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Brompheniramine hydrogen maleate

Brompheniramine hydrogen maleate
Brompheniramine hydrogen maleate structure
CAS No.
980-71-2
Chemical Name:
Brompheniramine hydrogen maleate
Synonyms
dimegan;dimetane;dimotane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate;BROMPHENIRAMINE MALEATE
CBNumber:
CB2736194
Molecular Formula:
C20H23BrN2O4
Formula Weight:
435.31
MOL File:
980-71-2.mol

Brompheniramine hydrogen maleate Properties

Melting point:
134-135°C
Flash point:
9℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form 
neat
λmax
261nm(lit.)
Merck 
14,1443
InChIKey
SRGKFVAASLQVBO-BTJKTKAUSA-N
CAS DataBase Reference
980-71-2(CAS DataBase Reference)
FDA 21 CFR
341.12
EWG's Food Scores
1
FDA UNII
IXA7C9ZN03
EPA Substance Registry System
2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H225-H301+H311+H331-H370
Precautionary statements  P264-P270-P301+P312a-P330-P501a-P301+P312+P330-P210-P260-P280-P301+P310-P311
Hazard Codes  Xn,Xi,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS  US4025000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  38220090

Brompheniramine hydrogen maleate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B-043 Brompheniramine maleate solution 980-71-2 043-1ml $38.2 2020-08-18 Buy
Sigma-Aldrich B-043 Brompheniramine maleate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 980-71-2 1 mL $39.4 2021-03-22 Buy
Sigma-Aldrich 1078008 (±)-Brompheniramine maleate salt 980-71-2 125mg $297 2021-03-22 Buy
TCI Chemical B5167 Brompheniramine Maleate >98.0%(HPLC)(T) 980-71-2 25g $93 2021-03-22 Buy
Alfa Aesar J63922 Brompheniramine maleate 980-71-2 25mg $77.3 2021-03-22 Buy

Brompheniramine hydrogen maleate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Dimetane,Robins,US,1957

Uses

This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.

Uses

Antihistaminic;H1 Antagonist

Definition

ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.

Manufacturing Process

Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.

brand name

Dimetane (Wyeth).

Therapeutic Function

Antihistaminic

General Description

Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.

Side effects

The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.

Brompheniramine hydrogen maleate Preparation Products And Raw materials

Raw materials

Preparation Products


Brompheniramine hydrogen maleate Suppliers

Global( 166)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
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sales@coreychem.com CHINA 29954 58
Chongqing Chemdad Co., Ltd
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CONIER CHEM AND PHARMA LIMITED
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Shaanxi Dideu Medichem Co. Ltd
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029-88380327 1010@dideu.com CHINA 3993 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Zhengzhou Alfa Chemical Co.,Ltd
+8613343822234 +86-0371-55052911
sales5@alfachem.cn;sales9@alfachem.cn;sale1@alfachem.cn China 11816 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58

View Lastest Price from Brompheniramine hydrogen maleate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Brompheniramine hydrogen maleate
980-71-2
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-07-13 Brompheniramine hydrogen maleate
980-71-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 Brompheniramine hydrogen maleate
980-71-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Brompheniramine hydrogen maleate Spectrum


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