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AZD9898

AZD9898 structure

CAS No.: 2042347-69-1

Chemical Name:: AZD9898

Synonyms: AZD9898;AZD-9898,AZD9898;Cyclopropanecarboxylic acid, 2-[[5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxy-2-pyrazinyl]carbonyl]-, (1S,2S)-

CBNumber:: CB25821448

Molecular Formula:: C20H19ClF3N3O4

Molecular Weight:: 457.83

MDL Number:: MFCD32201104

MOL File:: 2042347-69-1.mol

Last updated:2023-02-23 14:24:04

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AZD9898 Properties

Boiling point	633.8±55.0 °C(Predicted)
Density	1.463±0.06 g/cm3(Predicted)
pka	3.58±0.11(Predicted)

AZD9898 Chemical Properties,Uses,Production

Biological Activity

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1]. AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1].

References

[1]. Munck Af Rosensch?ld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J Med Chem. 2019 Aug 30.

AZD9898 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD9898 Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3421	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Chunchuang (Wuhan) Technology Co., Ltd	15342225168	yutianchun2007@126.com	China	9964	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4030	58
Jinan Sanbao Biotechnology Co., Ltd.	13854185395; 13854185395	sanbaobiotech@126.com	China	8453	58
RD International Technology Co., Limited	18988968278	sales@ubiochem.com	China	9146	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
DC Chemicals	58
Chunchuang (Wuhan) Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Jinan Sanbao Biotechnology Co., Ltd.	58
RD International Technology Co., Limited	58

AZD9898 Cyclopropanecarboxylic acid, 2-[[5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxy-2-pyrazinyl]carbonyl]-, (1S,2S)- AZD-9898,AZD9898 2042347-69-1 C20H19ClF3N3O4