4-Chloro-3,5-dimethylphenol

4-Chloro-3,5-dimethylphenol Properties

Melting point	114-116 °C(lit.)
Boiling point	246 °C
Density	0.67 g/cm3
refractive index	1.5523 (estimate)
Flash point	132 °C
storage temp.	2-8°C
solubility	methanol: soluble1g/10 mL, clear to faintly turbid, colorless to very faintly yellow
pka	9.76±0.23(Predicted)
form	Crystalline Powder or Crystals
color	White to light beige
PH	7 (0.2g/l, H2O)
Odor	wh. cryst. or cryst. powd., char. phenolic odor
Water Solubility	0.3 g/L (20 ºC)
Merck	14,2176
BRN	1862539
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	OSDLLIBGSJNGJE-UHFFFAOYSA-N
LogP	3.270
Indirect Additives used in Food Contact Substances	CHLOROXYLENOL
FDA 21 CFR	175.105; 310.545
CAS DataBase Reference	88-04-0(CAS DataBase Reference)
EWG's Food Scores	3
FDA UNII	0F32U78V2Q
ATC code	D08AE05
NIST Chemistry Reference	Chloroxylenol(88-04-0)
EPA Substance Registry System	4-Chloro-3,5-dimethylphenol (88-04-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H317-H319

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

22-36/38-43

Safety Statements

24-37

RIDADR

UN 3077 9/PG 3

WGK Germany

1

RTECS

ZE6850000

Hazard Note

Irritant

TSCA

Yes

HazardClass

9

PackingGroup

III

HS Code

29081000

Toxicity

LD50 orally in Rabbit: 3830 mg/kg

NFPA 704

	0
2		0

4-Chloro-3,5-dimethylphenol price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	BP080	Chloroxylenol British Pharmacopoeia (BP) Reference Standard	88-04-0	500MG	$220	2024-03-01	Buy
Sigma-Aldrich	8.18734	4-Chloro-3,5-dimethylphenol for synthesis	88-04-0	250g	$57.5	2024-03-01	Buy
Sigma-Aldrich	24380	4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T)	88-04-0	1kg	$74.8	2024-03-01	Buy
Sigma-Aldrich	1122700	Chloroxylenol United States Pharmacopeia (USP) Reference Standard	88-04-0	125mg	$161.2	2024-03-01	Buy
Sigma-Aldrich	24380	4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T)	88-04-0	50g	$27.4	2023-06-20	Buy

Product number	Packaging	Price	Buy
BP080	500MG	$220	Buy
8.18734	250g	$57.5	Buy
24380	1kg	$74.8	Buy
1122700	125mg	$161.2	Buy
24380	50g	$27.4	Buy

4-Chloro-3,5-dimethylphenol Chemical Properties,Uses,Production

Chemical Properties

White or cream-colored crystals or crystalline powder with a characteristic phenolic odor. Volatile in steam.

Chemical Properties

4-Chloro-3,5-dimethylphenol is white or cream crystalline powder with a characteristic odour

Originator

Septiderm ,Fougera ,US,1960

Uses

antibacterial, topical and urinary antiseptic

Uses

Antiseptic and germicide; for mildew prevention. Claimed to be about 60 times as potent as phenol.

Uses

4-Chloro-3,5-dimethylphenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).

Definition

ChEBI: 4-chloro-3,5-dimethylphenol is a member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores. It has a role as an antiseptic drug, a disinfectant and a molluscicide. It is a member of phenols and a member of monochlorobenzenes. It is functionally related to a 3,5-xylenol.

Production Methods

Chloroxylenol is prepared by treating 3,5-dimethylphenol with chlorine or sulfuryl chloride (SO₂Cl₂).

Manufacturing Process

546 g of intermediate xylenol fraction having a crystallizing point of 45°C mixed with an equal weight of m-5-xylenol are placed in a suitable vessel, equipped with stirring gear, and 273 g of sulfuryl chloride are added slowly. The temperature rises in the course of the reaction to about 40°C. When all the sulfuryl chloride is added the reaction mixture is heated to 80°C and theacid gases removed as far as possible by air-blowing or any other suitable means. On cooling a quantity of the required chlor-xylenol separates out and is removed from the mother liquor. Further quantities of the material required can be isolated by vacuum distillation of the mother liquors and further crystallization. In all, 200 to 208 g of material substantially 2-chlor-m-5- xylenol can be obtained having a melting point of 112°C to 115°C. The material can be purified if desired by crystallization from a solvent such as a hydrocarbon.

