BRL 54443
- CAS No.
- 57477-39-1
- Chemical Name:
- BRL 54443
- Synonyms
- CS-1781;BRL 54443;BRL 54443 HCl;BRL 54443, >=98%;BRL-54443;BRL54443;BRL 54443 USP/EP/BP;BRL54443;BRL 54443;BRL-54443;3-(1-methylpiperidin-4-yl)-1H-indol-5-ol;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol;1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-
- CBNumber:
- CB2690838
- Molecular Formula:
- C14H18N2O
- Molecular Weight:
- 230.31
- MDL Number:
- MFCD01861184
- MOL File:
- Mol file
- MSDS File:
- SDS
| Boiling point | 431.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.196 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL |
| form | solid |
| pka | 10.08±0.40(Predicted) |
| color | white |
| FDA UNII | Q2DH1CHI0Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BRL 54443 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21263 | BRL 54443 ≥98% | 57477-39-1 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 21263 | BRL 54443 ≥98% | 57477-39-1 | 10mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 21263 | BRL 54443 ≥98% | 57477-39-1 | 25mg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 21263 | BRL 54443 ≥98% | 57477-39-1 | 50mg | $384 | 2024-03-01 | Buy |
| Tocris | 1129 | BRL54443 | 57477-39-1 | 50 | $495 | 2021-12-16 | Buy |
BRL 54443 Chemical Properties,Uses,Production
Uses
BRL-53443 is a potent 5-HT and dopamine receptor agonist. Neuroresearch product.
Definition
ChEBI: 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles.
Biological Activity
A potent 5-ht 1E/1F receptor agonist (pEC 50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK i values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT 1E , 1F , 1A , 1B , 1D , 2A , 2B , 2C , 4 , 7 , D 2 and D 3 receptors respectively). Induces 5-HT 2A receptor-mediated mouse aortic contraction in vitro (pEC 50 = 6.52). Active in vivo .
storage
+4°C (desiccate)
References
1. a.m. brown, k. avenell, t j. young et al. brl 54443, a potent agonist with selectivity for human cloned 5-ht1e and 5-ht1f receptors. 1998. br.j.pharmacol. 123 233p.2. s. lightowler, t. stean, n. upton et al. effect of brl 54443 (3-(1-methylpiperidin-4-yl)-1h-indol-5-ol), a 5-ht1e/1f receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. 1998. br.j.pharmacol. 123 237p.3. mckune cm, watts sw. characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. j pharmacol exp ther. 2001 apr;297(1):88-95.4. janssen p, tack j, sifrim d et al. influence of 5-ht1 receptor agonists on feline stomach relaxation. eur j pharmacol. 2004 may 25;492(2-3):259-67.
BRL 54443 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from BRL 54443 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-14 | Cobicistat
57477-39-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | BRL 54443
57477-39-1
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Cobicistat
57477-39-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- BRL 54443
57477-39-1
- US $2.00 / kg
- 99%
- Career Henan Chemical Co