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Flunarizine

CAS No.
52468-60-7
Chemical Name:
Flunarizine
Synonyms
Sibelium;Fluarizine;FLUNARIZINE;(e)-piperazin;Flunarizine USP/EP/BP;Flunarizine Dihydrate;(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine;(e)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine;1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine;1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine
CBNumber:
CB2757102
Molecular Formula:
C26H26F2N2
Molecular Weight:
404.49
MDL Number:
MFCD00242731
MOL File:
52468-60-7.mol
MSDS File:
SDS
Last updated:2024-03-19 15:37:50

Flunarizine Properties

Boiling point 511.3±50.0 °C(Predicted)
Density 1.170±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 6.99±0.10(Predicted)
CAS DataBase Reference 52468-60-7(CAS DataBase Reference)
FDA UNII R7PLA2DM0J
NIST Chemistry Reference Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (e)-(52468-60-7)
ATC code N07CA03

Flunarizine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0002726 FLUNARIZINE 95.00% 52468-60-7 1G $160.65 2021-12-16 Buy
Medical Isotopes, Inc. D33984 Flunarizine-d8dHCl 52468-60-7 1mg $600 2021-12-16 Buy
Medical Isotopes, Inc. D33984 Flunarizine-d8dHCl 52468-60-7 5mg $1670 2021-12-16 Buy
American Custom Chemicals Corporation API0002726 FLUNARIZINE 95.00% 52468-60-7 25G $2243.59 2021-12-16 Buy
AHH MT-51823 Flunarizine 98% 52468-60-7 25g $880 2021-12-16 Buy
Product number Packaging Price Buy
API0002726 1G $160.65 Buy
D33984 1mg $600 Buy
D33984 5mg $1670 Buy
API0002726 25G $2243.59 Buy
MT-51823 25g $880 Buy

Flunarizine Chemical Properties,Uses,Production

Description

Flunarizine is the difluorinated derivative of cinnarizine. Thus, its preparation and therapeutic use are identical to those of cinnarizine.

Originator

Sibelium,Janssen,W. Germany,1977

Uses

Vasodilator.

Definition

ChEBI: Flunarizine is a diarylmethane.

Manufacturing Process

A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.

Therapeutic Function

Vasodilator

World Health Organization (WHO)

Flunarizine, an antihistaminic and vasodilator agent, was introduced into medicine in 1970. It is indicated for the treatment of central and peripheral vascular disorders. However, its effectiveness in these conditions has not been convincingly demonstrated, and its use has been associated with adverse reactions involving the central nervous system, including extrapyramidal disturbances and depression. This has led several regulatory authorities to restrict the approved indications for products containing flunarizine.

1522375-87-6
1100-88-5
693765-11-6
52468-60-7
Synthesis of Flunarizine from 1-Piperazineacetaldehyde, 4-[bis(4-fluorophenyl)methyl]- and Benzyltriphenylphosphonium chloride
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View Lastest Price from Flunarizine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Flunarizine USP/EP/BP pictures 2021-08-13 Flunarizine USP/EP/BP
52468-60-7
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
Flunarizine  pictures 2020-05-12 Flunarizine
52468-60-7
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
  • Flunarizine  pictures
  • Flunarizine
    52468-60-7
  • US $1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine (e)-piperazin 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)- Sibelium Fluarizine 1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine FLUNARIZINE (e)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]- Flunarizine USP/EP/BP Flunarizine Dihydrate 52468-60-7 C26H26F2N2