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Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-

CAS No.
2387821-46-5
Chemical Name:
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-
Synonyms
HB007;HB-007,HB007;1-(3-Chlorophenyl)-3-(6-cyanobenzo[d]thiazol-2-yl)urea;Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-
CBNumber:
CB29783269
Molecular Formula:
C15H9ClN4OS
Molecular Weight:
328.78
MDL Number:
MFCD34578507
MOL File:
2387821-46-5.mol
Last updated:2024-10-28 16:48:35

Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Properties

Density 1.51±0.1 g/cm3(Predicted)
pka 7.16±0.70(Predicted)
form Solid
color Light yellow to yellow

Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Chemical Properties,Uses,Production

Biological Activity

HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2]. HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1]. HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].

References

[1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. [2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.

Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
support@targetmol.com United States 38463 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 sales@shydchem.com.cn China 982 56
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9410 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24649 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 4997 58

View Lastest Price from Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HB007 pictures 2024-10-28 HB007
2387821-46-5
US $1110.00-1610.00 / mg 10g TargetMol Chemicals Inc.
  • HB007 pictures
  • HB007
    2387821-46-5
  • US $1110.00-1610.00 / mg
  • TargetMol Chemicals Inc.
Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)- HB007 HB-007,HB007 1-(3-Chlorophenyl)-3-(6-cyanobenzo[d]thiazol-2-yl)urea 2387821-46-5