Ethyl 4-aminocinnamate
- CAS No.
- 5048-82-8
- Chemical Name:
- Ethyl 4-aminocinnamate
- Synonyms
- Ethyl 4-aminocinnama;Ethyl 4-aminocinmate;4-AMINOETHYLCINNAMATE;ETHYL P-AMINOCINNAMATE;ETHYL 4-AMINOCINNAMATE;Ethyl 3-(4-aminophenyl);Ethyl4-aminocinnamate,97%;Ethyl 4-aminocinnamate 97%;Ethyl 3-(4-aMinophenyl)acrylate;4-AMINOCINNAMIC ACID ETHYL ESTER
- CBNumber:
- CB2486905
- Molecular Formula:
- C11H13NO2
- Molecular Weight:
- 191.23
- MDL Number:
- MFCD00017116
- MOL File:
- 5048-82-8.mol
- MSDS File:
- SDS
| Melting point | 70-74 °C (lit.) |
|---|---|
| Boiling point | 347.0±25.0 °C(Predicted) |
| Density | 1.130±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 2.89±0.10(Predicted) |
| form | solid |
| Appearance | Yellow to orange Solid |
| BRN | 2803541 |
| CAS DataBase Reference | 5048-82-8(CAS DataBase Reference) |
| FDA UNII | E61E38U5S1 |
| NIST Chemistry Reference | Ethyl p-aminocinnamate(5048-82-8) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(4-aminophenyl)-, ethyl ester (5048-82-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29163990 |
Ethyl 4-aminocinnamate price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E937873 | Ethyl 4-aminocinnamate | 5048-82-8 | 5g | $175 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0025373 | ETHYL 4-AMINOCINNAMATE 95.00% | 5048-82-8 | 1G | $648.81 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0025373 | ETHYL 4-AMINOCINNAMATE 95.00% | 5048-82-8 | 2.5G | $852.21 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0025373 | ETHYL 4-AMINOCINNAMATE 95.00% | 5048-82-8 | 5G | $1005.43 | 2021-12-16 | Buy |
| Crysdot | CD12067316 | Ethyl3-(4-aminophenyl)acrylate 97% | 5048-82-8 | 10g | $135 | 2021-12-16 | Buy |
Ethyl 4-aminocinnamate Chemical Properties,Uses,Production
Synthesis
24393-61-1
5048-82-8
General procedure for the synthesis of ethyl 4-aminocinnamate from ethyl (E)-3-(4-nitrophenyl)acrylate: to an 8 mL glass vial (14 mm diameter, 50 mm height) equipped with a PTFE-coated oval magnetic stirring bar (8.5 mm) and a plastic screw cap was added ethyl (E)-3-(4-nitrophenyl)acrylate (0.5 mmol, 1.0 equivalents), Fe2O3/NGr(at)C catalyst (50 mg, 4.0 mol% Fe), triethylamine (Et3N, 70 μL, 0.5 mmol, 1.0 equivalents), tetrahydrofuran (THF, 2 mL) and deionized water (H2O, 0.2 mL). The silicone septum was punctured with a 26-gauge syringe needle (0.45 × 12 mm), and the vial was placed in an aluminum plate and transferred to a 300-mL autoclave. After sealing the autoclave, it was placed in an aluminum block and purged with carbon monoxide (CO, 5-10 bar) three times. This was followed by pressurization with CO to 30 bar and addition of nitrogen (N2) at 20 bar. The aluminum block was heated to 125°C with sufficient stirring (700 rpm). After 24 hours of reaction, the autoclave was removed from the aluminum block and cooled to room temperature. After releasing the remaining gas in a water bath, the vial containing the reaction mixture was removed. The reaction mixture was filtered through a diatomaceous earth pad (about 1 cm thick), the filtrate was concentrated and finally analyzed by gas chromatography (GC) and nuclear magnetic resonance (NMR) spectroscopy (Table 2).
References
[1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 2-3, p. 321 - 327
[2] Synthesis (Germany), 2018, vol. 50, # 22, p. 4369 - 4376
[3] Journal of Organic Chemistry, 1999, vol. 64, # 7, p. 2301 - 2303
[4] Organic Letters, 2017, vol. 19, # 24, p. 6518 - 6521
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
Ethyl 4-aminocinnamate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7921 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Changzhou Fullone Chemical Co., Ltd. | +86-13328197671 +86-13861172460 | sales@borenchem.cn | China | 1055 | 58 |
View Lastest Price from Ethyl 4-aminocinnamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-24 | Ethyl 4-aminocinnamate
5048-82-8
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2023-12-24 | Ethyl 4-aminocinnamate
5048-82-8
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2019-07-06 | Ethyl 4-aminocinnamate
5048-82-8
|
US $8.00 / kg | 1kg | 99% | 10MT | Career Henan Chemical Co |
-
- Ethyl 4-aminocinnamate
5048-82-8
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl 4-aminocinnamate
5048-82-8
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Ethyl 4-aminocinnamate
5048-82-8
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
