butizide
- CAS No.
- 2043-38-1
- Chemical Name:
- butizide
- Synonyms
- S-3500;Su-6187;Butizid;Modenol;Saltucin;butizide;Eunephran;Butizidum;Buthiazide;Thiabutazide
- CBNumber:
- CB2875097
- Molecular Formula:
- C11H16ClN3O4S2
- Molecular Weight:
- 353.85
- MDL Number:
- MFCD00867351
- MOL File:
- 2043-38-1.mol
| Melting point | 214-217°C |
|---|---|
| Boiling point | 562.7±60.0 °C(Predicted) |
| Density | 1.4221 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.01±0.40(Predicted) |
| color | White to Yellow |
| FDA UNII | W00SSD35VW |
butizide price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 263352 | Buthiazide | 2043-38-1 | 25mg | $355 | 2021-12-16 | Buy |
| TRC | B690035 | Buthiazide | 2043-38-1 | 2.5g | $1355 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010900 | BUTHIAZIDE 95.00% | 2043-38-1 | 2.5G | $1947 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB19384 | Buthiazide | 2043-38-1 | 500mg | $210 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010900 | BUTHIAZIDE 95.00% | 2043-38-1 | 250MG | $315 | 2021-12-16 | Buy |
butizide Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Saltucin,Boehringer Mannheim,W. Germany,1961
Uses
Diuretic and antihypertensive.
Definition
ChEBI: Butizide is a benzothiadiazine.
Manufacturing Process
Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C.
Therapeutic Function
Diuretic, Antihypertensive
butizide Preparation Products And Raw materials
butizide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 +86-18029359586 | sales@mkmeditech.com | China | 1134 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1958 | 55 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| Suzhou Laihui Biotechnology Co., Ltd. | 180-13160973 +86-18013160973 | rywaybio@gmail.com | China | 296 | 55 |
| Jinan Guoding Pharmaceutical Technology Co., Ltd. | 13153106106 | sales@guodingpharma.com | China | 481 | 58 |