R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE
- CAS No.
- 253446-15-0
- Chemical Name:
- R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE
- Synonyms
- R(+)-SKF-81297;R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE;(5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
- CBNumber:
- CB2972828
- Molecular Formula:
- C16H16ClNO2.BrH
- Molecular Weight:
- 370.672
- MDL Number:
- MFCD00671792
- MOL File:
- 253446-15-0.mol
Last updated:2023-04-23 13:52:06
| solubility | H2O: soluble6mg/mL |
|---|---|
| form | solid |
| color | white to off-white |
| optical activity | [α]22/D +15.14°, c = 0.52 in DMF(lit.) |
| FDA UNII | J494DH8JRC |
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S179 | R(+)-SKF-81297 hydrobromide ≥98% (HPLC), solid | 253446-15-0 | 5mg | $783 | 2024-03-01 | Buy |
| TRC | R700955 | R(+)-SKF-81297 hydrobromide | 253446-15-0 | 2.5mg | $185 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0005583 | R(+)-SKF-81297 95.00% | 253446-15-0 | 5MG | $504.64 | 2021-12-16 | Buy |
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Chemical Properties,Uses,Production
Uses
R(+)-SKF-81297 Hydrobromide is a dopamine D1 agonist.
Uses
R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:
- to test it effect on the spike firing in rat retinal ganglion cells
- in human embryonic kidney (HEK) 293T cells
- to test its inhibitory effect in microglial cells
Biochem/physiol Actions
SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Suppliers
Global( 7)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Anhua Biotechnology Co., Ltd. | 021-61263375 18168859245 | China | 5958 | 58 | |
| Wuxi maimo topp biotechnology co., LTD | 15861600115 | lisa-li@mimotopes.cn | China | 5854 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Sigma-Aldrich | 80 |
| Shanghai Anhua Biotechnology Co., Ltd. | 58 |
| Wuxi maimo topp biotechnology co., LTD | 58 |
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE
R(+)-SKF-81297
(5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
253446-15-0