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Difluoroacetic acid

Difluoroacetic acid structure

CAS No.: 381-73-7

Chemical Name:: Difluoroacetic acid

Synonyms: 2,2-DIFLUOROACETIC ACID;DIFLUOROACETATE;ifluoroaceticaci;VITAS-BB TBB000649;difluoro-aceticaci;DIFLUOROACETIC ACID;Difluoroaceticacid98%;Acetic acid, difluoro-;1,1-DIFLUOROACETIC ACID;Twotrifluoroacetic acid

CBNumber:: CB2700577

Molecular Formula:: C2H2F2O2

Molecular Weight:: 96.03

MDL Number:: MFCD00004220

MOL File:: 381-73-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-10 10:27:09

Product description	Number	Pack Size	Price
Difluoroacetic acid 98%	142859	5g	$86.5
Difluoroacetic acid 98%	142859	25g	$210
Difluoroacetic acid for LC-MS LiChropur^™, ≥97.5% (GC)	00922	1 mL	$52
Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC)	00922	10X1ML	$320
Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC)	00922	50ML	$1020
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Difluoroacetic acid Properties

Melting point	-1 °C (lit.)
Boiling point	132-134 °C (lit.)
Density	1.526 g/mL at 25 °C (lit.)
vapor pressure	11.7hPa at 25℃
refractive index	n20/D 1.344(lit.)
Flash point	174 °F
storage temp.	2-8°C
solubility	540.54g/L in organic solvents at 20 ℃
pka	pK1:1.33 (25°C)
form	Liquid
color	Clear colorless to light brown
Specific Gravity	1.527 (20℃)
Water Solubility	1000g/L at 37℃
BRN	1098588
Henry's Law Constant	3.0×10² mol/(m³Pa) at 25℃, Burkholder et al. (2019)
InChI	1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChIKey	PBWZKZYHONABLN-UHFFFAOYSA-N
SMILES	OC(=O)C(F)F
LogP	0.601 at 37℃
CAS DataBase Reference	381-73-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	ZQK1C95K3N
NIST Chemistry Reference	Difluoroacetic acid(381-73-7)
EPA Substance Registry System	Acetic acid, difluoro- (381-73-7)
UNSPSC Code	41116004
NACRES	NB.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H314-H332-H412

Precautionary statements

P261-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

34-35

Safety Statements

26-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

RTECS

AG9900000

Hazard Note

Corrosive

TSCA

TSCA listed

HazardClass

PackingGroup

HS Code

29159080

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Inhalation
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1A

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
3		0

Difluoroacetic acid price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	142859	Difluoroacetic acid 98%	381-73-7	5g	$86.5	2026-04-30	Buy
Sigma-Aldrich	142859	Difluoroacetic acid 98%	381-73-7	25g	$210	2026-04-30	Buy
Sigma-Aldrich	00922	Difluoroacetic acid for LC-MS LiChropur^™, ≥97.5% (GC)	381-73-7	1 mL	$52	2026-04-30	Buy
Sigma-Aldrich	00922	Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC)	381-73-7	10X1ML	$320	2026-04-30	Buy
Sigma-Aldrich	00922	Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC)	381-73-7	50ML	$1020	2026-04-30	Buy

Product number	Packaging	Price	Buy
142859	5g	$86.5	Buy
142859	25g	$210	Buy
00922	1 mL	$52	Buy
00922	10X1ML	$320	Buy
00922	50ML	$1020	Buy

Difluoroacetic acid Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light brown liquid

Uses

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.

Flammability and Explosibility

Non flammable

Synthesis

79-43-6

381-73-7

The following is the generic synthesis procedure employed in Examples 10 to 12: 2 g of dichloroacetic acid was added to an aqueous solution of potassium fluoride (KF) preheated to 120°C. The reaction system was kept continuously stirred at 120°C for 1 hour. Upon completion of the reaction, the system was cooled to room temperature and the aqueous solution was subsequently analyzed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and nuclear magnetic resonance fluorine spectroscopy (19F NMR). The specific operating conditions and corresponding results are detailed in the following table (III).

