Acipimox

Acipimox price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A7856	Acipimox ≥99% (TLC)	51037-30-0	1g	$89.8	2020-08-18	Buy
TCI Chemical	M2053	5-Methylpyrazine-2-carboxylic Acid 4-Oxide >98.0%(GC)	51037-30-0	1g	$84	2020-06-24	Buy
TCI Chemical	M2053	5-Methylpyrazine-2-carboxylic Acid 4-Oxide >98.0%(GC)	51037-30-0	5g	$251	2020-06-24	Buy
Cayman Chemical	26090	Acipimox ≥95%	51037-30-0	500mg	$35	2020-06-24	Buy
Cayman Chemical	26090	Acipimox ≥95%	51037-30-0	1g	$60	2020-06-24	Buy

Acipimox Chemical Properties,Uses,Production

Description

Acipimox is a potent long-acting antilipolytic nicotinic acid (NA) analog. Like nicotinic acid, acipimox lowers lipids effectively, but unlike nicotinic acid, acipimox is longer acting and therefore much less prone to produce free fatty acid rebounding.
Acipimox is recommended as a lipid-lowering agent to treat hyperlipidemia in patients with noninsulin dependent diabetes mellitus.

References

[1] Ana T.M.G. Santomauro, Guenther Boden, Maria E.R. Silva, Dalva M. Rocha, Rosa F. Santos, Mileni J.M. Ursich, Paula G. Strassmann and Bernardo L. Wajchenberg, Overnight Lowering of Free Fatty Acids With Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects, Diabetes, 1999, vol. 48, 1836-1841
[2] K. C. Shih, C. F. Kwok, C. M. Hwu, L. C. Hsiao, S. H. Li, Y. F. Liu, L. T. Ho, Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control, Diabetes Research and Clinical Practice, 1997, vol. 36, 113-119

Description

Acipimox is a hypolipidemic agent related to nicotinic acid with pronounced, longlasting antilipolytic activity. In addition to its lipid lowering activity, it produces a beneficial elevation of the anti-atherogenic high density lipoprotein subfraction, HDL2.

Chemical Properties

Yellow Solid

Originator

Erbamont (Italy)

Uses

Antilipemic.

Manufacturing Process

2-Carboxy-5-methylpyazine (9.7 g) in dry dioxan (114 ml) and tributylamine (17.7 ml) was treated with ethyl chloroformate (7.5 ml), keeping the temperature at 0-5°C. After 10 min, dioxan (190 ml) saturated with ammonia was added. The mixture was stirred for 3 h at room temperature, then dioxin was distilled off, and the residue was taken up tin saturated aqueous sodium bicarbonate (20 ml). The mixture was filtered and the product washed with water to give 2-carbamoyl-5-methylpyrazine (9.2 g), melting point 204°- 206°C.
This 2-carbamoyl-5-methylpyrazine (7.0 g) in glacial acetic acid (30 ml) and 35% (w/v) hydrogen peroxide (20 ml) was heated with stirring at 70°C for 7 h. The reaction mixture was cooled, the product which separated was filtered and washed with water to give 2-carbamoyl-5-methylpyrazine-4-oxide (5.5 g), melting point 206°-208°C.
2-Carbamoyl-5-methylpyrazine 4-oxide (5.0 g) was added to 10% by weight sodium hydroxide (50 ml) and then refluxed for 30 min. The reaction mixture was acidified with dilute hydrochloric acid and extracted in a continuous extractor with ethyl acetate. The ethyl acetate extract was concentrated to small volume and gave, after filtration 2-carboxy-5-methylpyrazine 4-oxide (3.2 g), melting point 178°-180°C.

brand name

OLBETAM

Therapeutic Function

Antihyperlipidemic

Biological Activity

Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.

Acipimox Preparation Products And Raw materials

Raw materials

Preparation Products

Acipimox Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872		christine@shengqipharm.com	CHINA	478	58
Henan DaKen Chemical CO.,LTD.	+86-371-55531817		info@dakenchem.com	CHINA	21717	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	0371-55170693	info@tianfuchem.com	CHINA	22622	55
Xiamen AmoyChem Co., Ltd	+86 592-605 1114		sales@amoychem.com	CHINA	6371	58
Alchem Pharmtech,Inc.	8485655694		sales@alchempharmtech.com	United States	63728	58
CONIER CHEM AND PHARMA LIMITED	86-18523575427		sales@conier.com	CHINA	47486	58
career henan chemical co	13203830695 0086-371-86658258	0086-371-86658258	factory@coreychem.com	CHINA	29873	58
Shaanxi Dideu Medichem Co. Ltd	+86-15319487004	+86-29-88380327	1015@dideu.com	CHINA	3927	58
Target Molecule Corp	18019718960 781-999-5354		marketing@targetmol.com	United States	19233	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	0551-65418697	sales@tnjchem.com	CHINA	37442	58

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