ROLIPRAM
- CAS No.
- 61413-54-5
- Chemical Name:
- ROLIPRAM
- Synonyms
- 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;ROLIPRAM;SB 95952;ZK-62711;Roliprame;Rolipram >ROLIPRAM 98+%;(R,S)-Rolipram;Rolipram, >=97%;Rolipram Rolipram
- CBNumber:
- CB2703866
- Molecular Formula:
- C16H21NO3
- Molecular Weight:
- 275.34
- MDL Number:
- MFCD00270906
- MOL File:
- 61413-54-5.mol
- MSDS File:
- SDS
| Melting point | 127-133 °C |
|---|---|
| Boiling point | 418.29°C (rough estimate) |
| Density | 1.0677 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O: 0.2 mg/mL |
| form | solid |
| pka | 16.02±0.40(Predicted) |
| color | white to off-white |
| Merck | 14,8251 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| FDA UNII | K676NL63N7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-11 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UY5749237 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29337900 | |||||||||
| Toxicity | LD50 oral in mouse: > 300mg/kg | |||||||||
| NFPA 704 |
|
ROLIPRAM price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R6520 | Rolipram solid, ≥98% (HPLC) | 61413-54-5 | 10mg | $176 | 2024-03-01 | Buy |
| Sigma-Aldrich | 557330 | Rolipram | 61413-54-5 | 5mg | $230 | 2024-03-01 | Buy |
| TCI Chemical | R0110 | Rolipram >98.0%(HPLC) | 61413-54-5 | 50mg | $198 | 2024-03-01 | Buy |
| TCI Chemical | R0110 | Rolipram >98.0%(HPLC) | 61413-54-5 | 250mg | $686 | 2024-03-01 | Buy |
| Alfa Aesar | J67177 | Rolipram, 98% | 61413-54-5 | 5mg | $61.1 | 2023-06-20 | Buy |
ROLIPRAM Chemical Properties,Uses,Production
Description
Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.
Chemical Properties
Yellowish solid
Uses
(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.
Uses
Pharmacological tool for characterization of phosphodiesterase isoenzymes.
Uses
A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).
Uses
antipsychotic
Definition
ChEBI: Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.
General Description
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).
Biochem/physiol Actions
Cell permeable: yes
storage
Room temperature
References
1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837
ROLIPRAM Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
