation Time:	72 hours
Result:	Potently killed cells with an EC ₅₀ range of 41 to 785 nM.

in vivo

CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

Animal Model:	SCID-beige mice bearing human tumor xenografts derived from either Burkitt's lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines
Dosage: < /td>	150 mg/kg
Administration:	Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226
Result:	There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.

CB-6644 Preparation Products And Raw materials

Raw materials

Preparation Products

CB-6644 Suppliers

Global( 24)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238 17702719238	sales@sun-shinechem.com	China	905	64
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3421	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Wuhan Sun-shine Bio-technology Corporation Limited	+86-027-6552-2453	sales@sun-shinechem.com	China	727	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nextpeptide Inc	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	64
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
ShangHai Biochempartner Co.,Ltd	62
Wuhan Sun-shine Bio-technology Corporation Limited	58

CB-6644 Spectrum

CB-6644(2316817-88-4)¹HNMR

CB-6644 CB-6644 (CB6644 Chb-M' CB6644,CB-6644,Inhibitor,CB 6644,inhibit Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro- 2316817-88-4