Purification Methods

Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]

References

[1] Patent: US2013/131375, 2013, A1. Location in patent: Paragraph 0116; 0117; 0118; 0119

Difluoroacetic acid synthesis

Synthesis of Difluoroacetic acid from Ethyl difluoroacetate and Trifluoroacetic acid

Difluoroacetic acid Preparation Products And Raw materials

Raw materials

CHLORODIFLUOROACETYL CHLORIDE Chlorodifluoroacetic acid METHYL CHLORODIFLUOROACETATE Dichloroacetic acid Formic acid

METHYL DIFLUOROACETATE Tetrafluoroethylene Methanol Ethyl difluoroacetate CHLOROFLUOROACETIC ACID

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Preparation Products

BROMODIFLUOROACETIC ACID TETRAFLUOROSUCCINIC ACID 2-Difluoromethyl-1H-benzoimidazole 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole 2-(DifluoroMethyl)-1-phenyl-4,5-dihydro-1H-iMidazole

3-Buten-2-one, 4-ethoxy-1,1-difluoro-, (3E)-

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Difluoroacetic acid Suppliers

Global( 386)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
CD Chemical Group Limited	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

Difluoroacetic Acid: Environmental Behavior & C-H Difluoromethylation
Difluoroacetic acid exists in CFC-contaminated groundwater and acts as a novel radical source for controllable heteroaromatic ....
Feb 9，2026

View Lastest Price from Difluoroacetic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	Difluoroacetic acid 381-73-7	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-03	Difluoroacetic acid 381-73-7	US $90.00-900.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2025-04-04	Difluoroacetic acid 381-73-7	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Difluoroacetic acid
381-73-7
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Difluoroacetic acid
381-73-7
US $90.00-900.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Difluoroacetic acid
381-73-7
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Difluoroacetic acid Spectrum

Difluoroacetic acid(381-73-7)MS Difluoroacetic acid(381-73-7)¹HNMR Difluoroacetic acid(381-73-7)¹³CNMR Difluoroacetic acid(381-73-7)IR1 Difluoroacetic acid(381-73-7)Raman

381-73-7(Difluoroacetic acid)Related Search:

Ethyl 2-(Chlorosulfonyl)acetate 2-Bromo-2,2-difluoroacetic acid ethyl ester Folic acid Trifluoroacetic acid Trifluoroacetic anhydride

DIFLUOROACETIC ACID ETHYL ESTER,ETHYL DIFLUOROACETIC ACID Fluroxypyr DIFLUOROACETIC ACID METHYL ESTER,α,2-Difluoroacetic acid methyl ester Ethyl trifluoroacetate Chlorodifluoroacetic acid ethyl ester

Sodium chlorodifluoroacetate Diethyl 2,2-difluoromalonate Citric acid Glycine Ascoric Acid

DIFLUOROACETIC ACID ANHYDRIDE TRIMETHYLSILYL TRIFLUOROACETATE THALLIUM(III) TRIFLUOROACETATE

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1,1-DIFLUOROACETIC ACID VITAS-BB TBB000649 DIFLUOROACETIC ACID Acetic acid, difluoro- difluoro-aceticaci Difluoroaceticacid98% Difluoroacetic acid, 98% 10ML Difluoroacetic acid, 98% 2.5ML 2,2-Difluoroethanoic acid Twotrifluoroacetic acid Aceticacid, 2,2-difluoro- Difluoroacetic acid, 97%+ Difluoroacetic Acid > ifluoroaceticaci DIFLUOROACETATE Difluoroaceticacid(DFA) 2,2-DIFLUOROACETIC ACID 381-73-7 7381-73-7 F2CHCO2H F2CHCOOH CHF2COOH C2H2F2O2 CARBOXYLIC ACID Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Fluorinated Building Blocks Synthetic Reagents Organic Acids Pharmaceutical Intermediates Small molecule Organic Fluorides Fluorinated Building Blocks Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Synthetic Organic Chemistry Chemical Synthesis Organic Acids Synthetic Reagents