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Diosgenin

Diosgenin
Diosgenin structure
CAS No.
512-04-9
Chemical Name:
Diosgenin
Synonyms
SP 37;Diosg;C08898;diosgen;Diosgemom;(3β,25R)-;DIOSGENIN;NITOGENIN;SAPOGENIN;Nitrogenin
CBNumber:
CB2685481
Molecular Formula:
C27H42O3
Formula Weight:
414.63
MOL File:
512-04-9.mol

Diosgenin Properties

Melting point:
205-208°C
Boiling point:
473.46°C (rough estimate)
alpha 
D25 -129° (c = 1.4 in CHCl3)
Density 
1.0483 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
2-8°C
solubility 
chloroform: 20 mg/mL, clear, slightly yellow
pka
15.02±0.70(Predicted)
Water Solubility 
Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol.
Merck 
14,3295
BRN 
94582
CAS DataBase Reference
512-04-9(CAS DataBase Reference)
FDA UNII
K49P2K8WLX
NIST Chemistry Reference
Diosgenin(512-04-9)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37-24/25
WGK Germany  2
RTECS  WH1450000
HS Code  29329990

Diosgenin price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1634 Diosgenin ≥93% 512-04-9 5g $57.1 2021-03-22 Buy
Sigma-Aldrich D1634 Diosgenin ≥93% 512-04-9 100g $632 2021-03-22 Buy
TCI Chemical D1474 Diosgenin >95.0%(GC) 512-04-9 1g $21 2021-03-22 Buy
TCI Chemical D1474 Diosgenin >95.0%(GC) 512-04-9 10g $73 2021-03-22 Buy
Alfa Aesar J60976 Diosgenin 512-04-9 25g $114 2021-03-22 Buy

Diosgenin Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Dolid

Uses

antiinflammatory, estrogen

Uses

Aglicone of saponin dioscin. Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. e and Progesterone.

Uses

pregnenolone and progesterone precursor

Anticancer Research

It is a steroidal saponin and legumes and yams are the rich sources of it. It is a notoriousprecursor of several synthetic steroidal drugs. It suppresses growth of cells andinduces apoptosis in human osteosarcoma, colon cancer, and leukemia. Its anticancermechanism is by arresting the cell cycle, disrupting the calcium homeostasis,activating p53, releasing apoptosis inducing factors, and modulating caspase-3activity. It suppresses NF-κB activation induced by TNF as a result of DNA binding,IκBα kinase activation, degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It suppresses proliferation and invasion and induces apoptosisby downregulation of cFLIP, cyclin-D1, TRAF1, COX-2, c-myc, Bfl-1/A1, BclxL,IAP1, Bcl-2, and MMP-9 (Aggarwal et al. 2008; Raju and Mehta 2008).

Purification Methods

Crystallise diosgenin from acetone, and chromatograph it on Al2O3 and elute with *C6H6/Et2O (9:1), then recrystallise it from MeOH. Its solubility is ~4% in H2O and 5% in CHCl3. The acetate crystallises from AcOH with m 198o; and has [] D 20 -119o (pyridine). [Marker et al. J Am Chem Soc 65 1199 1943. Mazur et al. J Am Chem Soc 82 5889 1960, Beilstein 19 IV 862.]

Diosgenin Preparation Products And Raw materials

Raw materials

Preparation Products


Diosgenin Suppliers

Global( 420)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20911 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58

View Lastest Price from Diosgenin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-17 Diosgenin 512-04-9
512-04-9
US $15.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-13 Diosgenin
512-04-9
US $10.00 / KG 10g 99 50 Ton/Tons per Month Shijiazhuang tongyang Import and Export Co., LTD
2021-07-31 diosgenin
512-04-9
US $25.00 / KG 1KG 6%98% 100kg Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.

Diosgenin Spectrum


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