Ethyl Biscoumacetate
- CAS No.
- 548-00-5
- Chemical Name:
- Ethyl Biscoumacetate
- Synonyms
- Trombil;Pelentan;Trombarin;Trombolysan;Ethyl Biscoumacetate;DI(4-oxi-cymarinyl-3);Ethyl Biscoumacetate USP/EP/BP;ethyl bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate;ethyl 2,2-bis(2-hydroxy-4-oxochromen-3-yl)acetate;ethyl 2,2-bis(2-hydroxy-4-oxo-chromen-3-yl)ethanoate
- CBNumber:
- CB2875406
- Molecular Formula:
- C22H16O8
- Molecular Weight:
- 408.36
- MDL Number:
- MFCD00128073
- MOL File:
- 548-00-5.mol
| Melting point | 177-182° and mp 154-157° |
|---|---|
| Boiling point | 448.92°C (rough estimate) |
| Density | 1.3259 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | pKa 7.5 (Uncertain) |
| color | White |
| Water Solubility | 54.31mg/L(temperature not stated) |
| FDA UNII | 08KL644731 |
| ATC code | B01AA08 |
SAFETY
Risk and Safety Statements
| RIDADR | 2811 |
|---|---|
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice, rats (g/kg): 0.88, 0.26 orally; 0.32, 1.1 i.p. (Gruber) |
Ethyl Biscoumacetate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E900100 | EthylBiscoumacetate | 548-00-5 | 100mg | $155 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | FRL0000102 | ETHYL BISCOUMACETATE 95.00% | 548-00-5 | 1G | $236.25 | 2021-12-16 | Buy |
| Aronis compounds | BBC/596 | ethylbis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate | 548-00-5 | 1g | $175 | 2021-12-16 | Buy |
Ethyl Biscoumacetate Chemical Properties,Uses,Production
Chemical Properties
White, crystalline solid; odorless; bitter taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water.
Originator
Tromexan,Geigy,US,1950
Uses
Anticoagulant.
Uses
Medicine (anticoagulant).
Definition
A synthetic derivative of bishydroxycoumarin.
Manufacturing Process
7 g of benzotetronic acid are dissolved in 750 cc of water at boiling
temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl
alcoholate are added. After a short while the liquid becomes turbid and
gradually a white deposit is separated. The deposit is filtrated and dried in
vacuo. The melting point is 172°C to 174°C; after recrystallization from
methyl alcohol 153°C to 154°C.
The crude product is dissolved in sodium lye, filtrated by means of animal
charcoal precipitated by means of hydrochloric acid, and recrystallized from
methyl alcohol. The melting point is 153°C to 154°C.
Therapeutic Function
Anticoagulant
Synthesis
Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy- 3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine, but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde.
Ethyl Biscoumacetate Preparation Products And Raw materials
Ethyl Biscoumacetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11732 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9926 | 58 |
| Aronis | -- | aronis@aronis.ru | Russia | 6593 | 60 |
View Lastest Price from Ethyl Biscoumacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-05 | Ethyl Biscoumacetate USP/EP/BP
548-00-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Ethyl Biscoumacetate USP/EP/BP
548-00-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited