CLOPERASTINE
- CAS No.
- 3703-76-2
- Chemical Name:
- CLOPERASTINE
- Synonyms
- CLOPERASTINE;CLOPERASTINE USP/EP/BP;Cloperastine (base and/or unspecified salts);p-Chlorobenzhydryl2-(1-piperidyl)-ethyl ether;1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine;1-[2-(p-Chloro-α-phenylbenzyloxy)ethyl]piperidine;1-[2-[(p-Chloro-α-phenylbenzyl)oxy]ethyl]piperidine;1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)piperidine;1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-piperidin;1-[2-[[4-Chloro-α-(phenyl)benzyl]oxy]ethyl]piperidine
- CBNumber:
- CB2670438
- Molecular Formula:
- C20H24ClNO
- Molecular Weight:
- 329.87
- MDL Number:
- MFCD00866854
- MOL File:
- 3703-76-2.mol
| Boiling point | bp0.06 172-174°; bp0.15 178-180° |
|---|---|
| Density | 1.0383 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| pka | 8.69±0.10(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | 69M5L7BXEK |
| ATC code | R05DB21 |
CLOPERASTINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C587215 | Cloperastine | 3703-76-2 | 500mg | $60 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008669 | CLOPERASTINE 95.00% | 3703-76-2 | 5MG | $499.19 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008669 | CLOPERASTINE 95.00% | 3703-76-2 | 1G | $1575 | 2021-12-16 | Buy |
| Alichem | 3703762 | 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine | 3703-76-2 | 1g | $690.8 | 2021-12-16 | Buy |
| Chemenu | CM180441 | 1-(2-((4-chlorophenyl)(phenyl)methoxy)ethyl)piperidine 95% | 3703-76-2 | 1g | $729 | 2021-12-16 | Buy |
CLOPERASTINE Chemical Properties,Uses,Production
Originator
Hustazol,Yoshitomi,Japan,1972
Uses
Cloperastine Hydrochloride (C587213) is an anti-tussive drug as an over-the-counter cold medicine.
Definition
ChEBI: 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine is a diarylmethane.
Manufacturing Process
The manufacture of a related compound is first described. 28.1 parts of pchloro-benzhydryl bromide are heated to boiling, under reflux and with
stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of calcined
sodium carbonate. The reaction product is extracted with ether and the
ethereal solution washed with water and dilute hydrochloric acid. The residue
from the solution in ether boils at 134° to 137°C under 0.2 mm pressure and
is p-chloro-benzhydryl-(β-chloroethyl)ether.
28.1 parts of this ether are heated with 12 parts of methylethylamine (100%)
in a sealed tube for 4 hours at 110°C. The product of the reaction is extracted
several times with dilute hydrochloric acid, the acid solution made alkaline, in
the cold, with concentrated caustic soda solution and the base which
separates taken up in ether. The ether extract is washed with concentrated
potassium carbonate solution, evaporated down, and the residue distilled in
vacuo. The product is β-methylethyl aminoethyl p-chlorobenzhydryl ether, BP
152° to 153°C/0.1 mm.
Reaction with dimethylethylamine instead of methylethylamine leads directly
to a quaternary compound, which type of compound can also be obtained by
reacting the tertiary aminoethyl ether with reactive esters
If 18 parts of piperidine are used instead of 12 parts of methylethylamine
then the same procedure results in the formation of p-chloro-benzyhydril-(β-
piperidino-ethyl)ether, boiling at 178° to 180°C under 0.15 mm pressure.
Therapeutic Function
Antitussive
CLOPERASTINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3632 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9358 | 58 |
| Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 | info@chemsigma.com | China | 963 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from CLOPERASTINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-01 | CLOPERASTINE
3703-76-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-07-10 | Cloperastine
3703-76-2
|
US $102.00-88.00 / g | 10g | 99% | 10kg | Jiangsu Boquan Biotechnology Co., Ltd. | |
 |
2021-07-20 | Cloperastine
3703-76-2
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- CLOPERASTINE
3703-76-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Cloperastine
3703-76-2
- US $102.00-88.00 / g
- 99%
- Jiangsu Boquan Biotechnology Co., Ltd.
-
- Cloperastine
3703-76-2
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd