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Polyethylene-polypropylene glycol

CAS No.
9003-11-6
Chemical Name:
Polyethylene-polypropylene glycol
Synonyms
Poloxamer;PLURONIC F-127;PLURONIC;POLOXAMER 407;POLOXAMER 188;Polyether;P188;PEG-PPG-PEG;PLURONIC F-68;poloxalene
CBNumber:
CB2709101
Molecular Formula:
(C3H6O.C2H4O)x
Molecular Weight:
102.1317
MDL Number:
MFCD00082049
MOL File:
9003-11-6.mol
MSDS File:
SDS
Last updated:2024-01-19 14:22:57

Polyethylene-polypropylene glycol Properties

Melting point 57-61 °C
Boiling point >200 °C(lit.)
Density 1.095 g/mL at 25 °C
vapor density >1 (vs air)
vapor pressure <0.3 mm Hg ( 20 °C)
refractive index n20/D 1.466
Flash point >230 °F
storage temp. 2-8°C
solubility H2O: at <70 °Csoluble
form solution
color APHA: ≤120, 50/50 in CH3OH
PH Range 5.0 - 7.5
PH 5.0-7.5 (100g/L in H2O)
Water Solubility Miscible with water.
λmax λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck 13,7644
LogP -1.293 (est)
FDA 21 CFR 184.1666; 556.517; 558.464; 573.760; 582.1666; 582.4666; 178.3570; 310.545; 558.4
Substances Added to Food (formerly EAFUS) ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER
EWG's Food Scores 2
FDA UNII PEG/PPG-35/9 COPOLYMER (1AZW43116L)
PEG/PPG-240/60 COPOLYMER (199SZS8E2Q)
PEG/PPG-30/160 COPOLYMER (68T8I45V23)
PEG/PPG-105/5 COPOLYMER (52901V8XAR)
PEG/PPG-18/4 COPOLYMER (66UUC8WX0D)
EPA Substance Registry System Poloxalene (9003-11-6)
Cosmetics Info Poloxamer 407

SAFETY

Risk and Safety Statements

Hazard statements  H412
Precautionary statements  P273-P501
Hazard Codes  T
Risk Statements  21-23/24/25-25-36/37/38
Safety Statements  23-24/25-45-36/37/39-26
WGK Germany  3
RTECS  TP6164333
TSCA  Yes
HS Code  39059100
Toxicity LD50 oral in rabbit: 35gm/kg

Polyethylene-polypropylene glycol price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 438200 Poly(ethylene glycol-ran-propylene glycol) average Mn ~12,000 9003-11-6 250ML $56.3 2024-03-01 Buy
Sigma-Aldrich 438200 Poly(ethylene glycol-ran-propylene glycol) average Mn ~12,000 9003-11-6 1L $98.4 2024-03-01 Buy
Sigma-Aldrich 1.37097 Poloxamer 188 EMPROVE EXPERT cell culture optimized (stabilizedwith70ppmBHT) 9003-11-6 1kg $430 2024-03-01 Buy
Sigma-Aldrich 1.37097 Poloxamer 188 EMPROVE EXPERT cell culture optimized (stabilizedwith70ppmBHT) 9003-11-6 10Kg $2960 2024-03-01 Buy
Sigma-Aldrich 1.37097 Poloxamer 188 EMPROVE EXPERT cell culture optimized (stabilizedwith70ppmBHT) 9003-11-6 25kg $6850 2024-03-01 Buy
Product number Packaging Price Buy
438200 250ML $56.3 Buy
438200 1L $98.4 Buy
1.37097 1kg $430 Buy
1.37097 10Kg $2960 Buy
1.37097 25kg $6850 Buy

Polyethylene-polypropylene glycol Chemical Properties,Uses,Production

Chemical Properties

Polyethylene-polypropylene glycol generally occur as white, waxy, free-flowing prilled granules, or as cast solids. They are practically odorless and tasteless. At room temperature, poloxamer 124 occurs as a colorless liquid.

Originator

Polykol ,Upjohn, US ,1958

Uses

Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.

Uses

Polyethylene-polypropylene glycol is a liquid surfactant polymer.

Uses

pyrethroid-based pesticide for use in mosquito control

Definition

ChEBI: Poloxamer is an epoxide.

Production Methods

Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol. Ethylene oxide is then added to form the block copolymer.

Manufacturing Process

(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide. The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved. Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380. The product was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered. The final product was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.
(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide. 105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A). The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.

brand name

Lutrol F (BASF); Pluracare (BASF); Pluronic (BASF).

Therapeutic Function

Pharmaceutic aid (surfactant)

General Description

Pluronic? L-81 is a lipoprotein secretion inhibitor.

Pharmaceutical Applications

Polyethylene-polypropylene glycol is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the Polyethylene-polypropylene glycol is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;
Polyethylene-polypropylene glycol is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.

Biological Activity

Polyethylene-polypropylene glycol(Poloxamer 188) is a copolymer surfactant. Poloxamer 188 exhibits antithrombotic, anti-inflammatory and cytoprotective activities in various tissue injury models. It can be used to treat sickle cell disease in children and adults. It has also been shown to be protective against ischaemic injury, cardiomyopathy and cerebral haemorrhage.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Polyethylene-polypropylene glycol is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.Polyethylene-polypropylene glycol is not metabolized in the body.
Animal toxicity studies, with dogs and rabbits, have shown Polyethylene-polypropylene glycol to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.
In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.
No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.
(mouse, IV): 1 g/kg
(mouse, oral): 15 g/kg
(mouse, SC): 5.5 g/kg
(rat, IV): 7.5 g/kg
(rat, oral): 9.4 g/kg

storage

Polyethylene-polypropylene glycol is stable materials. Aqueous solutions are stable in the presence of acids, alkalis, and metal ions. However, aqueous solutions support mold growth.
The bulk material should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Depending on the relative concentrations, poloxamer 188 is incompatible with phenols and parabens.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV injections; inhalations, ophthalmic preparations; oral powders, solutions, suspensions, and syrups; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Global( 544)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850 +86-13986145403 info@fortunachem.com China 5981 58
Shaanxi Dideu Medichem Co. Ltd
18192627656 1012@dideu.com China 3911 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 4685 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682 bruce@xrdchem.cn CHINA 566 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60

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Polyethylene-polypropylene glycol pictures 2024-01-11 Polyethylene-polypropylene glycol
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