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4-Chloro-3,5-dimethylphenol

4-Chloro-3,5-dimethylphenol
4-Chloro-3,5-dimethylphenol structure
CAS No.
88-04-0
Chemical Name:
4-Chloro-3,5-dimethylphenol
Synonyms
PCMX;Camel;Ayrtol;Desson;Dettol;rba777;Espadol;Rba 777;Benzytol;Ottasept
CBNumber:
CB2666624
Molecular Formula:
C8H9ClO
Formula Weight:
156.61
MOL File:
88-04-0.mol

4-Chloro-3,5-dimethylphenol Properties

Melting point:
114-116 °C(lit.)
Boiling point:
246 °C
Density 
0.67 g/cm3
refractive index 
1.5523 (estimate)
Flash point:
132 °C
storage temp. 
2-8°C
solubility 
methanol: soluble1g/10 mL, clear to faintly turbid, colorless to very faintly yellow
form 
Crystalline Powder or Crystals
pka
9.76±0.23(Predicted)
color 
White to light beige
PH
7 (0.2g/l, H2O)
Water Solubility 
0.3 g/L (20 ºC)
Merck 
14,2176
BRN 
1862539
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
OSDLLIBGSJNGJE-UHFFFAOYSA-N
Indirect Additives used in Food Contact Substances
CHLOROXYLENOL
CAS DataBase Reference
88-04-0(CAS DataBase Reference)
FDA 21 CFR
175.105; 310.545
EWG's Food Scores
3
FDA UNII
0F32U78V2Q
NIST Chemistry Reference
Chloroxylenol(88-04-0)
EPA Substance Registry System
4-Chloro-3,5-dimethylphenol (88-04-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H315-H317-H319-H303-H410
Precautionary statements  P280-P301+P312+P330-P305+P351+P338-P261-P264-P272-P273-P302+P352+P333+P313+P363-P305+P351+P338+P337+P313-P391-P501-P280a-P321-P333+P313-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-43
Safety Statements  24-37
RIDADR  UN 3077 9/PG 3
WGK Germany  1
RTECS  ZE6850000
Hazard Note  Irritant
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29081000
Toxicity LD50 orally in Rabbit: 3830 mg/kg

4-Chloro-3,5-dimethylphenol price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 24380 4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T) 88-04-0 1kg-f $147 2019-12-02 Buy
Sigma-Aldrich 1122700 Chloroxylenol United States Pharmacopeia (USP) Reference Standard 88-04-0 125mg $325.85 2019-12-02 Buy
TCI Chemical C0161 4-Chloro-3,5-dimethylphenol >98.0%(GC) 88-04-0 25g $19 2020-06-24 Buy
TCI Chemical C0161 4-Chloro-3,5-dimethylphenol >98.0%(GC) 88-04-0 500g $90 2020-06-24 Buy
Alfa Aesar B21964 4-Chloro-3,5-dimethylphenol, 98+% 88-04-0 500g $71 2020-06-24 Buy

4-Chloro-3,5-dimethylphenol Chemical Properties,Uses,Production

Chemical Properties

4-Chloro-3,5-dimethylphenol is white or cream crystalline powder with a characteristic odour

Chemical Properties

White or cream-colored crystals or crystalline powder with a characteristic phenolic odor. Volatile in steam.

Uses

antibacterial, topical and urinary antiseptic

Uses

4-Chloro-3,5-dimethylphenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).

Uses

Antiseptic and germicide; for mildew prevention. Claimed to be about 60 times as potent as phenol.

Production Methods

Chloroxylenol is prepared by treating 3,5-dimethylphenol with chlorine or sulfuryl chloride (SO2Cl2).

Agricultural Uses

Microbiocide: 4-Chloro-3,5-dimethylphenol was first registered in the U.S. for use as a fungicide and is now applied as an antimicrobial for control of bacteria, algae and fungi in adhesives, emulsions, paints and wash tanks. It is registered for use in household and domestic dwellings, laundry equipment, bathrooms, diaper pails and in industrial water and aqueous systems. Not listed for use in EU countries. Registered for use in the U.S. There are 64 global suppliers.

