3-(METHYLSULFONYL)ANILINE
- CAS No.
- 35216-39-8
- Chemical Name:
- 3-(METHYLSULFONYL)ANILINE
- Synonyms
- m-(Methylsulfonyl)aniline;3-(Methylsulphonyl)aniline;3-Methylsulfonylphenylamine;P-Toluene Suphonamide (PTSA);3-Aminophenyl methyl sulfone;3-(methylsulfonyl)Benzenamine;3-Aminophenyl methyl sulphone;Benzenamine, 3-(methylsulfonyl)-
- CBNumber:
- CB2500645
- Molecular Formula:
- C7H9NO2S
- Molecular Weight:
- 171.22
- MDL Number:
- MFCD03764428
- MOL File:
- 35216-39-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-(Methanesulfonyl)aniline | M218785 | 50mg | $45 |
| 3-(Methanesulfonyl)aniline | M218785 | 100mg | $60 |
| 3-(Methylsulphonyl)aniline >95% | 127742 | 500mg | $134 |
| 3-(Methylsulfonyl)aniline | 8663-1-Z6 | 1g | $45 |
| 3-(Methylsulfonyl)aniline | Y5090 | 25g | $727 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2921420090 |
3-(METHYLSULFONYL)ANILINE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M218785 | 3-(Methanesulfonyl)aniline | 35216-39-8 | 50mg | $45 | 2021-12-16 | Buy |
| TRC | M218785 | 3-(Methanesulfonyl)aniline | 35216-39-8 | 100mg | $60 | 2021-12-16 | Buy |
| Matrix Scientific | 127742 | 3-(Methylsulphonyl)aniline >95% | 35216-39-8 | 500mg | $134 | 2021-12-16 | Buy |
| SynQuest Laboratories | 8663-1-Z6 | 3-(Methylsulfonyl)aniline | 35216-39-8 | 1g | $45 | 2021-12-16 | Buy |
| AK Scientific | Y5090 | 3-(Methylsulfonyl)aniline | 35216-39-8 | 25g | $727 | 2021-12-16 | Buy |
3-(METHYLSULFONYL)ANILINE Chemical Properties,Uses,Production
Uses
3-(Methylsulfonyl)aniline is used in the preparation of substituted pyrazolopyrimidines as IRAK4 kinase inhibitors.
Synthesis
1783-81-9
35216-39-8
General procedure for the synthesis of 3-methylsulfonylaniline from 3-aminothioanisole: A mixture of Na2WO4 (0.067 g), 1 drop of acetic acid and H2O (5 mL) was added to a flask and heated to 65 °C. Subsequently, 3-methylthioaniline (500 mg, 3.59 mmol) was added and H2O2 (1.1 mL, 10.77 mmol) was added slowly and dropwise. The reaction mixture was stirred at 65 °C for 1.5 hours. After completion of the reaction, it was cooled to room temperature and extracted by adding 1N HCl (80 mL) and DCM (50 mL). The organic and aqueous phases were separated and the aqueous phase was then washed with DCM. The aqueous phase was alkalized with 25% NaOH solution and extracted with DCM. The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to give the 3-methylsulfonylaniline derivative.Preparation of 3-(methylsulfonyl)aniline (158): Compound 158 was prepared from 3-methylsulfonylaniline (153) according to Method E. 557 mg of brown powder was obtained in 92% yield.1H NMR (500 MHz, CDCl3) δ 3.03 (s, 3H), 6.89 (ddd, J = 0.8, 2.3, 8.0 Hz, 1H), 7.21 (t, J = 2.1 Hz, 1H), 7.24 (dt, J = 1.1, 7.7 Hz, 1H), 7.30 (t, J = 7.8 Hz, 1H). 13C NMR (126 MHz, CDCl3) δ 44.40, 112.69, 116.37, 119.72, 130.30, 141.16, 141.16. 130.30, 141.16, 147.69. LC-MS (M+H+) calculated value C7H9NO2S 172, measured value 172.
References
[1] Patent: WO2014/100833, 2014, A1. Location in patent: Paragraph 0080; 0232
[2] Patent: WO2007/60026, 2007, A1. Location in patent: Page/Page column 49-50
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 18, p. 4741 - 4745
3-(METHYLSULFONYL)ANILINE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3999 | 58 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15126 | 58 |
View Lastest Price from 3-(METHYLSULFONYL)ANILINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-17 | 3-(METHYLSULFONYL)ANILINE
35216-39-8
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | 3-(METHYLSULFONYL)ANILINE
35216-39-8
|
US $0.01 / KG | 1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
-
- 3-(METHYLSULFONYL)ANILINE
35216-39-8
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-(METHYLSULFONYL)ANILINE
35216-39-8
- US $0.01 / KG
- 98%; 99%
- Career Henan Chemical Co
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