ChemicalBook
Chinese Japanese Germany Korea

Acipimox

Description References
Acipimox
Acipimox structure
CAS No.
51037-30-0
Chemical Name:
Acipimox
Synonyms
K-9321;Olbetam;Olbemox;ACIPIMOX;AcipiMox-13C2,15N2;Methylpyrazine Oxide;Acipimox Solution, 100ppm;Acipimox Solution, 1000ppm;5-Carboxy-2-methylpyrazine 1-oxide;2-Carboxy-5-methylpyrazine 4-oxide
CBNumber:
CB2490951
Molecular Formula:
C6H6N2O3
Formula Weight:
154.12
MOL File:
51037-30-0.mol

Acipimox Properties

Melting point:
177-180 °C
Boiling point:
539.0±45.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.80±0.10(Predicted)
Merck 
14,111
InChIKey
DJQOOSBJCLSSEY-UHFFFAOYSA-N
CAS DataBase Reference
51037-30-0(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
K9AY9IR2SD
EPA Substance Registry System
Pyrazinecarboxylic acid, 5-methyl-, 4-oxide (51037-30-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
RTECS  UQ2453000
Toxicity LD50 orally in mice: 3500 mg/kg (Ambrogi)

Acipimox price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A7856 Acipimox ≥99% (TLC) 51037-30-0 1g $89.8 2020-08-18 Buy
TCI Chemical M2053 5-Methylpyrazine-2-carboxylic Acid 4-Oxide >98.0%(GC) 51037-30-0 1g $84 2020-06-24 Buy
TCI Chemical M2053 5-Methylpyrazine-2-carboxylic Acid 4-Oxide >98.0%(GC) 51037-30-0 5g $251 2020-06-24 Buy
Cayman Chemical 26090 Acipimox ≥95% 51037-30-0 500mg $35 2020-06-24 Buy
Cayman Chemical 26090 Acipimox ≥95% 51037-30-0 1g $60 2020-06-24 Buy

Acipimox Chemical Properties,Uses,Production

Description

Acipimox is a potent long-acting antilipolytic nicotinic acid (NA) analog. Like nicotinic acid, acipimox lowers lipids effectively, but unlike nicotinic acid, acipimox is longer acting and therefore much less prone to produce free fatty acid rebounding.
Acipimox is recommended as a lipid-lowering agent to treat hyperlipidemia in patients with noninsulin dependent diabetes mellitus.

References

[1] Ana T.M.G. Santomauro, Guenther Boden, Maria E.R. Silva, Dalva M. Rocha, Rosa F. Santos, Mileni J.M. Ursich, Paula G. Strassmann and Bernardo L. Wajchenberg, Overnight Lowering of Free Fatty Acids With Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects, Diabetes, 1999, vol. 48, 1836-1841
[2] K. C. Shih, C. F. Kwok, C. M. Hwu, L. C. Hsiao, S. H. Li, Y. F. Liu, L. T. Ho, Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control, Diabetes Research and Clinical Practice, 1997, vol. 36, 113-119

Description

Acipimox is a hypolipidemic agent related to nicotinic acid with pronounced, longlasting antilipolytic activity. In addition to its lipid lowering activity, it produces a beneficial elevation of the anti-atherogenic high density lipoprotein subfraction, HDL2.

Chemical Properties

Yellow Solid

Originator

Erbamont (Italy)

Uses

Antilipemic.

Manufacturing Process

2-Carboxy-5-methylpyazine (9.7 g) in dry dioxan (114 ml) and tributylamine (17.7 ml) was treated with ethyl chloroformate (7.5 ml), keeping the temperature at 0-5°C. After 10 min, dioxan (190 ml) saturated with ammonia was added. The mixture was stirred for 3 h at room temperature, then dioxin was distilled off, and the residue was taken up tin saturated aqueous sodium bicarbonate (20 ml). The mixture was filtered and the product washed with water to give 2-carbamoyl-5-methylpyrazine (9.2 g), melting point 204°- 206°C.
This 2-carbamoyl-5-methylpyrazine (7.0 g) in glacial acetic acid (30 ml) and 35% (w/v) hydrogen peroxide (20 ml) was heated with stirring at 70°C for 7 h. The reaction mixture was cooled, the product which separated was filtered and washed with water to give 2-carbamoyl-5-methylpyrazine-4-oxide (5.5 g), melting point 206°-208°C.
2-Carbamoyl-5-methylpyrazine 4-oxide (5.0 g) was added to 10% by weight sodium hydroxide (50 ml) and then refluxed for 30 min. The reaction mixture was acidified with dilute hydrochloric acid and extracted in a continuous extractor with ethyl acetate. The ethyl acetate extract was concentrated to small volume and gave, after filtration 2-carboxy-5-methylpyrazine 4-oxide (3.2 g), melting point 178°-180°C.

brand name

OLBETAM

Therapeutic Function

Antihyperlipidemic

Biological Activity

Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.

Acipimox Preparation Products And Raw materials

Raw materials

Preparation Products


Acipimox Suppliers

Global( 207)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 478 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21717 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22622 55
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63728 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29873 58
Shaanxi Dideu Medichem Co. Ltd
+86-15319487004
+86-29-88380327 1015@dideu.com CHINA 3927 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19233 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37442 58

View Lastest Price from Acipimox manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-06 Acipimox
51037-30-0
US $0.00 / kg 1kg 98 10MT Jinan Shengqi pharmaceutical Co,Ltd
2020-05-11 Acipimox
51037-30-0
US $0.00-0.00 / KG 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
2020-02-17 Acipimox
51037-30-0
US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

51037-30-0(Acipimox)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved