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Kanamycin sulfate

Description Reference
Kanamycin sulfate
Kanamycin sulfate structure
CAS No.
25389-94-0
Chemical Name:
Kanamycin sulfate
Synonyms
kano;KAMYCIN;Kantrex;Kantrim;cantrex;kamynex;kanaqua;kanasig;kanicin;kantrox
CBNumber:
CB2722315
Molecular Formula:
C18H38N4O15S
Formula Weight:
582.58
MOL File:
25389-94-0.mol

Kanamycin sulfate Properties

Melting point:
250°C
alpha 
+112~+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)
Density 
1.3619 (rough estimate)
refractive index 
117.5 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
form 
powder
color 
white to off-white
PH Range
6.5 - 8.5 (1% solution)
Water Solubility 
Soluble in water at 10mg/ml
Merck 
14,5281
InChIKey
OOYGSFOGFJDDHP-KMCOLRRFSA-N
FDA UNII
J80EX28SMQ
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H303-H317-H334-H360
Precautionary statements  P201-P308+P313-P280-P261-P284-P405-P501a
Hazard Codes  T
Risk Statements  61
Safety Statements  22-24/25-45-53
WGK Germany  3
RTECS  NZ3225030
HS Code  29419020
Toxicity LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)

Kanamycin sulfate price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 420311 Kanamycin Sulfate, Streptomyces kanamyceticus - CAS 25389-94-0 - Calbiochem An aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms. 25389-94-0 5 g $69.37 2021-03-22 Buy
Sigma-Aldrich 420311 Kanamycin sulfate 25389-94-0 5gm $69.8 2020-08-18 Buy
Sigma-Aldrich 420411 Kanamycin Sulfate, Streptomyces kanamyceticus, Cell Culture-Tested - CAS 25389-94-0 - Calbiochem 25389-94-0 5 g $81.77 2021-03-22 Buy
Sigma-Aldrich 420311 Kanamycin Sulfate, Streptomyces kanamyceticus - CAS 25389-94-0 - Calbiochem An aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms. 25389-94-0 25 g $307.1 2021-03-22 Buy
Sigma-Aldrich 420411 Kanamycin Sulfate, Streptomyces kanamyceticus, Cell Culture-Tested - CAS 25389-94-0 - Calbiochem 25389-94-0 25 g $361.67 2021-03-22 Buy

Kanamycin sulfate Chemical Properties,Uses,Production

Description

It has been well known as desirable antibiotics, which shows an obvious curative effect on serious infections caused by gram-negative bacteria such as Escherichia coil, Klebsiella, Proteus, Pneumonia, Enterobacter aerogenes and Shigella. Clinically, this substance is mainly used for infections caused by sensitive bacteria including pulmonary infection, urinary tract infection, biliary tract infection, sepsis, and abdominal cavity infection. For example, the effective antibacterial activity of kanamycin sulfate has been demonstrated by the treatment of acute gonorrheal urethritis in men, showing that a single parenterally administered dose of 2 mg of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis.1 Moreover, kanamycin sulfate was found to be a valuable drug in the treatment of serious infections in infants and children through an analysis of 140 cases treated during a two-year period.2

Reference

  1. JE Fischnaller; AH Pedersen; AR Ronald; P Bonin; Tronca, E., Kanamycin sulfate in the treatment of acute gonorrheal urethritis in men. The Journal of the American Medical Association 1968, 203, 909-912.
  2. MD Yow; Tengg, N., The use of kanamycin sulfate as a therapeutic agent for infants and children. An analysis of 140 cases treated during a two-year period. Journal of Pediatrics 1961, 58, 538-547.

Chemical Properties

Off-white powder

Originator

Kantrex,Bristol,US,1958

Uses

Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

Uses

Kanamycin sulfate is an antibacterial agent similar to neomycin.

Definition

A broadspectrum antibiotic.

Manufacturing Process

As described in US Patent 2,931,798, Streptomyces kanamyceticus (K2-J) was first cultured in shake flasks in the following media: (a) 0.75% meat extract, 0.75% peptone, 0.3% NaCl, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol; or (b) 2.0% soybean meal, 0.05% KCl, 0.05% MgSO4 · 7H2O, 0.5% NaCl, 0.2% NaNO3, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol. The initial pH of all media was adjusted to 7.0. After 24 to 48 hours shaking in some cases the pH decreased to about 6.0 to 6.8, but from 72 to 120 hours the pH rose and became 7.5 to 8.6. The production of kanamycin was apparent after 48 hours and, depending on the media; the maximum production was found after 72 to 120 hours.
The yield was highest with starch or dextrin, intermediate and about the same with sucrose, glucose, maltose and lactose and poorest with glycerol. Kanamycin was produced by media containing soybean meal, peanut meal, cottonseed meal, corn steep liquor, peptone, yeast extract or meat extract, with or without sodium nitrate. Commercially available soybean meal was recognized to be one of the best nitrogen sources. The addition of corn steep liquor, peptone, yeast extract or nitrate to the soybean meal promoted the production of kanamycin.
The brownish white kanamycin (5 g) was dissolved in 50 ml of 60% aqueous methanol, insoluble material was removed and to the filtrate 40 ml of 60% aqueous methanol containing 2,000 mg of ammonium sulfate was added, and the precipitated kanamycin sulfate was collected, washed with 50 ml of 80% aqueous methanol, and dried. Thus, 4.5 g of kanamycin sulfate was obtained as a light brownish powder.

brand name

Klebcil (King).

Therapeutic Function

Antibacterial

Kanamycin sulfate Preparation Products And Raw materials

Raw materials

Preparation Products


Kanamycin sulfate Suppliers

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View Lastest Price from Kanamycin sulfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-27 Kanamycin sulfate
25389-94-0
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-21 Kanamycin sulfate
25389-94-0
US $1.00-50.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-10-20 Kanamycin sulfate
25389-94-0
US $95.00-79.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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