Gonadorelin
- CAS No.
- 33515-09-2
- Chemical Name:
- Gonadorelin
- Synonyms
- LHRH;GONADOTROPIN-RELEASING HORMONE;GRH;Gonadoreline;PYR-HWSYGLRPG-NH2;PYR-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2;LUTEINIZING HORMONE-RELEASING HORMONE (LH-RH), HUMAN;LRF;LNRH;ZBTB7
- CBNumber:
- CB2706342
- Molecular Formula:
- C55H75N17O13
- Molecular Weight:
- 1182.31
- MDL Number:
- MFCD00167538
- MOL File:
- 33515-09-2.mol
| Product description | Number | Pack Size | Price |
| Gonadorelin European Pharmacopoeia (EP) Reference Standard | G0525000 | 5 mg | $254 |
| Gonadorelin | 1296803 | 6.53mg | $656 |
| Gonadorelin European Pharmacopoeia (EP) Reference Standard | G0525000 | g0525000 | $220 |
| Luteinizinghormonereleasinghormonehumanacetatesalt(LHRH) | A1147 | 1mg | $18 |
| Luteinizinghormonereleasinghormonehumanacetatesalt(LHRH) | A1147 | 5mg | $54 |
| More product size | |||
| Density | 1.54 |
|---|---|
| solubility | ≥118.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥28.7 mg/mL in H2O |
| pka | 9.82±0.15(Predicted) |
| InChIKey | XLXSAKCOAKORKW-AQJXLSMYSA-N |
| FDA UNII | 9O7312W37G |
| ATC code | H01CA01,V04CM01 |
Gonadorelin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G0525000 | Gonadorelin European Pharmacopoeia (EP) Reference Standard | 33515-09-2 | 5 mg | $254 | 2026-03-19 | Buy |
| Sigma-Aldrich | 1296803 | Gonadorelin | 33515-09-2 | 6.53mg | $656 | 2026-03-19 | Buy |
| Sigma-Aldrich | G0525000 | Gonadorelin European Pharmacopoeia (EP) Reference Standard | 33515-09-2 | g0525000 | $220 | 2024-03-01 | Buy |
| ApexBio Technology | A1147 | Luteinizinghormonereleasinghormonehumanacetatesalt(LHRH) | 33515-09-2 | 1mg | $18 | 2021-12-16 | Buy |
| ApexBio Technology | A1147 | Luteinizinghormonereleasinghormonehumanacetatesalt(LHRH) | 33515-09-2 | 5mg | $54 | 2021-12-16 | Buy |
Gonadorelin Chemical Properties,Uses,Production
Chemical Properties
Off-white freeze-dried powder. Soluble in water and saline.
Uses
Gonad-stimulating principle.
Uses
Gonadorein is a Gonadotropin-releasing hormone. Gonadorelin agonist treatment for men with locoregional prostate cancer may be associated with an increased risk of incident diabetes and ardiovascular disease.
Definition
ChEBI: Gonadorelin is a ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It has a role as a gonadotropin releasing hormone agonist. It is an oligopeptide and a peptide hormone.
brand name
Lutrepulse (Ferring Pharmaceuticals).
Biological Activity
luteinizing hormone releasing hormone human acetate salt (lhrh) is a selective acitivator of mmp-2 and mmp-9 [1, 2].luteinizing hormone-releasing hormone (lhrh), also known as gonadotropin-releasing hormone (gnrh) is a trophic peptide hormone which secreted by gnrh neurons and plays an important role in the release of follicle-stimulating hormone (fsh) and luteinizing hormone (lh) from the anterior pituitary [3].mmp-2 (matrix metalloproteinase-2) and mmp-9 (matrix metalloproteinase-9) belong to the mmp family that play an important role in the breakdown of extracellular matrix (ecm) in normal physiological processes, for example, embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis [2].when tested with ishikawa and ecc-1 cell lines, lhrh resulted in the increase of mmp-9 expression which induced cell invasion and it was also showed that gpr101 mediated the lhrh activity and cooperated to function in the metastatic potential of endometrial cancer cells [1]. in human decidual endometrial stromal cells, lhrh with its receptor induced the activation of mmp-2 and mmp-9 [2].
Side effects
If you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) to gonadorelin, seek emergency medical attention.
Other less serious side effects may also occur. Notify your doctor if you experience: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or skin rash.
