Cyn 154806 trifluoroacetate
- CAS No.
- 2828432-46-6
- Chemical Name:
- Cyn 154806 trifluoroacetate
- Synonyms
- Cyn 154806 trifluoroacetate
- CBNumber:
- CB310080455
- Molecular Formula:
- C58H69F3N12O16S2
- Molecular Weight:
- 1311.37
- MDL Number:
- MOL File:
- 2828432-46-6.mol
Cyn 154806 trifluoroacetate Chemical Properties,Uses,Production
Uses
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2].
in vivo
CYN 154806 TFA (0.1 mg/kg; i.p.; 20 min before the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice[3].
IC 50
SSTR2
References
[1] Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15. PMID:8863814
[2] Feniuk W, et al. Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology. 2000 Jun 8;39(8):1443-50. DOI:10.1016/s0028-3908(00)00035-6
[3] Takeuchi K, et al. Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin. Front Pharmacol. 2016 Aug 30;7:278. DOI:10.3389/fphar.2016.00278
Cyn 154806 trifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Cyn 154806 trifluoroacetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38659 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7062 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39665 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24843 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6628 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 4997 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 48813 | 58 |
View Lastest Price from Cyn 154806 trifluoroacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-18 | CYN 154806 TFA
2828432-46-6
|
US $147.00-689.00 / mg | 99.7% | 10g | TargetMol Chemicals Inc. |
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- CYN 154806 TFA
2828432-46-6
- US $147.00-689.00 / mg
- 99.7%
- TargetMol Chemicals Inc.