ChemicalBook >> CAS DataBase List >>1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)- structure

CAS No.: 2253744-56-6

Chemical Name:: 1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-

Synonyms: 7-((5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,3-dimethyl-8-(piperazin-1-yl)-3,7-dihydro-1H-purine-2,6-dione;TH5427,inhibit,breast cancer,proliferation,Inhibitor,TH 5427,NUDT5,ATP synthesis,TH-5427,progestin-dependent,ADP-ribose;1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)-

CBNumber:: CB29742336

Molecular Formula:: C20H20Cl2N8O3

Molecular Weight:: 491.33

MDL Number:

MOL File:: 2253744-56-6.mol

Last updated:2023-05-21 10:59:17

Request For Quotation

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)- Properties

Boiling point	717.2±70.0 °C(Predicted)
Density	1.68±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
pka	8.51±0.10(Predicted)

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)- Chemical Properties,Uses,Production

Biological Activity

TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].

References

[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3444	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	997	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	61720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	2853979810@qq.com	China	9729	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Henan Alpha Chemical Co., Ltd.	58

1H-Purine-2,6-dione, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-3,7-dihydro-1,3-dimethyl-8-(1-piperazinyl)- TH5427,inhibit,breast cancer,proliferation,Inhibitor,TH 5427,NUDT5,ATP synthesis,TH-5427,progestin-dependent,ADP-ribose 7-((5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-1,3-dimethyl-8-(piperazin-1-yl)-3,7-dihydro-1H-purine-2,6-dione 2253744-56-6 C20H20Cl2N8O3