Therapeutic Function

Topical antiseptic; Disinfectant

General Description

The degradation of 4-chloro-3,5-dimethylphenol (PCMX) by Fenton-like process using nanoparticulate zero-valent iron (nZVI) and hydrogen peroxide (H₂O₂) was studied.

Pharmaceutical Applications

4-Chloro-3,5-dimethylphenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection.
As a pharmaceutical excipient, 4-Chloro-3,5-dimethylphenol is commonly used in low concentrations as an antimicrobial preservative in topical formulations such as creams and ointments. 4-Chloro-3,5-dimethylphenol is also used in a number of cosmetic formulations.
Therapeutically, 4-Chloro-3,5-dimethylphenol has been investigated as a treatment for acne vulgaris, for treating infected root canals, and as an antifungal agent when impregnated into medical devices. 4-Chloro-3,5-dimethylphenol is included in drug products approved for topical antifungal, topical acne and topical dandruff/seborrheic dermatitis/psoriasis treatments.

Agricultural Uses

Microbiocide: 4-Chloro-3,5-dimethylphenol was first registered in the U.S. for use as a fungicide and is now applied as an antimicrobial for control of bacteria, algae and fungi in adhesives, emulsions, paints and wash tanks. It is registered for use in household and domestic dwellings, laundry equipment, bathrooms, diaper pails and in industrial water and aqueous systems. Not listed for use in EU countries. Registered for use in the U.S. There are 64 global suppliers.

Trade name

BAR-FUNGAL PLUS®[C]; BIO SLIME®[C]; DESSON®; DETTOL®; ECOTRU®; ESPADOL®; HUSEPT®; HUSEPT EXTRA®; NIPACIDE®; OTTASEPT®[C]; OTTASEPT® EXTRA[C]; PCMX; RBA 777®

Clinical Use

p-Chloro-m-xylenol (PC-MX; Metasep) is a nonirritating antiseptic agent with broad-spectrum antibacterial and antifungal properties. It is marketed in a 2% concentration as a shampoo. It has also been used topically for the treatment of tinea (ringworm) infections such as athlete s foot (tinea pedis) and jock itch (tinea cruris).

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. An eye irritant. An antimicrobial agent. See also CHLOROPHENOLS and CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic fumes of Cl-.

Safety

Chloroxylenol is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient in topical products. However, chloroxylenol has been placed in Toxicity Category I for eye irritation effects. In addition, allergic skin reactions have been reported. Taken orally, chloroxylenol is mildly toxic and ingestion of a chloroxylenol-containing disinfectant product has been associated with reports of fatal or severe instances of selfpoisoning.
LD₅₀ (mouse, IP): 0.115 g/kg
LD₅₀ (rat, dermal): >2.0 g/kg
LD₅₀ (rat, oral): 3.83 g/kg

storage

Chloroxylenol is stable at normal room temperature, but is volatile in steam. Contact with natural rubber should be avoided. Aqueous solutions of chloroxylenol are susceptible to microbial contamination and appropriate measures should be taken to prevent contamination during storage or dilution. Chloroxylenol should be stored in polyethylene, mild steel or stainless steel containers, which should be well-closed and kept in a cool, dry place. Chloroxylenol does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours.

Purification Methods

Crystallise the phenol from *benzene or toluene. [Beilstein 6 IV 3152.]

Incompatibilities

4-Chloro-3,5-dimethylphenol has been reported to be incompatible with nonionic surfactants and methylcellulose.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic preparations; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK. Approved in Europe as a preservative in cosmetics with a maximum authorized concentration of 0.5%.

4-Chloro-3,5-dimethylphenol synthesis

Synthesis of 4-Chloro-3,5-dimethylphenol from 3,5-Dimethylphenol

4-Chloro-3,5-dimethylphenol Preparation Products And Raw materials

Raw materials

ZINC Xylenol Sulfuryl chloride CHLOROXYLENOL RELATED COMPOUND A (25 MG) (2- CHLORO-3,5-DIMETHYLPHENOL) 2,4-Dichloro-3,5-dimethylphenol

