H-PRO-LEU-GLY-NH2
- CAS No.
- 2002-44-0
- Chemical Name:
- H-PRO-LEU-GLY-NH2
- Synonyms
- MELANOSTATIN;MIF-1;PRO-LEU-GLY-NH2;MIF-I;PLG-NH2;MSH-R-IF;MIF, AMIDE;Melanostatin I;PRO-LEU-GLY AMIDE;H-PRO-LEU-GLY-NH2
- CBNumber:
- CB2779319
- Molecular Formula:
- C13H24N4O3
- Molecular Weight:
- 284.35
- MDL Number:
- MFCD00037866
- MOL File:
- 2002-44-0.mol
- MSDS File:
- SDS
| Melting point | 122-123 °C(Solv: water (7732-18-5)) |
|---|---|
| Boiling point | 626.2±55.0 °C(Predicted) |
| Density | 1.147±0.06 g/cm3(Predicted) |
| storage temp. | -15°C |
| solubility | ≥59.1 mg/mL in DMSO; ≥50 mg/mL in EtOH; ≥50 mg/mL in H2O |
| pka | 14.10±0.20(Predicted) |
| form | Lyophilized powder |
| Water Solubility | Soluble in water. |
| Sequence | H-Pro-Leu-Gly-NH2 |
| FDA UNII | 3KY24B4Q62 |
H-PRO-LEU-GLY-NH2 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J60045 | Melanocyte-Stimulating Hormone-Release Inhibiting Factor, synthetic | 2002-44-0 | 250mg | $58.4 | 2023-06-20 | Buy |
| Alfa Aesar | J60045 | Melanocyte-Stimulating Hormone-Release Inhibiting Factor, synthetic | 2002-44-0 | 1g | $201 | 2023-06-20 | Buy |
| Tocris | 1929 | Melanocyte-stimulatinghormonereleaseinhibitingfactor | 2002-44-0 | 10 | $72 | 2021-12-16 | Buy |
| Usbiological | M2868-72S | Melanocyte Stimulating Hormone Release Inhibiting Factor | 2002-44-0 | 1mg | $531 | 2021-12-16 | Buy |
| Usbiological | 255779 | Melanocyte-stimulating hormone release inhibiting factor | 2002-44-0 | 10mg | $310 | 2021-12-16 | Buy |
H-PRO-LEU-GLY-NH2 Chemical Properties,Uses,Production
Uses
L-Prolyl-L-leucylglycinamide is shown to be effective in treating human depression with greater efficacy and faster onset of action than traditional anti-depressants.Also, it is used in the synthesis of novel analogs to be tested for their ability to enhance the binding of [3H]-N-propylnorapomorphine to short isoform of human dopamine D2 receptors.
Definition
ChEBI: Melanostatin is an oligopeptide.
Biological Activity
melanocyte stimulating hormone release inhibiting factor,(c13h24n4o3), a tri-peptide with the sequence h2n-pro-leu-gly-amide, mw= 284.35. melanocyte-inhibiting factor (also known as pro-leu-gly-nh2, melanostatin, msh release-inhibiting hormone or mif-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body(1). mif-1 produces multiple effects, both blocking the effects of opioid receptor activation(2), while at the same time acting as a positive allosteric modulator of the d2 and d4 dopamine receptor subtypes, as well as inhibiting release of other neuropeptides such as alpha-msh, and potentiating melatonin activity(3). mif-1 is unusually resistant to metabolism in the bloodstream, and crosses the blood–brain barrier easily, though it is poorly active orally and is usually injected.figure1 formula of melanocyte stimulating hormone release inhibiting factor
storage
-20°C (desiccate)
References
1. Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America 68 (7): 1428–33.2. Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences 34 (26): 2559–66.3. Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 inmovement disorders". The International Journal of Neuroscience 52 (1-2): 59–65.
H-PRO-LEU-GLY-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
H-PRO-LEU-GLY-NH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
View Lastest Price from H-PRO-LEU-GLY-NH2 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-14 | H-PRO-LEU-GLY-NH2
2002-44-0
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- H-PRO-LEU-GLY-NH2
2002-44-0
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
2002-44-0(H-PRO-LEU-GLY-NH2)Related Search:
1of4