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Ferrous fumarate

Uses
Ferrous fumarate
Ferrous fumarate structure
CAS No.
141-01-5
Chemical Name:
Ferrous fumarate
Synonyms
firon;fumar;ircon;galfer;cpiron;ferrone;fumafer;fumar-f;hemoton;palafer
CBNumber:
CB2739933
Molecular Formula:
C4H2FeO4
Formula Weight:
169.9
MOL File:
141-01-5.mol

Ferrous fumarate Properties

Melting point:
>280°C
Density 
2.435
solubility 
Slightly soluble in water, very slightly soluble in ethanol (96 per cent).
form 
solid
Water Solubility 
Soluble in water (0.14 g/100 ml at 25°C).
Merck 
14,4046
Stability:
Stability
InChIKey
PMVSDNDAUGGCCE-TYYBGVCCSA-L
FDA 21 CFR
184.1307d; 310.545
Substances Added to Food (formerly EAFUS)
FERROUS FUMARATE
SCOGS (Select Committee on GRAS Substances)
Ferrous fumarate
CAS DataBase Reference
141-01-5(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
R5L488RY0Q
NCI Drug Dictionary
ferrous fumarate
EPA Substance Registry System
2-Butenedioic acid (2E)-, iron(2+) salt (1:1) (141-01-5)
SAFETY
  • Risk and Safety Statements
Risk Statements  36/37/38
Safety Statements  22-36/37/39-24/25
WGK Germany  2
RTECS  LT1950000
TSCA  Yes
HS Code  29171900
Toxicity LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum)

Ferrous fumarate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F5381 Iron(II) fumarate 97% 141-01-5 500g $83.7 2021-03-22 Buy
Sigma-Aldrich PHR1482 Ferrous fumarate Pharmaceutical Secondary Standard; Certified Reference Material 141-01-5 1g $129 2021-03-22 Buy
Alfa Aesar B23956 Iron(II) fumarate, 94% 141-01-5 250g $41.8 2021-03-22 Buy
Alfa Aesar B23956 Iron(II) fumarate, 94% 141-01-5 1000g $116 2021-03-22 Buy

Ferrous fumarate Chemical Properties,Uses,Production

Uses

Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.

Description

Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.

Chemical Properties

brown to reddish-brown powder

Chemical Properties

§184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.

Originator

Toleron,Mallinckrodt Inc.,US,1957

Uses

Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency.

Uses

Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks.

Definition

Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubl

Manufacturing Process

Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found.

Therapeutic Function

Hematinic

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID.

References

Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.
Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.

Ferrous fumarate Preparation Products And Raw materials

Raw materials

Preparation Products


Ferrous fumarate Suppliers

Global( 299)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Jiangsu Kolod Food Ingredients Co.,Ltd.
18805133257 +86-518-85110578 18805133257
+86-518-85110578 sales3257@jskolod.com CHINA 125 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5361 58

View Lastest Price from Ferrous fumarate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-14 Ferrous fumarate
141-01-5
US $198.00 / Kg/Bag 25Kg/Bag 99% 2000T Baoji Guokang Healthchem co.,ltd
2021-08-06 Ferrous fumarate USP/EP/BP
141-01-5
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
2021-07-13 Ferrous fumarate
141-01-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Ferrous fumarate Spectrum


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