DERAMCICLANE
- CAS No.
- 120444-71-5
- Chemical Name:
- DERAMCICLANE
- Synonyms
- EGIS-3886;DERAMCLCLANE;DERAMCICLANE;DERAMCICLANE ISO 9001:2015 REACH;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-
- CBNumber:
- CB2818661
- Molecular Formula:
- C20H31NO
- Molecular Weight:
- 301.47
- MDL Number:
- MFCD00865305
- MOL File:
- 120444-71-5.mol
Boiling point | 375.2±25.0 °C(Predicted) |
---|---|
Density | 1.01±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | Oil |
pka | pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain) |
color | Light yellow to yellow |
FDA UNII | O5KFK61E74 |
DERAMCICLANE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | API0007969 | DERAMCICLANE 95.00% | 120444-71-5 | 5MG | $500.31 | 2021-12-16 | Buy |
CSNpharm | CSN21600 | Deramciclane | 120444-71-5 | 25mg | $1225 | 2021-12-16 | Buy |
CSNpharm | CSN21600 | Deramciclane | 120444-71-5 | 1mg | $204 | 2021-12-16 | Buy |
DERAMCICLANE Chemical Properties,Uses,Production
in vitro
Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are further characterized using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.
in vivo
Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C < /sub> receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.
DERAMCICLANE Preparation Products And Raw materials
DERAMCICLANE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8132 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
China Langchem Inc. | 0086-21-58956006 | China | 7815 | 57 | |
shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3089 | 55 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |