GSK-3BETA INHIBITOR XII
- CAS No.
- 601514-19-6
- Chemical Name:
- GSK-3BETA INHIBITOR XII
- Synonyms
- TWS11;TWS S;TWS119;CS-445;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;GSK-3BETA INHIBITOR XII;GSK-3β Inhibitor, TWS119
- CBNumber:
- CB2803764
- Molecular Formula:
- C18H14N4O2
- Molecular Weight:
- 318.33
- MDL Number:
- MFCD09037535
- MOL File:
- 601514-19-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
GSK-3BETA INHIBITOR XII price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 361554 | GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem | 601514-19-6 | 1mg | $172 | 2024-03-01 | Buy |
| Sigma-Aldrich | 361554 | GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem | 601514-19-6 | 5mg | $532 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1271 | TWS119 ≥98% (HPLC) | 601514-19-6 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1271 | TWS119 ≥98% (HPLC) | 601514-19-6 | 25MG | $451 | 2023-06-20 | Buy |
| Cayman Chemical | 10011251 | TWS119 ≥90% | 601514-19-6 | 1mg | $37 | 2024-03-01 | Buy |
GSK-3BETA INHIBITOR XII Chemical Properties,Uses,Production
Uses
TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.
Uses
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
Definition
ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.
General Description
A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biological Activity
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Biochem/physiol Actions
TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
target
GSK-3β
storage
Store at +4°C
References
[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.
GSK-3BETA INHIBITOR XII Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29627 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12757 | 58 |
View Lastest Price from GSK-3BETA INHIBITOR XII manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | GSK-3BETA INHIBITOR XII
601514-19-6
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
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- GSK-3BETA INHIBITOR XII
601514-19-6
- US $2.00 / kg
- 99%
- Career Henan Chemical Co