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butizide

butizide
butizide structure
CAS No.
2043-38-1
Chemical Name:
butizide
Synonyms
S-3500;Su-6187;Butizid;Modenol;Saltucin;butizide;Eunephran;Buthiazide;Thiabutazide;Isobutylhydrochlorothiazide
CBNumber:
CB2875097
Molecular Formula:
C11H16ClN3O4S2
Formula Weight:
353.85
MOL File:
2043-38-1.mol

butizide Properties

Melting point:
214-217°C
Boiling point:
562.7±60.0 °C(Predicted)
Density 
1.4221 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Refrigerator
pka
9.01±0.40(Predicted)
FDA UNII
W00SSD35VW

butizide Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Originator

Saltucin,Boehringer Mannheim,W. Germany,1961

Uses

Diuretic and antihypertensive.

Manufacturing Process

Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.

Therapeutic Function

Diuretic, Antihypertensive

butizide Preparation Products And Raw materials

Raw materials

Preparation Products


butizide Suppliers

Global( 18)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32358 50
Cato Research Chemicals Inc. +1-541-2553640
+1-541-2553641 info@cato-chem.com United States 1958 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 400-002-6226
sales@biochemall.cn China 54467 58
Nanjing Shizhou Biotechnology Co., Ltd 18013869214
rose.shi@synzest.com China 178 58
Nanjing Shizhou Biology Technology Co.,Ltd 15850508050 025-85560043-
025-85563444 cindy.huang@synzest.com China 9781 58
Energy Chemical 400-005-6266 021-58432009-
021-58436166 marketing@energy-chemical.com China 44735 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369-
3477467573@qq.com China 8623 58
Carbosynth --
-- sales@carbosynth.com United Kingdom 6478 58

2043-38-1(butizide)Related Search:


  • 6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • butizide
  • Buthiazide
  • Thiabutazide
  • Eunephran
  • S-3500
  • Saltucin
  • Su-6187
  • 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-chloro-3-isobutyl-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-Chloro-3,4-dihydro-3-(2-Methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide
  • Butizid
  • Isobutylhydrochlorothiazide
  • Modenol
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(2-methylpropyl)-, 1,1-dioxide
  • 2043-38-1
  • C11H16ClN3O4S2
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
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