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Taurine

Description History Medicinal effect Preparation References
Taurine
Taurine structure
CAS No.
107-35-7
Chemical Name:
Taurine
Synonyms
TATU;O-Due;TURIN;Taufon;Taukard;TAURINE;tauphon;NSC 32428;FEMA 3813;nci-c60606
CBNumber:
CB2742654
Molecular Formula:
C2H7NO3S
Formula Weight:
125.15
MOL File:
107-35-7.mol

Taurine Properties

Melting point:
>300 °C(lit.)
Density 
1.00 g/mL at 20 °C
refractive index 
1.5130 (estimate)
FEMA 
3813 | TAURINE
storage temp. 
2-8°C
solubility 
H2O: 0.5 M at 20 °C, clear, colorless
pka
1.5(at 25℃)
form 
Crystals or Crystalline Powder
color 
White
PH
4.5-6.0 (25℃, 0.5M in H2O)
Water Solubility 
5-10 g/100 mL at 23.5 ºC
λmax
λ: 260 nm Amax: 0.006
λ: 280 nm Amax: 0.005
Merck 
14,9074
JECFA Number
1435
BRN 
1751215
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
XOAAWQZATWQOTB-UHFFFAOYSA-N
CAS DataBase Reference
107-35-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Aminoethanesulfonic acid(107-35-7)
EPA Substance Registry System
Ethanesulfonic acid, 2-amino-(107-35-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  2
RTECS  WX0175000
TSCA  Yes
HS Code  29211980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Taurine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 86329 Taurine BioUltra, ≥99.5% (T) 107-35-7 25g $82.9 2018-11-13 Buy
Sigma-Aldrich 1643361 Taurine United States Pharmacopeia (USP) Reference Standard 107-35-7 100mg $303 2018-11-13 Buy
TCI Chemical A0295 2-Aminoethanesulfonic Acid >98.0%(T) 107-35-7 25g $12 2018-11-22 Buy
TCI Chemical A0295 2-Aminoethanesulfonic Acid >98.0%(T) 107-35-7 500g $36 2018-11-22 Buy
Alfa Aesar A12403 Taurine, 99% 107-35-7 100g $28.7 2018-11-13 Buy

Taurine Chemical Properties,Uses,Production

Description

Taruine is an organic compounds that widely existing in animal tissues. It is a sulfur amino acid, but not being used for protein synthesis. It is rich in the brain, breasts, gallbladder and kidney. It is an essential amino acid in the pre-term and newborn infants of human. It has various kinds of physiological functions including being as a neurotransmitter in the brain, conjugation of bile acids, anti-oxidation, osmoregulation, membrane stabilization, modulation of calcium signaling, regulating the cardiovascular function as well as the development and function of skeletal muscle, the retina, and the central nervous system. It can be manufactured through the ammonolysis of isethionic acid or the reaction of aziridine with sulfurous acid. Because of its highly important physiological role, it can be supplied to energy drinks. It can also be used in cosmetics to maintain skin hydration, and used in some contact lens solution.

History

As the conditionally essential amino acid of the human body, it is a kind of β- sulphamic acid. In mammalian tissues, it is a metabolite of methionine and cystine. It was first isolated from ox bile in 1827, hence the name taurine. It commonly exists in the form of free amino acids in various tissues of animals, but not goes into proteins without combination. Taurine is rarely found in plants. Early on, people had considered it a bile acid binding agent of taurocholic combined with cholic acid. However, recent studies have shown that taurine has many important biological functions apart from the above mentioned forming taurocholic acid and participating in the digestion and absorption of lipids.It is important nutrients for normal development and function of cranial nerve to play the role in adjusting a variety of nerve cells of the central nervous system; taurine in retina accounts for 40% to 50% of total free amino acid, which is necessary for maintaining the structure and function of photoreceptor cells; affecting the myocardial contracts dint, regulating calcium metabolism, controlling arrhythmia, lowering blood pressure, etc; maintaining cellular antioxidant activity to protect the tissues from damaging free radicals; decreasing platelet aggregation and so on. As the metabolites containing sulphur amino acids, mammals have different abilities to synthesize taurine: The synthetic ability of rats and dogs is stronger, the synthetic ability of human and primate is lower, while that of kits and human infants is very low. Taurine in the infant mainly comes from the diet, so it is recommended to supplement the taurine in the baby's diet. Foods with a higher content of taurine include conch, clam, mussel, oyster, squid and other shellfish food, which chould be up to 500 ~ 900mg/100g in the table part; the content in fish is comparably different; the content in poultry and offal is also rich; the content in human milk is higher than cow milk; taurine is not found in eggs and vegetable food.