Veterinary Drugs and Treatments
Gonadorelin is indicated (approved) for the treatment of ovarian
follicular cysts in dairy cattle. Additionally, gonadorelin has been
used in cattle to reduce the time interval from calving to first ovulation
and to increase the number of ovulations within the first 3
months after calving. This may be particularly important in increasing
fertility in cows with retained placenta.
In dogs, gonadorelin has been used experimentally to help diagnose
reproductive disorders or to identify intact animals versus castrated
ones by maximally stimulating FSH and LH production. It
has also been used experimentally in dogs to induce estrus through
pulsatile dosing. While apparently effective,
specialized administration
equipment is required for this method.
Gonadorelin has been used in cats as an alternate therapy to FSH
or hCG to induce estrus in cats with prolonged anestrus.
In Europe, a synthetic analogue buserelin has been used in horses
to stimulate cyclic estrus. Its efficacy
rates poorly when compared
to an artificial light program, however.
In human medicine, gonadorelin has been used for the diagnosis
of hypothalamic-pituitary dysfunction,
cryptorchidism, and depression
secondary to prolonged severe stress.
Description
Lutenizing Hormone Releasing Hormone Human Synthetic is a single, non-glycosylated, polypeptide chain containing 10 amino acids and having a molecular mass of 1182.2 Dalton. The molecular formula is C55H75N17O13.C2H4O2. The CAS Number is 71447-49-9.
Background
Gonadotropin-releasing hormone 1 (GNRH1), also known as Luteinising-hormone releasing hormone (LHRH), is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GNRH1 is synthesized and released by the hypothalamus.
At the pituitary, GNRH1 stimulates the synthesis and secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These processes are controlled by the size and frequency of GNRH1 pulses, as well as by feedback from androgens and estrogens. Low requency GNRH1 pulses lead to FSH release, whereas high frequency GNRH1 pulses stimulate LH release.
There are differences in GNRH1 secretion between males and females. In males, GNRH1 is secreted in pulses at a constant frequency, but in females the frequency of the pulses varies during the menstrual cycle and there is a large surge of GNRH1 just before ovulation.
GNRH1 secretion is pulsatile in all vertebrates, and is necessary for correct reproductive function. Thus, a single hormone, GNRH1, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male.
References
[1]. cho-clark, m., et al., gnrh-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion. mol cell endocrinol, 2015.
[2]. wu, h.m., et al., gonadotropin-releasing hormone type ii (gnrh-ii) agonist regulates the motility of human decidual endometrial stromal cells: possible effect on embryo implantation and pregnancy. biol reprod, 2015. 92(4): p. 98.
[3]. garnick, m.b. and m. campion, abarelix depot, a gnrh antagonist, v lhrh superagonists in prostate cancer: differential effects on follicle-stimulating hormone. abarelix depot study group. mol urol, 2000. 4(3): p. 275-7.
Gonadorelin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Hebei Xunou new energy Technology Co., LTD | +86-17531957005; +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
| TsurgeX Pharmaceutical Technology Co., Ltd. | +8613393959797 | master@tsurgex.com | China | 44 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 | saixinkeji@aliyun.com | China | 86 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| .GZ HONESTCHEM CO.,LTD | +8615013270415 | honestchemical@foxmail.com | China | 300 | 58 |
View Lastest Price from Gonadorelin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-27 | Gonadoreline | US $1.00 / kit | 1kit | 99.9% | 200 | .GZ HONESTCHEM CO.,LTD | |
 |
2026-04-24 | Gonadorelin Acetate
33515-09-2
|
US $1.00 / Piece | 1Piece | 99% | 10000 | HR Biotechnology Co.,Ltd | |
 |
2026-03-26 | Gonadorelin 2mg/5mg/10mg
33515-09-2
|
US $60.00-40.00 / kit | 1kit | 99% | 10000kits | Shenzhen Aoxi Technology Co., Ltd. |
-
- Gonadoreline
- US $1.00 / kit
- 99.9%
- .GZ HONESTCHEM CO.,LTD
-
- Gonadorelin Acetate
33515-09-2
- US $1.00 / Piece
- 99%
- HR Biotechnology Co.,Ltd
-
- Gonadorelin 2mg/5mg/10mg
33515-09-2
- US $60.00-40.00 / kit
- 99%
- Shenzhen Aoxi Technology Co., Ltd.
33515-09-2(Gonadorelin)Related Search:
1of4
