MD2-TLR4-IN-1
- CAS No.
- 2249801-12-3
- Chemical Name:
- MD2-TLR4-IN-1
- Synonyms
- MD2-TLR4-I;MD2-TLR4-IN-1;MD2-TLR4-IN-1, 10 mM in DMSO;N-(3-(1H-Indol-5-yl)-1H-indazol-5-yl)-2,6-dichlorobenzamide;Benzamide, 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]-;inhibit,Toll-like Receptor (TLR),MD2 TLR4 IN 1,MD2TLR4IN1,MD-2-TLR4-IN-1,Inhibitor
- CBNumber:
- CB25478163
- Molecular Formula:
- C22H14Cl2N4O
- Molecular Weight:
- 421.28
- MDL Number:
- MFCD32067977
- MOL File:
- 2249801-12-3.mol
| Product description | Number | Pack Size | Price |
| MD2-TLR4-IN-1 99.69% | CS-0096014 | 5mg | $350 |
| MD2-TLR4-IN-1 99.69% | CS-0096014 | 10mg | $550 |
| MD2-TLR4-IN-1 99.69% | CS-0096014 | 25mg | $990 |
| MD2-TLR4-IN-1 99.69% | CS-0096014 | 50mg | $1650 |
| MD2-TLR4-IN-1 99.69% | CS-0096014 | 100mg | $2250 |
MD2-TLR4-IN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0096014 | MD2-TLR4-IN-1 99.69% | 2249801-12-3 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0096014 | MD2-TLR4-IN-1 99.69% | 2249801-12-3 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0096014 | MD2-TLR4-IN-1 99.69% | 2249801-12-3 | 25mg | $990 | 2021-12-16 | Buy |
| ChemScene | CS-0096014 | MD2-TLR4-IN-1 99.69% | 2249801-12-3 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0096014 | MD2-TLR4-IN-1 99.69% | 2249801-12-3 | 100mg | $2250 | 2021-12-16 | Buy |
MD2-TLR4-IN-1 Chemical Properties,Uses,Production
Uses
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].
References
[1] Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469. DOI:10.1021/acs.jmedchem.9b00316
MD2-TLR4-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MD2-TLR4-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2391 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4984 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9125 | 58 |
