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ChemicalBook >> CAS DataBase List >>2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)-

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)-

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- Structure
2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- structure
CAS No.
2603528-97-6
Chemical Name:
2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)-
Synonyms
ART558;(2S,3R)-1-(3-Cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)-3-hydroxy-N-methyl-N-(m-tolyl)pyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)-
CBNumber:
CB29374005
Molecular Formula:
C21H21F3N4O2
Molecular Weight:
418.41
MDL Number:
MFCD34474085
MOL File:
2603528-97-6.mol
Last updated:2025-07-14 15:53:57
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2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- Properties

Boiling point 621.9±55.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
pka 13.58±0.40(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- Chemical Properties,Uses,Production

Uses

ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer[1].

References

[1] Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636. DOI:10.1038/s41467-021-23463-8

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3479 58
Hangzhou J&H Chemical Co., Ltd. 0571-+86-571-87396432 sales@jhechem.com China 14906 59
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4650 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 10016 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Hangzhou J&H Chemical Co., Ltd. 59
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai SuperLan Chemcial Technique Centre 58

View Lastest Price from 2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ART558 pictures 2025-07-14 ART558
2603528-97-6
 US $155.00-587.00 / mg 99.67% 10g TargetMol Chemicals Inc.
  • ART558 pictures
  • ART558
    2603528-97-6
  • US $155.00-587.00 / mg
  • 99.67%
  • TargetMol Chemicals Inc.

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- Spectrum

2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)-(2603528-97-6)1HNMR
2-Pyrrolidinecarboxamide, 1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-, (2S,3R)- ART558 (2S,3R)-1-(3-Cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)-3-hydroxy-N-methyl-N-(m-tolyl)pyrrolidine-2-carboxamide 2603528-97-6