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Denatonium Benzoate Anhydrous

The most bitter compound in the world Chemical structure Uses
Denatonium Benzoate Anhydrous
Denatonium Benzoate Anhydrous structure
Chemical Name:
Denatonium Benzoate Anhydrous
Molecular Formula:
Formula Weight:
MOL File:

Denatonium Benzoate Anhydrous Properties

Melting point:
164-168 °C(lit.)
Boiling point:
555.91°C (rough estimate)
1.1256 (rough estimate)
refractive index 
1.5800 (estimate)
Flash point:
methanol: 50 mg/mL, clear, colorless
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
3734-33-6(CAS DataBase Reference)
EWG's Food Scores
EPA Substance Registry System
Denatonium benzoate (3734-33-6)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302-H413-H335-H315-H319
Precautionary statements  P264-P270-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P301+P312+P330-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36-37/39
WGK Germany  2
RTECS  BO6650000
HS Code  29242995

Denatonium Benzoate Anhydrous price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 52487 Denatonium benzoate analytical standard 3734-33-6 100mg $80 2019-12-02 Buy
Sigma-Aldrich 1171003 Denatonium benzoate United States Pharmacopeia (USP) Reference Standard 3734-33-6 200mg $352.8 2019-12-02 Buy
TCI Chemical D2124 Denatonium Benzoate >98.0%(HPLC) 3734-33-6 5g $58 2020-06-24 Buy
TCI Chemical D2124 Denatonium Benzoate >98.0%(HPLC) 3734-33-6 25g $173 2020-06-24 Buy
Alfa Aesar J61048 Denatonium benzoate 3734-33-6 5g $80.4 2020-06-24 Buy

Denatonium Benzoate Anhydrous Chemical Properties,Uses,Production

The most bitter compound in the world

Denatonium benzoate is now known as the world's most bitter compound. If we set the bitter degree of quinine as datum 1, the degree of bitterness of the product would be 1000. A concentration of 10ppm solution is already too bitter to bear for most people. The vast majority of its applications are related to its bitter flavor. It is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit.
Denatonium benzoate is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance. For example, it has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, it has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear.

Chemical structure

Denatonium benzoate is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion. The structure of its cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino.


Flavoring agent.

Chemical Properties

white crystals

Chemical Properties

Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules.


H1 antihistamine


Pharmaceutic aid (alcohol denaturant; flavor). Added to toxic substances as a deterrent to accidental ingestion. Can replace brucine or quassin as denaturant for ethyl alcohol.

Production Methods

Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.

brand name

Bitrex (Mac Farlan Smith, Scotland).

Pharmaceutical Applications

Denatonium benzoate is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. It is most commonly used at levels of 5–500 ppm. Denatonium benzoate may also be used to replace brucine or quassin as a denaturant for ethanol.
In pharmaceutical formulations, denatonium benzoate has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation.


Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg


Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.


Denatonium benzoateis incompatible with strongoxidizing agents.

Regulatory Status

Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).

Denatonium Benzoate Anhydrous Preparation Products And Raw materials

Raw materials

Preparation Products

Denatonium Benzoate Anhydrous Suppliers

Global( 270)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhejiang Synose Tech Co., Ltd
86-579-82275537 CHINA 218 58
Shanghai Worldyang Chemical Co.,Ltd.
+86-13651600618,+86-21-56795779 CHINA 820 58
BOC Sciences
1-631-614-7828 United States 20039 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22625 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 24754 60
Speranza Chemical Co., Ltd.
+86-755-33122716 CHINA 309 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 2678 55
career henan chemical co
+86-371-86658258 CHINA 30043 58

View Lastest Price from Denatonium Benzoate Anhydrous manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-17 denatonium benzoate
US $10.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2020-07-23 Denatonium Benzoate/Benzoate
US $150.00 / KG 1KG 99.6% 600kg/month Hebei Huanhao Biotechnology Co., Ltd.
2020-07-22 denatonium benzoate
US $110.00 / KG 10g 99.8% 500kg/month Hebei Huanhao Biotechnology Co., Ltd.

Denatonium Benzoate Anhydrous Spectrum

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