3,5-Dimethylphenol Chloroform

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Preparation Products

4-Chloro-3,5-dimethylphenol Suppliers

Global( 598)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Wuhan Xinhao Biotechnology Co., Ltd	+86-18120578002 +86-18120578002	xinhao-6@xinhaoshengwu.com	China	350	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	525	58
Shandong Juchuang Chemical Co., LTD	+86-18885615001 +86-18885615001	admin@juchuangchem.com	China	387	58
Shanghai Aosiris new Material Technology Co., LTD	86-15139564871 +8615139564871	wrjmoon2000@163.com	China	354	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58

Supplier	Advantage
Jinan Finer Chemical Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Wuhan Xinhao Biotechnology Co., Ltd	58
Sigma Audley	58
Shandong Juchuang Chemical Co., LTD	58
Shanghai Aosiris new Material Technology Co., LTD	58
hebei hongtan Biotechnology Co., Ltd	58

View Lastest Price from 4-Chloro-3,5-dimethylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	4-Chloro-3,5-dimethylphenol 88-04-0	US $20.00-5.00 / kg	1kg	99%	300tons	Hebei Dangtong Import and export Co LTD
2024-04-24	4-Chloro-3,5-dimethylphenol 88-04-0	US $0.00 / KG	1KG	995	500mt	Jinan Finer Chemical Co., Ltd
2024-04-22	4-Chloro-3,5-dimethylphenol 88-04-0	US $10.00 / kg	1kg	99%	2000kg	hebei hongtan Biotechnology Co., Ltd

4-Chloro-3,5-dimethylphenol
88-04-0
US $20.00-5.00 / kg
99%
Hebei Dangtong Import and export Co LTD

4-Chloro-3,5-dimethylphenol
88-04-0
US $0.00 / KG
995
Jinan Finer Chemical Co., Ltd

4-Chloro-3,5-dimethylphenol
88-04-0
US $10.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

4-Chloro-3,5-dimethylphenol Spectrum

4-Chloro-3,5-dimethylphenol(88-04-0)MS 4-Chloro-3,5-dimethylphenol(88-04-0)¹HNMR 4-Chloro-3,5-dimethylphenol(88-04-0)¹³CNMR 4-Chloro-3,5-dimethylphenol(88-04-0)IR1 4-Chloro-3,5-dimethylphenol(88-04-0)IR2 4-Chloro-3,5-dimethylphenol(88-04-0)Raman

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Dettol, liquid antiseptic Espadol Husept extra huseptextra Nipacide mx Nipacide PX Ottasept Ottasept extra ottaseptextra Parametaxylenol p-Chloro-3,5-xylenol p-chloro-m-xylenol-phenol Phenol, 4-chloro-3,5-dimethyl- Rba 777 rba777 Septiderm-hydrochloride Willenol V Xylenol, 4-chloro- 2-Chloro-m-xylenol 3,5-Xylenol, 4-chloro- 4-CHLORO-META-XYLENOL 4-CHLORO-3,5-XYLENOL 99+% 27) PARA CHLORO META XYLENOL 4-Chloro-3,5-diMethylphenol puruM, >=98.0% (T) Between the chlorine diMethyl phenol 4-Chloro-3.5-d 2,6-DiMethyl-4-hydroxy-1-chlorobenzene 4-Chloro-5,3-diMethylphenol 4 chloro 3,5 diMethylphenol p-Chloro-M-xylenol Chloro-3,5-diMethylp P-Chloro-M-Xylenol (PCMX), 4-Chloro-3,5-diMethylphenol Dett germicide 4-Chloro-3,5-dimethylphenol, 98+% 4-Chloro-3,5-dimethylphenol,99% 4-Chloro-3,5-dimethylphenol,4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol Chloroxylenol (125 mg) 4-Chloro-3,5-dimethy 4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol 4-Chloro-3,5-diMethylphenol, 99% 100GR Ayrtol Benzytol Camel Chloro-3,5-dimethylphenol Chloro-3,5-xylenol Chloro-5-hydroxy-m-xylene Chloro-m-xylenol Chloroxylend Desson BENZYLTOL CHLORO-SYM-XYLENOL 3,5-DIMETHYL-4-CHLORO PHENOL 4-CHLORO-3,5-DIMETHYLPHENOL 4-CHLORO-SYM-M-XYLENOL 4-Chloro-1-hydroxy-3,5-dimethylbenzene 4-chloro-3,5-dimethyl-pheno 4-Chloro-3,5-xylenol GL 4-Chloro-3-xylenol 4-chloro-5-xylenol