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Entinostat

Entinostat
Entinostat structure
CAS No.
209783-80-2
Chemical Name:
Entinostat
Synonyms
MS 275-27;Nsc706995;entinostat;Rivipansel;Entinostat/MS-275;Entinostat, >=98%;MS-275 (Entinostat);Entinostat(NSC-706995);MS-275,Entinostat,SNDX-275;entinostat(HDAC inhibitor)
CBNumber:
CB2503893
Molecular Formula:
C21H20N4O3
Formula Weight:
376.4085
MOL File:
209783-80-2.mol

Entinostat Properties

Melting point:
159-160 ºC
Density 
1.315
storage temp. 
−20°C
solubility 
DMSO: 38 mg/mL, soluble
form 
solid
InChIKey
INVTYAOGFAGBOE-UHFFFAOYSA-N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H315-H319-H335-H360
Precautionary statements  P201-P261-P301+P310-P305+P351+P338-P308+P313
Hazard Codes  Xi,T
Risk Statements  36/37/38-62-48/25-25-61
Safety Statements  26-36-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  29333990

Entinostat price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich EPS002 MS-275 A HDAC1 and HDAC3 inhibitor 209783-80-2 1mg $315 2018-11-20 Buy
Sigma-Aldrich EPS002 MS-275 A HDAC1 and HDAC3 inhibitor 209783-80-2 5mg $938 2018-11-20 Buy
Cayman Chemical 13284 MS-275 ≥98% 209783-80-2 1mg $16 2018-11-13 Buy
Cayman Chemical 13284 MS-275 ≥98% 209783-80-2 5mg $64 2018-11-13 Buy
Cayman Chemical 13284 MS-275 ≥98% 209783-80-2 10mg $96 2018-11-13 Buy

Entinostat Chemical Properties,Uses,Production

Description

Entinostat (SNDX-275, MS-275) belongs to benzamide class HDACi and inhibits HDAC1 and 2, 3 and 9 and has low effect against HDAC4, 6, 7 and 8 (Khan et al. 2007). Entinostat is in phase II clinical trial for treatment of Hodgkin's lymphoma and advanced breast cancer (in combination with aromatase inhibitors) and metastatic lung cancer (in combination with erlotinib).

Chemical Properties

Yellow Solid

Uses

Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies.

Definition

ChEBI: A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibit r of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3).

Clinical Use

Entinostat is an HDAC inhibitor with a relatively long half-life (averaging between 33 and 52 hours). Trials have shown significant biological activity in patients with hematological malignancies receiving entinostat treatments. However, the efficacy of entinostat as a single-agent therapy remains limited. Reported dose-limiting toxicities associated with entinostat include neurotoxicity, fatigue, hypophosphatemia, anorexia, and vomiting.
The large number of clinical trials using HDAC inhibitors for the treatment of patients with hematological malignancies has demonstrated that these drugs are relatively well tolerated. Although the responses with the currently-available HDAC inhibitors are still limited, there are significant responses in some patients with advanced disease, where options are limited. With better patient selection and the development of more potent HDAC inhibitors, targeting HDACs for the treatment of hematological malignancies remains promising. Furthermore, a growing body of literature suggests that HDAC inhibitors may potentiate some of the currently used cytotoxic or biologic therapies based on their mechanism of action, with multiple trials currently ongoing. Promising combination partners include proteosome inhibitors, DNA demethylating agents, and anthracyclines.

Entinostat Preparation Products And Raw materials

Raw materials

Preparation Products


Entinostat Suppliers

Global( 126)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63729 58
AdooQ Bioscience CHINA 025-58849295
025-68650336 info@adooq.cn China 3018 60

View Lastest Price from Entinostat manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Entinostat
209783-80-2
US $2.00 / kg 1kg 99% 100kg career henan chemical co

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