Aprindine
- CAS No.
- 37640-71-4
- Chemical Name:
- Aprindine
- Synonyms
- AC-1802;aprindin;Aprindine;aprinidine;Lilly-83846;Aprindine USP/EP/BP;3-(diethylamino)propyl-indan-2-yl-phenyl-amine;N,N'-Diethyl-N'-2-indanyl-N'-phenyl-1,3-Prop-anediamine;n-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-3-propanediamine;n-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-1,3-propanediamine
- CBNumber:
- CB2875279
- Molecular Formula:
- C22H30N2
- Molecular Weight:
- 322.49
- MDL Number:
- MFCD00864718
- MOL File:
- 37640-71-4.mol
- MSDS File:
- SDS
| Melting point | 120-121 °C |
|---|---|
| Boiling point | 450.9±45.0 °C(Predicted) |
| Density | 1.046±0.06 g/cm3(Predicted) |
| pka | pKa 4.53 (H2O) (Uncertain);10.16(H2O) (Uncertain) |
| FDA UNII | 5Y48085P9Q |
| ATC code | C01BB04 |
Aprindine Chemical Properties,Uses,Production
Originator
Amidonal,Madaus,W. Germany,1976
Uses
depressant (anti-arrhythmic).
Definition
ChEBI: Aprindine is a member of indanes.
Manufacturing Process
104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are
introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen.
37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3
hours at room temperature.
119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After
agitation during 1 hour at room temperature, the reaction mixture is refluxed
and stirred under nitrogen during 21 hours. The mixture is then allowed to
cool and poured onto ice. The obtained aqueous phase is extracted by means
of 500 cm3 of benzene. The benzene extract is washed two times with 200
cm3 of water and the benzene is then evaporated.
The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained
solution is evaporated to dryness and the oily residue is recrystallized from
ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl-
2-aminoindane are obtained, MP 208° to 210°C.
The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g
(0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a
suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous
solution to dryness, drying by means of benzene, filtering the formed sodium
chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g
(95%) of monohydrochloride are obtained, MP 120° to 121°C.
brand name
Fibocil (Lilly).
Therapeutic Function
Antiarrhythmic
Side effects
Aprindine has a sustained activity. Because of serious side effects (agranulocytosis), aprindine should only be used for life-threatening arrhythmias otherwise refractory to therapy .
Aprindine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9309 | 58 |
| Wuhan Magic Biological Technology Co., Ltd. | 18872289958、027-52304252、3400508168 | 3400508168@qq.com | China | 1910 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366 15920483169 | sales@chem-strong.com | China | 18810 | 58 |
| Shaanxi Xihua Chemical Industry Co., Ltd | 17691182729 15529505138 | 1021@dideu.com | China | 10009 | 58 |
View Lastest Price from Aprindine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | Aprindine USP/EP/BP | US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Aprindine USP/EP/BP
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited