ChemicalBook >> CAS DataBase List >>I-191 (I191)

I-191 (I191)

I-191 (I191) structure

CAS No.: 1690172-25-8

Chemical Name:: I-191 (I191)

Synonyms: I-191;I-191 (I191);I-191, 10 mM in DMSO;I-191,Inhibitor,I191,inhibit,I 191,Protease Activated Receptor (PAR),Thrombin receptors;4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one;4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one , I-191;2-Piperazinone, 4-[[8-(1,1-dimethylethyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]carbonyl]-3,3-dimethyl-

CBNumber:: CB24844884

Molecular Formula:: C23H26FN5O2

Molecular Weight:: 423.48

MDL Number:: MFCD32062778

MOL File:: 1690172-25-8.mol

Last updated:2025-04-28 21:36:36

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I-191 (I191) Properties

Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)\|
pka	13.69±0.40(Predicted)
form	Solid
color	White to gray
Water Solubility	Water : < 0.1 mg/mL (insoluble)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

I-191 (I191) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0068081	I-191 98.02%	1690172-25-8	5mg	$350	2021-12-16	Buy
ChemScene	CS-0068081	I-191 98.02%	1690172-25-8	10mg	$550	2021-12-16	Buy
Biorbyt Ltd	orb611302	I-191 >98%	1690172-25-8	100mg	$1133.9	2021-12-16	Buy
ChemScene	CS-0068081	I-191 98.02%	1690172-25-8	50mg	$1650	2021-12-16	Buy
Biorbyt Ltd	orb611302	I-191 >98%	1690172-25-8	250mg	$1802	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0068081	5mg	$350	Buy
CS-0068081	10mg	$550	Buy
orb611302	100mg	$1133.9	Buy
CS-0068081	50mg	$1650	Buy
orb611302	250mg	$1802	Buy

I-191 (I191) Chemical Properties,Uses,Production

Uses

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

IC 50

PAR2

References

[1] Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364(2):246-257. DOI:10.1124/jpet.117.245027

I-191 (I191) Preparation Products And Raw materials

Raw materials

Preparation Products

I-191 (I191) Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38664	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4611	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
LEAPCHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Shanghai Lollane Biological Technology Co.,Ltd.	55

View Lastest Price from I-191 (I191) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-28	I-191 1690172-25-8	US $82.00-198.00 / mg		99.80%	10g	TargetMol Chemicals Inc.

I-191
1690172-25-8
US $82.00-198.00 / mg
99.80%
TargetMol Chemicals Inc.

I-191 (I191) I-191 2-Piperazinone, 4-[[8-(1,1-dimethylethyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]carbonyl]-3,3-dimethyl- 4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one I-191,Inhibitor,I191,inhibit,I 191,Protease Activated Receptor (PAR),Thrombin receptors 4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one , I-191 I-191, 10 mM in DMSO 1690172-25-8