Methenamine hippurate
- CAS No.
- 5714-73-8
- Chemical Name:
- Methenamine hippurate
- Synonyms
- r-657;D00855;hiprex;haiprex;Urex (tn);cane(1:1);hippramine;Hiprex (tn);Methenamine hippurate;METHENAMINEHIPPURATE,USP
- CBNumber:
- CB2501374
- Molecular Formula:
- C15H21N5O3
- Molecular Weight:
- 319.37
- MDL Number:
- MFCD00072147
- MOL File:
- 5714-73-8.mol
- MSDS File:
- SDS
| Melting point | 89-95°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | M329791L57 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P321-P332+P313-P337+P313-P362 | |||||||||
| HS Code | 2933690000 | |||||||||
| NFPA 704 |
|
Methenamine hippurate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24004 | Methenamine Hippurate ≥98% | 5714-73-8 | 100mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 24004 | Methenamine Hippurate ≥98% | 5714-73-8 | 250mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 24004 | Methenamine Hippurate ≥98% | 5714-73-8 | 500mg | $220 | 2024-03-01 | Buy |
| TRC | M226025 | MethenamineHippurate | 5714-73-8 | 1g | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0013675 | Methenamine(hippurate) | 5714-73-8 | 250mg | $120 | 2021-12-16 | Buy |
Methenamine hippurate Chemical Properties,Uses,Production
Description
Methenamine hippurate is a broad-spectrum urinary antiseptic agent. Under acidic conditions, methenamine hippurate is hydrolyzed to formaldehyde and ammonia, which exerts an antibacterial effect. It is effective against a wide range of bacteria but lacks activity against Proteus and other bacteria that increase urine alkalinity. Formulations containing methenamine hippurate have been used to treat urinary tract infections.
Chemical Properties
White Solid
Originator
Hiprex ,Merrell National,US,1967
Uses
Antibacterial (urinary).
Definition
ChEBI: Methenamine hippurate is a N-acylglycine. It is functionally related to a N-benzoylglycine.
Manufacturing Process
179 g (1 mol) hippuric acid (benzoyl glycine) and 140 g (1 mol) hexamethylenetetramine were heated under reflux in 500 ml methanol. The small amount of water necessary to give a clear, homogeneous solution was added to the resulting reaction mixture which was then evaporated to dryness. The residue soon crystallized, a procedure that could be greatly accelerated by seeding with crystals of hexamethylenetetramine hippurate from a previous preparation. The resulting solid product was broken up and pulverized. Hexamethylenetetramine hippurate is stable on exposure to air and is soluble in water and alcohol. It melts at 105° to 110°C.
brand name
Urex(Vatring).
Therapeutic Function
Antibacterial (urinary)
General Description
Methenamine hippurate (Hiprex) is the hippuric acid salt ofmethenamine. It is readily absorbed after oral administrationand is concentrated in the urinary bladder, where it exerts itsantibacterial activity. Its activity is increased in acid urine.
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: increased risk of crystalluria with
sulphonamides.
Diuretics: effects antagonised by acetazolamide.
Metabolism
Under acid conditions methenamine is slowly hydrolysed to formaldehyde and ammonia. Almost no hydrolysis of methenamine takes place at physiological pH, and it is therefore virtually inactive in the body. Methenamine is rapidly and almost completely eliminated in the urine, and provided this is acidic (preferably below pH 5.5) bactericidal concentrations of formaldehyde occur. Because of the time taken for hydrolysis, however, these do not occur until the urine reaches the bladder.
Methenamine hippurate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Methenamine hippurate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-23 | Methenamine hippurate USP/EP/BP
5714-73-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-04 | Methenamine hippurate
5714-73-8
|
US $0.00-0.00 / KG | 1KG | 99.0% | 600 Tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Methenamine hippurate USP/EP/BP
5714-73-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Methenamine hippurate
5714-73-8
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd