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Lapatinib ditosylate

Lapatinib ditosylate structure

CAS No.: 388082-78-8

Chemical Name:: Lapatinib ditosylate

Synonyms: Lapatinib ditosylate Monohydrate;Lapatinib tosilate;Lapatinib ditosylate hydrate;Lapatinb;GW2016 ditosylate;GW-572016;GW572016;lapatinib(GW572016);Lapatinib Ditosilate;Lapatinib ditosylate;xyene sulfonate lapatinib

CBNumber:: CB2966227

Molecular Formula:: C41H40ClFN4O11S3

Molecular Weight:: 925.46

MDL Number:: MFCD09264195

MOL File:: 388082-78-8.mol

MSDS File:: SDS

Last updated:2024-03-18 13:30:28

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Lapatinib ditosylate Properties

Melting point	>200oC (dec.)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	Yellow
CAS DataBase Reference	388082-78-8(CAS DataBase Reference)
FDA UNII	G873GX646R
NCI Dictionary of Cancer Terms	lapatinib ditosylate
NCI Drug Dictionary	lapatinib ditosylate

SAFETY

Risk and Safety Statements

Hazard statements	H413

Lapatinib ditosylate price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	L175813	LapatinibDitosylateMonohydrate	388082-78-8	10mg	$85	2021-12-16	Buy
Usbiological	281198	Lapatinib ditosylate	388082-78-8	50mg	$375	2021-12-16	Buy
Usbiological	015474	Lapatinib Ditosylate	388082-78-8	5mg	$425	2021-12-16	Buy
Matrix Scientific	090594	Lapatinib ditosylate hydrate 98%	388082-78-8	250mg	$567	2021-12-16	Buy
Biorbyt Ltd	orb180754	Lapatinib ditosylate >98%	388082-78-8	250mg	$615.4	2021-12-16	Buy

Product number	Packaging	Price	Buy
L175813	10mg	$85	Buy
281198	50mg	$375	Buy
015474	5mg	$425	Buy
090594	250mg	$567	Buy
orb180754	250mg	$615.4	Buy

Lapatinib ditosylate Chemical Properties,Uses,Production

Uses

binds to a(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors atypical antipsychotic agent

Uses

anticancer

Uses

Lapatinib ditosylate monohydrate is a form of Lapatinib I, an orally active drug for breast cancer as a dual EGFR and erbB-?2 inhibitor.

Definition

ChEBI: Lapatinib ditosylate monohydrate is a member of quinazolines.

General Description

Lapatinib is available in 250-mg tablets for oral administrationand is used in combination with cabecitabine in thetreatment of breast cancer for those patients that over expressthe type 2 EGF-R and who have previously receivedtaxane, anthracycline, and trastuzumab therapy. The type 2EGF-R is one subtype of this receptor and is also known asHER2 or ErbB-2. The agent is a receptor TK inhibitor targetingthe ErbB-1 and ErbB-2 subtypes. Binding occurs atthe ATP-binding site and thereby prevents phosphorylationand the subsequent activation of other kinase enzymes.ErbB-1 overexpression occurs in approximately27% to 30% of breast cancers, while ErbB-2 is over expressedin 20% to 25% of cases.The agent has demonstratedIC50 values of ＜0.2μM against ErbB-1 and 2 fromseveral different cancer cell lines and dissociates slowly(t_1/2＝300 min) from these receptor TKs.The drug isboth a substrate and an inhibitor of the efflux transportersPgp and BCRP. It is also an inhibitor of the hepatic uptaketransporter OATP1B1, which is an organic anion transporter.The absorption of lapatinib is incomplete andvariable after oral administration. The agent is extensivelymetabolized by CYP3A4 and CYP3A5, with minor contributionsfrom CYP2C19 and CYP2C8. Lapatinib inhibitsCYP3A and CYP2C8 at clinically relevant concentrations.The agent is highly (99%) protein bound and eliminatedprimarily in the feces. The half-life of the agent increaseupon repeated dosing, taking 6 days to reach steady statethat gives an effective half-life of 24 hours. The most commonlyseen adverse effects of lapatinib therapy are skinrash and diarrhea. Skin rash is commonly seen with manyof the other TK inhibitors and agents that target ErbB-1.Lapatinib-induced diarrhea is usually mild to moderate.There have been reports of decreases in left ventricularejection fraction associated with the agent, although thisappears to occur only rarely and is reversible upon discontinuationof therapy.

