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2-Bromo-4'-methoxyacetophenone

2-Bromo-4'-methoxyacetophenone structure

CAS No.: 2632-13-5

Chemical Name:: 2-Bromo-4'-methoxyacetophenone

Synonyms: 2-BROMO-1-(4-METHOXYPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-METHOXYPHENYL)ETHANONE;PTP Inhibitor II;4-methoxy phenecyl bromide;PTP inhibitor 1;AKOS BBS-00000817;2-Bromo-4-methoxy;TIMTEC-BB SBB007777;2-Bromo-4'-methoxyac;4-METHOXYPHENACYL BR

CBNumber:: CB2715762

Molecular Formula:: C9H9BrO2

Molecular Weight:: 229.07

MDL Number:: MFCD00000201

MOL File:: 2632-13-5.mol

MSDS File:: SDS

Last updated:2023-10-10 14:04:25

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2-Bromo-4'-methoxyacetophenone Properties

Melting point	69-71 °C(lit.)
Boiling point	215.8°C (rough estimate)
Density	1.4921 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Crystals or Crystalline Powder
color	Off-white to light brown
Water Solubility	It is soluble in DMSO, water (partly miscible), most organic solvents, and methanol.
BRN	743112
InChI	InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
InChIKey	XQJAHBHCLXUGEP-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(OC)C=C1)CBr
CAS DataBase Reference	2632-13-5(CAS DataBase Reference)
FDA UNII	PV5M69J53H
NIST Chemistry Reference	Ethanone, 2-bromo-1-(4-methoxyphenyl)-(2632-13-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H314-H335

Precautionary statements

P260-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338

Hazard Codes

C,Xi

Risk Statements

34-36/37-36/37/38

Safety Statements

26-27-28-36/37/39-45-37/39

RIDADR

UN 3261 8/PG 2

WGK Germany

8-9-19-21

Hazard Note

Corrosive

HazardClass

PackingGroup

III

HS Code

29147090

NFPA 704

	1
3		0

2-Bromo-4'-methoxyacetophenone price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	115665	2-Bromo-4′-methoxyacetophenone 97%	2632-13-5	5g	$83.8	2024-03-01	Buy
Sigma-Aldrich	115665	2-Bromo-4′-methoxyacetophenone 97%	2632-13-5	25g	$399	2024-03-01	Buy
TCI Chemical	M1004	4'-Methoxyphenacyl Bromide >98.0%(GC)	2632-13-5	5g	$30	2024-03-01	Buy
TCI Chemical	M1004	4'-Methoxyphenacyl Bromide >98.0%(GC)	2632-13-5	25g	$85	2024-03-01	Buy
Alfa Aesar	A13415	2-Bromo-4'-methoxyacetophenone, 98%	2632-13-5	5g	$33.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
115665	5g	$83.8	Buy
115665	25g	$399	Buy
M1004	5g	$30	Buy
M1004	25g	$85	Buy
A13415	5g	$33.65	Buy

2-Bromo-4'-methoxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

off-white to light brown crystals or

Uses

2-Bromo-4'-methoxyacetophenone, is used as a cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.

Uses

2-Bromo-4'-methoxyacetophenone is a α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

Preparation

Obtained by reaction of N-bromosuccinimide (NBS) with 4-methoxyacetophenone in the presence of trimethylsilyl trifluoromethanesulfonate (TMS-OTf) in acetonitrile at r.t. for 24 h (87%).

Biological Activity

ki: 128 μmptp inhibitor ii is a protein tyrosine phosphatase (ptp) inhibitor.protein tyrosine phosphatases (ptps) are reported to be involved in the etiology of diabetes mellitus, neural diseases such as alzheimer and parkinson diseases, regulation of allergy and inflammation, or ptps are even regarded to be responsible for the pathogens.

in vitro

in a previous study, it was found that all of the previously reported ptp inhibitors contained a negatively charged, nonhydrolyzable py mimetic as the core structure, such as malonates, aryl carboxylates, phosphonates, or cinnamates. the poor membrane permeability of these inhibitors might compromise their potential development. it was reported that several α-bromoacetophenone derivatives, such as ptp inhibitor ii, could act as fairly potent ptp inhibitors, by covalently alkylating the conserved catalytic cysteine in the ptp active site. since ptp inhibitor ii is neutral, it could readily diffuse into human b cells and inhibit the intracellular ptps. the sar study was performed with the catalytic domain of phosphatase shp-1, and ti was found that ptp inhibitor ii showed time-dependent inactivation of shp-1, consistent with the mechanism. furthermore, the potency of ptp inhibitor ii was described by an equilibrium constant ki, representing the dissociation constant of the noncovalent enzyme–inhibitor complex. ptp inhibitor ii bound with lower affinity than ptp inhibitor i with ki values of 128 μm [1].

References

[1] p. heneberg. use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. current medicinal chemistry 16(6), 706-733 (2009).

