CYTOCHALASIN D
- CAS No.
- 22144-77-0
- Chemical Name:
- CYTOCHALASIN D
- Synonyms
- Nsc209835;ZYGOSPORIN A;Lygosporin a;Cytohalasin d;CYTOCHALACIND;CYTOCHALICIND;CYTOCHALASIN D;19-trien-17-one;CYTOCHALASIN D(RG);InSolution? Cytochalasin D,
- CBNumber:
- CB2672937
- Molecular Formula:
- C30H37NO6
- Molecular Weight:
- 507.62
- MDL Number:
- MFCD00077706
- MOL File:
- 22144-77-0.mol
- MSDS File:
- SDS
| Melting point | 255-260°C |
|---|---|
| Boiling point | 595.84°C (rough estimate) |
| Density | 1.1764 (rough estimate) |
| refractive index | 1.6310 (estimate) |
| Flash point | 87℃ |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| pka | 11.95±0.70(Predicted) |
| form | White solid |
| color | White |
| BRN | 1632828 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| LogP | 2.640 (est) |
| FDA UNII | SY9F0FZ3TO |
| EPA Substance Registry System | Cytochalasin D (22144-77-0) |
CYTOCHALASIN D price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C2618 | Cytochalasin D Ready Made Solution, from Zygosporium mansonii, 5?mg/mL in DMSO, 0.2 μm filtered | 22144-77-0 | 200μL | $217 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.04776 | InSolution Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem | 22144-77-0 | 1mg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 11330 | Cytochalasin D ≥95% | 22144-77-0 | 1mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 11330 | Cytochalasin D ≥95% | 22144-77-0 | 5mg | $260 | 2024-03-01 | Buy |
| Sigma-Aldrich | C8273 | Cytochalasin D from Zygosporium mansonii, ≥98% (TLC and HPLC), powder | 22144-77-0 | 1mg | $163 | 2024-03-01 | Buy |
CYTOCHALASIN D Chemical Properties,Uses,Production
Description
Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across cell membranes. Disruption of actin microfilaments leads to activation of p53. Cell permeable
Chemical Properties
Powder
Uses
A cell cycle arresting compound used in actin polymerization studies and cytological research
Uses
Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumour agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
Uses
Cytochalasin D acts as an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhib itor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.
Definition
ChEBI: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
General Description
Needles or fluffy white powder.
Reactivity Profile
CYTOCHALASIN D may be sensitive to exposure to heat. CYTOCHALASIN D can react with strong oxidizing agents, strong acids and strong bases. .
Fire Hazard
Flash point data for CYTOCHALASIN D are not available; however, CYTOCHALASIN D is probably combustible.
Biological Activity
Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B, does not inhibit monosaccharide transport across the plasma membrane.
Biochem/physiol Actions
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
target
p38MAPK | PI3K | Akt | Calcium Channel | ATPase
storage
Store at -20°C
References
1)) Goddetteand et al. (1986), Actin polymerization. The mechanism of action of cytochalasin D; J. Biol. Chem., 261 15974 2) Rubtsova et al. (1998), Disruption of actin microfilaments by cytochalasin D leads to activation of p53; FEBS Lett., 430 353
CYTOCHALASIN D Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
View Lastest Price from CYTOCHALASIN D manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | CYTOCHALASIN D
22144-77-0
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
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- CYTOCHALASIN D
22144-77-0
- US $1.00 / kg
- 99%
- Career Henan Chemical Co