PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
- CAS No.
- 724709-68-6
- Chemical Name:
- PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
- Synonyms
- PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM;4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenylbutoxy)-
- CBNumber:
- CB2973067
- Molecular Formula:
- C21H18O4
- Molecular Weight:
- 334.37
- MDL Number:
- MFCD06798350
- MOL File:
- 724709-68-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335-H413 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
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PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P9872 | Psora-4 ≥98% (HPLC) | 724709-68-6 | 5mg | $215 | 2022-05-15 | Buy |
Cayman Chemical | 28389 | Psora 4 | 724709-68-6 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 28389 | Psora 4 | 724709-68-6 | 25mg | $533 | 2024-03-01 | Buy |
Cayman Chemical | 28389 | Psora 4 | 724709-68-6 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 28389 | Psora 4 | 724709-68-6 | 10mg | $230 | 2024-03-01 | Buy |
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Chemical Properties,Uses,Production
Description
Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).
Uses
Psora-4 is the most potent small-molecule Kv1.3 blocker known. Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorders.
Definition
ChEBI: Psora 4 is a member of the class of psoralens that is psoralen substituted by a 4-phenylbutoxy group at position 5. It is a potent inhibitor of the voltage-gated potassium channel Kv1.3 (EC50 = 3 nM). It has a role as a geroprotector, a potassium channel blocker and an immunosuppressive agent. It is a member of benzenes, an aromatic ether and a member of psoralens.
Biochem/physiol Actions
The lymphocyte potassium channel Kv1.3 is regarded as a new target for immunosuppression. Psora-4 is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. It exhibited 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM) and showed no effect on human ether-a-go-go-related channel, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel. In a test of in vivo toxicity in rats, Psora-4 did not display any signs of acute toxicity after five daily subcutaneous injections at 33 mg/kg body weight. Psora-4 selectively suppressed the proliferation of human and rat myelin-specific effector memory T cells with EC50 values of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells. Because autoantigen-specific effector memory T cells contribute to the pathogenesis of T cell-mediated autoimmune diseases such as multiple sclerosis, Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disord.
in vitro
psora-4 could block kv1.3 in a dose-dependent manner. psora-4 was found to be the most potent small-molecule kv1.3 blocker known. psora-4 exhibited 17- to 70-fold selectivity for kv1.3 over kv1-family channels including kv1.1, kv1.2, kv1.4, and kv1.7 and also showed no effect on human ether-a-go-go-related channel, kv3.1, or the neuronal nav1.2 channel. in addition, psora-4 could suppress the proliferation of rat and human myelin-specific effector memory t cells with ec50 values of 60 and 25 nm, respectively, without persistently suppressing the peripheral blood naive and central memory t cells [1].
in vivo
in a study of in vivo toxicity in rats, psora-4 was found not to show any signs of acute toxicity following five daily subcutaneous injections at 33 mg/kg body weight [1].
storage
Store at -20°C
References
[1] vennekamp j,wulff h,beeton c,calabresi pa,grissmer s,hnsel w,chandy kg. kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. mol pharmacol.2004 jun;65(6):1364-74.
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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