Medicinal effect

Preparation

  1. Extract from the mollusk such as fish, shellfish and so on.
  2. After reacting to form sodium 2-hydroxyethanesulfonate at 70℃with ethylene oxide and sodium hydrogen sulfite as raw materials, this product can be obtained by further aminolysis and desalination [1].
  3. It can be obtained by reaction between ethylene imine and sulfurous acid [1].
  4. It can be obtained with nitroethylene and sodium bisulfite as raw materials[1]. CH2=CHNO2+NaHSO3→[1]
  5. It can be obtained preparing by sulfonation of sodium sulfite and aminolysis in liquid ammonia with sodium sulfite as the raw material [1].
  6. Ethanolamine is used as the raw material to react with hydrochloric acid to form chloroethylamine hydrochloride, which is reacted with sodium sulfite to produce sodium ethylamine sulfonate. This product can be obtained by desalination with dilute sulphuric acid [1].
  7. Use aziridine as the raw material and react with sulfur dioxide and water to obtain this product [1].
  8. Like 6, it can be obtained by using bromoethylamine hydrobromide as the raw material and reacting with sodium sulfite [1].
  9. Use 1, 2-dichloroethane as the raw material and react with sodium sulfite to produce chloroethanesulfonic acid sodium salt. React with ammonia under heating with pressure to form sodium amino ethyl sulfonate. Then it can be prepared by hydrochloric acid-acidification desalination [1].
  10. Like 9, we use hydroxyethanesulphonic acid as the raw material and react with ammonia under heating with pressure to obtain this product [1].
  11. We use 2,2-dimethyl thiazoles as the raw material, hydrogen peroxide or manganese dioxide as the oxidizing agent. This product can be obtained by oxidation under pressure [1], with acetone as by-product at the same time.
  12. It can be obtained by using 2-amino alcohol monoester as the raw material and reacting with sodium sulfite [1]. (H2NCH2CH2O)HSO3+Na2SO3→ [1]+Na2SO4
  13. N- vinyl propanamide is used as the raw material to react with sodium bisulfite to produce sodium 2- propane amino ethyl sulfonate. Then this product can be obtained by acidification desalination and hydrolysis.

References

https://en.wikipedia.org/wiki/Taurine
https://pubchem.ncbi.nlm.nih.gov/compound/taurine#section=Top

Chemical Properties

Taurine is a naturally occurring amino acid with a bitter taste and sharp flavor. It is a nonessential amino acid by definition because the body can synthesize it from methionine and cysteine.

Chemical Properties

White crystalline powder

Occurrence

Reported found in beef, black beans, chicken, chick peas, clams, cod, fish, lamb, milk, octopus, oysters, pistachios, pork, scallops, shrimp and other natural sources.

Uses

vitamin B1, enzyme cofactor

Uses

Taurine is an organic acid found in animal tissues and is a major constituent of bile. Taurine has many biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stab ilization and modulation of calcium signaling.

Definition

ChEBI: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral suppleme t in the treatment of disorders such as cystic fibrosis and hypertension.

General Description

Large white crystals or white powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Taurine is an amino acid found in combination with bile acids [Hawley].

Hazard

Toxic by ingestion.

Health Hazard

ACUTE/CHRONIC HAZARDS: Taurine evolves highly toxic fumes when heated to decomposition, and may cause irritation on contact.

Fire Hazard

Flash point data are not available for Taurine, but Taurine is probably combustible.

Biological Activity

One of the most abundant free amino acids in the brain. A partial agonist at the inhibitory glycine receptor.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Taurine Preparation Products And Raw materials

Raw materials

Preparation Products


Taurine Suppliers

Global( 499)Suppliers
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View Lastest Price from Taurine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-04 Taurine in stock Factory
107-35-7
US $1.00 / kg 1kg High quality purified manufacturer Top 3 production capacity Factory Chemwill Asia Co.,Ltd.
2019-04-03 Taurine in stock GMP Factory
107-35-7
US $1.00 / KG 1KG GMP Factory in China Top 3 largest production capacity Factory Chemwill Asia Co.,Ltd.
2019-05-14 Taurine
107-35-7
US $1.00 / g 1g 99% 200000kg Cangzhou Wanyou New Material Technology Co.,Ltd

Taurine Spectrum


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