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P1

P1 Structure
P1 structure
CAS No.
1461648-55-4
Chemical Name:
P1
Synonyms
PDIINP1;PDI-IN-P1;PDI IN P1;PDI-inhibitor-P1;PDI inhibitor P1;PDI IN P1,PDI-IN-P-1;N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide;L-Tyrosinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-
CBNumber:
CB24866440
Molecular Formula:
C30H37N3O7S
Molecular Weight:
583.7
MDL Number:
MFCD30182261
MOL File:
1461648-55-4.mol
Last updated:2023-06-30 15:45:59
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P1 Properties

storage temp. Store at -20°C
solubility Soluble in DMSO

P1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P999045 P1 1461648-55-4 1mg $245 2021-12-16 Buy
Product number Packaging Price Buy
P999045 1mg $245 Buy

P1 Chemical Properties,Uses,Production

Uses

P1 is a starting material and useful building block of various pharmaceuticals.

Enzyme inhibitor

This cell-permeable PDI inhibitor (FW = 583.70 g/mol; CAS 1461648-55- 4; Soluble to 100 mM in DMSO; N-[(1,1-dimethylethoxy)carbonyl]-Lphenylalanyl-O-(ethenyl-sulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide) targets protein disulfide isomerase (IC50 = 1.7 μM), an enzyme that assists in the folding of cellular proteins within the endoplasmic reticulum of mammalian cells. P1 reduces the proliferation of numerous cancer cell lines, with nominal GI50 values of ～4 μM. PDI binds to the axonal microtubuleassociated protein known as Tau, mainly through its thioredoxin-like catalytic domain, by forming a one-to-one complex that prevents Tau misfolding.

storage

Store at -20°C

P1 Preparation Products And Raw materials

Raw materials

Preparation Products

P1 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32367 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
BOC Sciences -- info@bocsci.com USA 0 65
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5656 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 25433 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
Nantong QuanYi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide L-Tyrosinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl- PDI IN P1 PDI inhibitor P1 PDI-inhibitor-P1 PDIINP1 PDI-IN-P1 PDI IN P1,PDI-IN-P-1 1461648-55-4