target

EGFR

Lapatinib ditosylate synthesis

Synthesis of Lapatinib ditosylate from 2-Aminoethylmethyl sulfone and p-Toluenesulfonic acid and 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

Lapatinib ditosylate Preparation Products And Raw materials

Raw materials

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 2-Aminoethylmethylsulfone hydrochloride 2-Aminoethylmethyl sulfone p-Toluenesulfonic acid

Preparation Products

Lapatinib

Lapatinib ditosylate Suppliers

Global( 340)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15746	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	+86-0531-69954981 +8615666777973	dwyane.wang@boyuanpharm.com	China	211	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Duling International Trade Co. LTD	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	58
hebei hongtan Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from Lapatinib ditosylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-22	Lapatinib ditosylate 388082-78-8	US $30.00 / kg	1kg	99%	2000kg	hebei hongtan Biotechnology Co., Ltd
2023-12-29	Lapatinib Ditosylate 388082-78-8	US $0.00-0.00 / kg	1kg	99%，single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd
2023-11-28	Lapatinib ditosylate 388082-78-8	US $50.00 / kg	1kg	99.8%	15tons	Hebei Duling International Trade Co. LTD

Lapatinib ditosylate
388082-78-8
US $30.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

Lapatinib Ditosylate
388082-78-8
US $0.00-0.00 / kg
99%，single impurity＜0.1
Nanjing Fred Technology Co., Ltd

Lapatinib ditosylate
388082-78-8
US $50.00 / kg
99.8%
Hebei Duling International Trade Co. LTD

388082-78-8(Lapatinib ditosylate)Related Search:

Lapatinib PENTA(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Pazopanib Osimertinib mesylate Baricitinib

Afatinib 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate Cabazitaxel Pazopanib Hydrochloride Regorafenib

Afatinib dimaleate AZD-9291 Nintedanib Ethanesulfonate Salt 2-mercapto-N-methylbenzamide N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 2-Aminoethylmethylsulfone hydrochloride p-Toluenesulfonic acid

1of4

Lapatinib ditosylate benzenesulfonic acid: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine: h ydrate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) Lapatinib Ditosilate Lapatinib, Tykerb, GW572016 Lapatinib Ditosylate (GW-572016) lapatinib(GW572016) bis(N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine) tetrakis(4-Methylbenzenesulfonate) hydrate Lapatinb 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate (9CI) N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate xyene sulfonate lapatinib (N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine)bis(4-Methylbenzenesulfonate) hydrate Lapatinib ditosylate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)-quinazolin-4-ylamine ditosylate hydrate Rapatinib bis - toluene sulfonate GW-572016;GW572016 Lapatinib xylene sulfonate N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, 4-methylbenzenesulfonate, hydrate (1:2:1) Lapatinib Ditosylate MonohydrateI Lapatinib ditosylate hydrat Lapatinib ditoluenesulfonate monohydrate Lapatinib tosilate hydrate Lapatinib ditosylate ISO 9001：2015 REACH Lapatinib D4 DitosylateQ: What is Lapatinib D4 Ditosylate Q: What is the CAS Number of Lapatinib D4 Ditosylate Lapatinib tosilate Lapatinib ditosylate Monohydrate Lapatinib ditosylate hydrate Lapatinib p-toluenesulfonate monohydrate GW2016 ditosylate 388082-78-8 388083-78-8 388082-78-9 C29H26ClFN4O4S2C7H8O3 C29H26ClFN4O4S2C7H8O3S C41H40ClFN4O11S3 C29H26ClFN4O4S2C74H8O3SH2O C29H26ClFN4O4S2C7H8O3SH2O C43H44ClFN4O11S3 2C7H8O3SC29H26ClFN4O4S anti-neoplastic Inhibitors Anti-cancer&immunity Lapatinib API 388082-78-8