ODQ
- CAS No.
- 41443-28-1
- Chemical Name:
- ODQ
- Synonyms
- ODQ;ODQ,98%;ODQ inhibitor;ODQ - CAS 41443-28-1 - Calbiochem;[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one>ODQ1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE[ODQ]
- CBNumber:
- CB2730905
- Molecular Formula:
- C9H5N3O2
- Molecular Weight:
- 187.15
- MDL Number:
- MFCD00792620
- MOL File:
- 41443-28-1.mol
- MSDS File:
- SDS
| Melting point | 160-170 °C |
|---|---|
| Boiling point | 321.89°C (rough estimate) |
| Density | 1.3753 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| RTECS | RO0913150 |
| storage temp. | 2-8°C |
| solubility | ethanol: 1.2 mg/mL |
| form | powder |
| pka | 0.94±0.20(Predicted) |
| color | pale yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 41443-28-1(CAS DataBase Reference) |
| FDA UNII | S57V2NMV38 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
ODQ price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O3636 | 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one powder | 41443-28-1 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | 495320 | ODQ | 41443-28-1 | 10mg | $230 | 2024-03-01 | Buy |
| TCI Chemical | O0400 | 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one >95.0%(GC) | 41443-28-1 | 25mg | $162 | 2024-03-01 | Buy |
| Alfa Aesar | J62250 | 1H-[1,2,4]Oxadiazolo[4,3-a]-quinoxalin-1-one, 98+% | 41443-28-1 | 10mg | $96.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62250 | 1H-[1,2,4]Oxadiazolo[4,3-a]-quinoxalin-1-one, 98+% | 41443-28-1 | 50mg | $323.65 | 2024-03-01 | Buy |
ODQ Chemical Properties,Uses,Production
Description
ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC),?IC50?= 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2?ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1?ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
Chemical Properties
ODQ is off-white to yellow powder
Uses
ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor.
Uses
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.
Definition
ChEBI: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one is a member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group. It has a role as an EC 4.6.1.2 (guanylate cyclase) inhibitor.
Biological Activity
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.
Biochem/physiol Actions
H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.
storage
+4°C
References
1) Garthwaite?et al.?(1995),?Potent and Selective Inhibition of Nitric Oxide-sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; Mol. Pharmacol.?48?184 2) Schrammel?et al.?(1996),?Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase; Mol. Pharmacol.?50?1 3) Estevez?et al.?(1998),?Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor; J. Neurosci.?18?3708 4) Vandecasteele?et al.?(1998),?Role of the NO-cGMP in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes; J. Physiol.?506?653 5) Martins-Pinge?et al.?(1999),?Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats;?Hypertension?34?748
ODQ Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |