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Entinostat

CAS No.
209783-80-2
Chemical Name:
Entinostat
Synonyms
Rivipansel;CS-189;MS 2275;Entenot;Nsc706995;MS 275-27;entinostat;MS275;MS 275;MS275; SNDX 275;Entinostat/MS-275
CBNumber:
CB2503893
Molecular Formula:
C21H20N4O3
Molecular Weight:
376.41
MDL Number:
MFCD08272435
MOL File:
209783-80-2.mol
Last updated:2023-08-29 17:14:30

Entinostat Properties

Melting point 159-160 ºC
Boiling point 566.7±50.0 °C(Predicted)
Density 1.315
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO: 38 mg/mL, soluble
form solid
pka 11.32±0.46(Predicted)
color Pale yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey INVTYAOGFAGBOE-UHFFFAOYSA-N
NCI Dictionary of Cancer Terms entinostat
FDA UNII 1ZNY4FKK9H
NCI Drug Dictionary entinostat
ATC code L01XH05

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H360
Precautionary statements  P201-P301+P310+P330
Hazard Codes  Xi,T
Risk Statements  36/37/38-62-48/25-25-61
Safety Statements  26-36-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  29333990
NFPA 704
0
2 0

Entinostat price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich EPS002 MS-275 A HDAC1 and HDAC3 inhibitor 209783-80-2 1mg $399 2023-06-20 Buy
Sigma-Aldrich EPS002 MS-275 A HDAC1 and HDAC3 inhibitor 209783-80-2 5mg $1190 2023-06-20 Buy
Cayman Chemical 13284 MS-275 ≥98% 209783-80-2 1mg $21 2024-03-01 Buy
Cayman Chemical 13284 MS-275 ≥98% 209783-80-2 5mg $61 2024-03-01 Buy
Cayman Chemical 13284 MS-275 ≥98% 209783-80-2 10mg $109 2024-03-01 Buy
Product number Packaging Price Buy
EPS002 1mg $399 Buy
EPS002 5mg $1190 Buy
13284 1mg $21 Buy
13284 5mg $61 Buy
13284 10mg $109 Buy

Entinostat Chemical Properties,Uses,Production

Description

Entinostat (SNDX-275, MS-275) belongs to benzamide class HDACi and inhibits HDAC1 and 2, 3 and 9 and has low effect against HDAC4, 6, 7 and 8 (Khan et al. 2007). Entinostat is in phase II clinical trial for treatment of Hodgkin's lymphoma and advanced breast cancer (in combination with aromatase inhibitors) and metastatic lung cancer (in combination with erlotinib).

Chemical Properties

Yellow Solid

Uses

Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies. Potent Histone deacetylase inhibitor.

Definition

ChEBI: A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibit r of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3).

Clinical Use

Entinostat is an HDAC inhibitor with a relatively long half-life (averaging between 33 and 52 hours). Trials have shown significant biological activity in patients with hematological malignancies receiving entinostat treatments. However, the efficacy of entinostat as a single-agent therapy remains limited. Reported dose-limiting toxicities associated with entinostat include neurotoxicity, fatigue, hypophosphatemia, anorexia, and vomiting.
The large number of clinical trials using HDAC inhibitors for the treatment of patients with hematological malignancies has demonstrated that these drugs are relatively well tolerated. Although the responses with the currently-available HDAC inhibitors are still limited, there are significant responses in some patients with advanced disease, where options are limited. With better patient selection and the development of more potent HDAC inhibitors, targeting HDACs for the treatment of hematological malignancies remains promising. Furthermore, a growing body of literature suggests that HDAC inhibitors may potentiate some of the currently used cytotoxic or biologic therapies based on their mechanism of action, with multiple trials currently ongoing. Promising combination partners include proteosome inhibitors, DNA demethylating agents, and anthracyclines.

target

HDAC1

storage

+4°C

References

1) Hu et al. (2003), Identification of novel isoform-selective inhibitors within class 1 histone deacetylases; J. Pharmacol. Exp. Ther., 307 720 2) Saito et al. (1999), A synthetic inhibitor of histone deacetylase, MS-275, with marked in vivo antitumor activity against human tumors; Proc. Natl. Acad. Sci. USA, 96 4592 3) Eyupoglu et al. (2006), Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275; Mol. Cancer Ther., 5 1248 4) Lee et al. (2001), MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells; J. Pharmacol. Exp. Ther., 307 720 5) Lin et al. (2007), Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents; Br. J. Pharmacol., 150 862 6) Fukuchi et al. (2015), Class I histone deacetylase-mediated repression of the proximal promoter of the Activity-regulated Cytoskeleton-associated Protein Gene regulates its response to brain-derived neurotrophic factor; J. Biol. Chem. 290 6825 [Focus Biomolecules Citation]

Entinostat Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 222)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58

View Lastest Price from Entinostat manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Entinostat pictures 2023-11-08 Entinostat
209783-80-2
US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
MS-275 (Entinostat) pictures 2021-10-08 MS-275 (Entinostat)
209783-80-2
US $0.00-0.00 / g 1g 98%+ 100kgs Wuhan Nutra Biotechnology Co.,Ltd
Entinostat pictures 2019-07-06 Entinostat
209783-80-2
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Entinostat pictures
  • Entinostat
    209783-80-2
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
  • Entinostat pictures
  • Entinostat
    209783-80-2
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

Entinostat Spectrum

Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester entinostat 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester Entinostat/MS-275 Nsc706995 Entinostat(NSC-706995) (Pyridin-3-yl)Methyl 4-(2-AMinophenylcarbaMoyl)benzylcarbaMate MS 275-27 MS-275,Entinostat,SNDX-275 MS-275 (Entinostat) Entinostat (MS-275,SNDX-275) [4-(2-Amino-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester Entinostat N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester Entinostat (MS-275, SNDX-275) entinostat(HDAC inhibitor) Entinostat, >=98% Entinostat (MS-27-275) entinostat side effects MS 2275 Entinostat USP/EP/BP MS275; SNDX 275 CS-189 MS275;MS 275 Rivipansel Entenot 209783-80-2 Inhibitors API Inhibitor SNDX 275 Entinostat