Pharmaceutical Applications

4-Chloro-3,5-dimethylphenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection.
As a pharmaceutical excipient, 4-Chloro-3,5-dimethylphenol is commonly used in low concentrations as an antimicrobial preservative in topical formulations such as creams and ointments. 4-Chloro-3,5-dimethylphenol is also used in a number of cosmetic formulations.
Therapeutically, 4-Chloro-3,5-dimethylphenol has been investigated as a treatment for acne vulgaris, for treating infected root canals, and as an antifungal agent when impregnated into medical devices. 4-Chloro-3,5-dimethylphenol is included in drug products approved for topical antifungal, topical acne and topical dandruff/seborrheic dermatitis/psoriasis treatments.

Trade name

BAR-FUNGAL PLUS®[C]; BIO SLIME®[C]; DESSON®; DETTOL®; ECOTRU®; ESPADOL®; HUSEPT®; HUSEPT EXTRA®; NIPACIDE®; OTTASEPT®[C]; OTTASEPT® EXTRA[C]; PCMX; RBA 777®

Clinical Use

p-Chloro-m-xylenol (PC-MX; Metasep) is a nonirritating antiseptic agent with broad-spectrum antibacterial and antifungal properties. It is marketed in a 2% concentration as a shampoo. It has also been used topically for the treatment of tinea (ringworm) infections such as athlete s foot (tinea pedis) and jock itch (tinea cruris).

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. An eye irritant. An antimicrobial agent. See also CHLOROPHENOLS and CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic fumes of Cl-.

Safety

Chloroxylenol is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient in topical products. However, chloroxylenol has been placed in Toxicity Category I for eye irritation effects. In addition, allergic skin reactions have been reported. Taken orally, chloroxylenol is mildly toxic and ingestion of a chloroxylenol-containing disinfectant product has been associated with reports of fatal or severe instances of selfpoisoning.
LD50 (mouse, IP): 0.115 g/kg
LD50 (rat, dermal): >2.0 g/kg
LD50 (rat, oral): 3.83 g/kg

storage

Chloroxylenol is stable at normal room temperature, but is volatile in steam. Contact with natural rubber should be avoided. Aqueous solutions of chloroxylenol are susceptible to microbial contamination and appropriate measures should be taken to prevent contamination during storage or dilution. Chloroxylenol should be stored in polyethylene, mild steel or stainless steel containers, which should be well-closed and kept in a cool, dry place. Chloroxylenol does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours.

Purification Methods

Crystallise the phenol from *benzene or toluene. [Beilstein 6 IV 3152.]

Incompatibilities

4-Chloro-3,5-dimethylphenol has been reported to be incompatible with nonionic surfactants and methylcellulose.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic preparations; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK. Approved in Europe as a preservative in cosmetics with a maximum authorized concentration of 0.5%.

4-Chloro-3,5-dimethylphenol Preparation Products And Raw materials

Raw materials

Preparation Products


4-Chloro-3,5-dimethylphenol Suppliers

Global( 333)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2678 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3269 55
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 4895 58
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 xtchem2019@gmail.com CHINA 288 58
YANGZHOU SHUANGDING CHEM CO., LTD
18051432592 0514-83613866
0514-83423334 Alice@shuangdingchem.com CHINA 49 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58

View Lastest Price from 4-Chloro-3,5-dimethylphenol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-11-11 4-Chloro-3,5-dimethylphenol
88-04-0
US $3.00 / KG 1KG 99% 10MT Henan Xiangtong Chemical Co., Ltd.
2020-07-27 4-Chloro-3,5-dimethylphenol
88-04-0
US $0.00 / KG 1KG 995 500mt Jinan Finer Chemical Co., Ltd
2020-07-17 4-Chloro-3,5-dimethylphenol
88-04-0
US $0.00 / Kg/Drum 200KG >99% 200 tons/year YANGZHOU SHUANGDING CHEM CO., LTD

4-Chloro-3,5-dimethylphenol Spectrum


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