2-Bromo-4'-methoxyacetophenone Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Hexane Sodium chloride SILICA Ethyl acetate

Sodium bicarbonate Government regulation Acetic acid Magnesium sulfate

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Preparation Products

Raloxifene 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE 2-(4-METHOXYBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE 4-METHOXYPHENETHYL BROMIDE 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol

Thiazole, 4-(4-methoxyphenyl)-2-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]- 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-methoxyphenyl)-2-oxoethyl]- METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-1-(4-METHOXYPHENYL)-1-ETHANONE

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2-Bromo-4'-methoxyacetophenone Suppliers

Global( 416)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 2-Bromo-4'-methoxyacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-10-10	2-Bromopropionyl bromide 2632-13-5	US $40.00-10.00 / kg	1kg	0.99	15 tons	Hebei Yanxi Chemical Co., Ltd.
2023-09-26	2-Bromopropionyl bromide 2632-13-5	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-26	2-Bromo-4'-methoxyacetophenone 2632-13-5	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

2-Bromopropionyl bromide
2632-13-5
US $40.00-10.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

2-Bromopropionyl bromide
2632-13-5
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2-Bromo-4'-methoxyacetophenone
2632-13-5
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2-Bromo-4'-methoxyacetophenone Spectrum

2-Bromo-4'-methoxyacetophenone(2632-13-5)MS 2-Bromo-4'-methoxyacetophenone(2632-13-5)¹HNMR 2-Bromo-4'-methoxyacetophenone(2632-13-5)¹³CNMR 2-Bromo-4'-methoxyacetophenone(2632-13-5)IR1 2-Bromo-4'-methoxyacetophenone(2632-13-5)IR2

2632-13-5(2-Bromo-4'-methoxyacetophenone)Related Search:

3,4-Dimethoxyacetophenone Acetophenone Ethidium bromide 4'-Bromoacetophenone 3-Nitroacetophenone

Chalcone Sodium bromate 3'-Bromoacetophenone Clidinium bromide L-PICEIN

4'-Methylacetophenone 3',5'-Dimethoxyacetophenone 2-Methoxyethanol 3-Bromoanisole 4'-Methoxyacetophenone

2'-Methoxyacetophenone 4-Nitroacetophenone 4'-Hydroxyacetophenone

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1-(2-bromo-4-methoxyphenyl)ethanone P-Methoxy-α-bromoacetophenone ω-Bromo-4-methoxyacetophenone, 4-Methoxyphenacyl bromide 2-(4-Methoxyphenyl)-2-oxoethyl bromid 1-(4-Mehtoxyphenyl)-2-bromoethanone 1-(Bromoacetyl)-4-methoxybenzene 4'-Methoxy-α-bromoacetophenone 2-Bromo-4'-methoxyacetophenone,98% 2-Bromo-4′-methoxyacetophenone,ω-Bromo-4-methoxyacetophenone, 4-Methoxyphenacyl bromide 2-Bromo-4'-methoxyac 2-Bromo-4'-methoxyacetophenone, 2-Bromo-1-(4-methoxyphenyl)ethan-1-one, 4-(Bromoacetyl)anisole 4-Methoxyphenacyl Bromide 98% 2-BroMo-1-[4-(Methyloxy)phenyl] ethanone alpha-Bromo-4'-methoxyacetophenone 4-(Bromoacetyl)anisole 2-BroMo-4'-Methoxyacetophenone 97% 4-Methoxyphenacylbromide,98% ALPHA-BROMO-4'-METHOXYACETOPHENONE ALPHA-BROMO-4-METHOXYACETOPHENONE AKOS BBS-00000817 Bromomethyl 4-methoxyphenyl ketone 4-(BROMOACETYL)ANISOLE 4-METHOXYPHENACYL BR 4'-METHOXYPHENACYL BROMIDE 4-METHOXYPHENACYL BROMIDE A-BROMO-P-METHOXYACETOPHENONE 2-BROMO-4-METHOXY ACETOPHENONE TIMTEC-BB SBB007777 OMEGA-BROMO-P-METHOXY ACETOPHENONE OMEGA-BROMO-4-METHOXYACETOPHENONE P-METHOXYPHENACYL BROMIDE PROTEIN TYROSINE PHOSPHATASE INHIBITOR II W-BROMO-4-METHOXY-ACETOPHENONE 2-(4-Methoxyphenyl)-2-oxoethyl bromide 2-Bromo-1-(4-methoxyphenyl)-1-ethanone Ethanone, 2-bromo-1-(4-methoxyphenyl)- 2-Bromo-4-methoxy ω-bromo-4-methoxyacetophenone 2-Bromo-4'-methoxyacetophenone, Pract. 2-Bromo-4'-methoxyacetophenone, 2-Bromo-1-(4-methoxyphenyl)ethan-1-one P-Methoxy-A-Bromoacetophenone 2-BROMO-4''-METHOXYACETOPHENONE (4-METHOXYPHENACYL BROMIDE) 2-bromo-1-(4-methoxyphenyl)-ethanon 2-Bromo-p-methoxyacetophenone 4'-Methoxy-2-bromoacetophenone a-Bromo-4'-methoxyacetophenone Acetophenone, 2-bromo-4'-methoxy- alpha-Bromo-p-methoxyacetophenone Bromomethyl p-anisyl ketone w-Bromo-p-methoxyacetophenone 2-Bromo-4'-Methoxyacetophenone 4'-Methoxyphenacyl Bromide 2-Bromo-1-(4-Methoxyphenyl)ethan-1-one p-Methoxy-alpha-Chloroacetophenone Bromo Methoxy Acetophenone Para Methoxy Phenacyl Bromide 2-Bromo-4'-methoxyacetophenone, 98%, reagent grade 4'-MethoxyphenacylBromide> PTP inhibitor 1 α-Bromo-4-methoxyacetophenone Raloxifene Impurity 12