Hypericin
- CAS No.
- 548-04-9
- Chemical Name:
- Hypericin
- Synonyms
- Hypericins;Hyperici;Hypericine;VIMRxyn;CYCLOSAN;ypericin;HYPERICIN;MYCOPOPHYRIN;CYCLO-WERROL;HYPERICIN(P)
- CBNumber:
- CB2696784
- Molecular Formula:
- C30H16O8
- Molecular Weight:
- 504.44
- MDL Number:
- MFCD00016683
- MOL File:
- 548-04-9.mol
- MSDS File:
- SDS
| Melting point | 299-301°C |
|---|---|
| Boiling point | 1020.3±65.0 °C(Predicted) |
| Density | 1.915±0.06 g/cm3(Predicted) |
| RTECS | SF8472000 |
| storage temp. | -20°C |
| solubility | 1 M NaOH: 10 mg/mL |
| form | powder |
| pka | 6.91±0.20(Predicted) |
| color | black |
| Water Solubility | Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water. |
| Sensitive | Light Sensitive |
| Merck | 14,4863 |
| BRN | 1917913 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | BTXNYTINYBABQR-UHFFFAOYSA-N |
| LogP | 10.827 (est) |
| CAS DataBase Reference | 548-04-9(CAS DataBase Reference) |
| FDA UNII | 7V2F1075HD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-40-43 | |||||||||
| Safety Statements | 22-36-36/37 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8 | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
Hypericin price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89226 | Hypericin phyproof? Reference Substance | 548-04-9 | 10mg | $688 | 2024-03-01 | Buy |
| Sigma-Aldrich | 00190585 | Hypericin primary pharmaceutical reference standard | 548-04-9 | 10mg | $922 | 2024-03-01 | Buy |
| Alfa Aesar | H26425 | Hypericin, 98% | 548-04-9 | 25mg | $750 | 2024-03-01 | Buy |
| Alfa Aesar | H26425 | Hypericin, 98% | 548-04-9 | 100mg | $1716 | 2024-03-01 | Buy |
| Cayman Chemical | 11334 | Hypericin ≥95% | 548-04-9 | 500μg | $27 | 2024-03-01 | Buy |
Hypericin Chemical Properties,Uses,Production
Hypericum perforatum extracts
Hypericin is an extract of Hypericum perforatum L.In 1957. It is first isolated from the Garcinia species Hypericum perforatum by human beings. Hypericin belongs to the bianthrone compounds, and it is the most biologically active substances. Hypericin is a yellowish brown to brown mobile powder, with slightly bitter taste. It is soluble in water, and can emit a special fragrance. It can inhibit the central nervous and has a sedative effect. Adding it to health care products can enhance immunity. It is also used as antidepressant drugs in Europe (especially in Germany). Hypericin also has a strong anti-viral effect, which can directly act on swine fever, foot and mouth disease and other viruses. In addition, it also has a good effect on killing highly pathogenic avian influenza virus.
Hypericum perforatum is one of the world's best-selling herbs in recent years, mainly containing hyperoside, quercetin, chlorogenic acid, caffeic acid, imanin, hypericin and other ingredients.
Hypericin is a few thousandths of the whole Hypericum perforatum. There are certain requirements for its extraction and testing. Methanol extraction method is common used in the past. Due to the toxicity of methanol, now the method is converted to use ethanol to obtain the active ingredient.
Indications
Hypericin is an anti-virus and pure Chinese medicine preparations. It is the first choice for the prevention and treatment of avian influenza drugs.
1, avian influenza, atypical Newcastle disease, infectious bronchitis, avian infectious laryngotracheitis , bursa of Fabricius, duck plague, duck viral hepatitis, egg drop syndrome and other viral diseases.
2, poultry fever caused by high fever, dyspnea, cough, head and face swelling, crown hair purple, lack of energy, decreased feed intake, egg drop, producing more abnormal eggs.
3, for classical swine fever, blue ear disease, parvovirus, viral enteritis, infectious gastroenteritis and immune dysfunction.
4, Hypericin has a strong anti-viral effect both in vivo and in vitro. It has a strong inhibitory effect on the early replication of HIV. Hypericin can lead to cancer cell programmed death, with anti-cancer effect. It has a enhanced immune function for activating mononuclear phagocytic cells. In addition, it has a strong role in killing the highly pathogenic H5N1 and H9N2 subtype of avian influenza virus.
Uses
(1) Antidepressant, increase immunity.
(2) For the treatment of antidepressants, increase immunity.
Description
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.
Chemical Properties
Powder
Uses
It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.
Definition
ChEBI: Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene.
General Description
Produced by HWI Analytik
Exact content can be found on the certificate
Biological Activity
Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.
Biochem/physiol Actions
Primary TargetPKC
storage
+4°C
Purification Methods
Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]
References
1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775
Hypericin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huanfu Industrial Co.，（Shanghai）Ltd. | +86-18001856580 +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 | sarah@tnjone.com | China | 874 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Related articles
- Application of Hypericin
- Hypericin is a naturally occurring substance found in the common St. John's Wort (Hypericum species) and can also be synthesiz....
- Sep 19，2019
View Lastest Price from Hypericin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | St. John\'s Wort Extract
548-04-9
|
US $10.00 / kg | 1kg | Hypericin 0.3%UV | 10000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-04-23 | hypericin
548-04-9
|
US $0.00 / g | 10g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-04-12 | Hypericin
548-04-9
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
-
- St. John\'s Wort Extract
548-04-9
- US $10.00 / kg
- Hypericin 0.3%UV
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- hypericin
548-04-9
- US $0.00 / g
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Hypericin
548-04-9
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
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