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ChemicalBook >> CAS DataBase List >>2, 4-DICHLORO-5-IODOPYRIMIDINE

2, 4-DICHLORO-5-IODOPYRIMIDINE

2, 4-DICHLORO-5-IODOPYRIMIDINE Structure
2, 4-DICHLORO-5-IODOPYRIMIDINE structure
CAS No.
13544-44-0
Chemical Name:
2, 4-DICHLORO-5-IODOPYRIMIDINE
Synonyms
2,4-Dichloro-5-iodopyrimidine;GS-5894;oro-5-iodopyrimidine;2, 4-dichloro-5-iodimidine;5-Iodo-2,4-dichloropyrimidine;2,4-Dichloro-5-iodo-1,3-diazine;Pyrimidine, 2,4-dichloro-5-iodo-;2,4-Dichloro-5-iodopyrimidine>2,4-Dichloro-5-iodopyrimidine 95%;2,4-Dichloro-5-iodopyriMidine, 95+%
CBNumber:
CB31009832
Molecular Formula:
C4HCl2IN2
Molecular Weight:
274.87
MDL Number:
MFCD01898087
MOL File:
13544-44-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:54:01
Product description Number Pack Size Price
2,4-Dichloro-5-iodopyrimidine 95% 706566 1g $63.5
2,4-Dichloro-5-iodopyrimidine >98.0%(GC) D4122 1g $22
2,4-Dichloro-5-iodopyrimidine >98.0%(GC) D4122 5g $71
2,4-DICHLORO-5-IODO-PYRIMIDINE 97% 60382 5G $12
2,4-DICHLORO-5-IODO-PYRIMIDINE 97% 60382 25G $38
More product size
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2, 4-DICHLORO-5-IODOPYRIMIDINE Properties

Melting point 68.0 to 72.0 °C
Boiling point 310.2±22.0 °C(Predicted)
Density 2+-.0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility soluble in Methanol
form powder to crystal
pka -4.19±0.29(Predicted)
color White to Gray to Brown
InChI 1S/C4HCl2IN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChIKey RGJNPJRAXMSHKN-UHFFFAOYSA-N
SMILES Clc1ncc(I)c(Cl)n1
CAS DataBase Reference 13544-44-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H315-H318-H335
Precautionary statements  P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
RIDADR  2811
WGK Germany  3
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  29335990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2, 4-DICHLORO-5-IODOPYRIMIDINE price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 706566 2,4-Dichloro-5-iodopyrimidine 95% 13544-44-0 1g $63.5 2026-04-30 Buy
TCI Chemical D4122 2,4-Dichloro-5-iodopyrimidine >98.0%(GC) 13544-44-0 1g $22 2026-04-30 Buy
TCI Chemical D4122 2,4-Dichloro-5-iodopyrimidine >98.0%(GC) 13544-44-0 5g $71 2026-04-30 Buy
AstaTech 60382 2,4-DICHLORO-5-IODO-PYRIMIDINE 97% 13544-44-0 5G $12 2026-04-30 Buy
AstaTech 60382 2,4-DICHLORO-5-IODO-PYRIMIDINE 97% 13544-44-0 25G $38 2026-04-30 Buy
Product number Packaging Price Buy
706566 1g $63.5 Buy
D4122 1g $22 Buy
D4122 5g $71 Buy
60382 5G $12 Buy
60382 25G $38 Buy

2, 4-DICHLORO-5-IODOPYRIMIDINE Chemical Properties,Uses,Production

Chemical Properties

Off-white powder

Uses

2,4-Dichloro-5-iodopyrimidine can be used as a reagent to synthesize dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrimidine VLA-4 antagonists.

Synthesis

5-Iodouracil

696-07-1

2, 4-DICHLORO-5-IODOPYRIMIDINE

13544-44-0

The general procedure for the synthesis of 2,4-dichloro-5-iodopyrimidine from 5-iodouracil is as follows: 1. Preparation of intermediate 1: 2,4-dichloro-5-iodopyrimidine - To a suspension of N,N-dimethylaniline (11.0 mL) in 5-iodouracil (10.0 g, 42 mmol), phosphorus oxychloride (POCl3, 64.4 g, 39.2 mL, 420 mmol) was added. - The reaction mixture was heated to 90 °C and stirred at this temperature for 90 min. - After the reaction was completed, it was cooled to room temperature and the excess POCl3 was removed by evaporation. - The residue was slowly poured into an ice-water mixture and stirred for 2 h. The crystalline precipitate was collected by filtration and washed with cold water. - The crude product was dissolved in ethyl acetate and extracted sequentially with aqueous sodium bicarbonate and aqueous sodium sulfite. - The organic phase was dried with anhydrous sodium sulfate, filtered and the solvent was evaporated. - The residue was purified by column chromatography to afford 2,4-dichloro-5-iodopyrimidine (10.6 g, 92% yield). The structure of the product was determined by 1H-NMR. - The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 8.90 (s, 1H).

References

[1] Patent: EP1878726, 2008, A1. Location in patent: Page/Page column 32
[2] Patent: WO2007/71455, 2007, A1. Location in patent: Page/Page column 146
[3] Patent: US2007/232632, 2007, A1. Location in patent: Page/Page column 55; 56
[4] Patent: WO2008/155140, 2008, A1. Location in patent: Page/Page column 108
[5] Tetrahedron, 2000, vol. 56, # 27, p. 4777 - 4792

2, 4-DICHLORO-5-IODOPYRIMIDINE Preparation Products And Raw materials

Raw materials

5-Iodouracil

Preparation Products

2, 4-DICHLORO-5-IODOPYRIMIDINE Suppliers

Global( 331)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20121 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2165 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Changzhou Ditong Chemical Co.,Ltd 		58

View Lastest Price from 2, 4-DICHLORO-5-IODOPYRIMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2, 4-DICHLORO-5-IODOPYRIMIDINE pictures 2026-07-09 2, 4-DICHLORO-5-IODOPYRIMIDINE
13544-44-0
 $1.50-36.00 1kg 99% Henan Fengda Chemical Co., Ltd
2,4-Dichloro-5-iodopyrimidine pictures 2026-04-21 2,4-Dichloro-5-iodopyrimidine
13544-44-0
 10g TargetMol Chemicals Inc.
2, 4-DICHLORO-5-IODOPYRIMIDINE pictures 2025-11-18 2, 4-DICHLORO-5-IODOPYRIMIDINE
13544-44-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited

2, 4-DICHLORO-5-IODOPYRIMIDINE Spectrum

2, 4-DICHLORO-5-IODOPYRIMIDINE(13544-44-0)1HNMR2, 4-DICHLORO-5-IODOPYRIMIDINE(13544-44-0)FT-IR

13544-44-0(2, 4-DICHLORO-5-IODOPYRIMIDINE)Related Search:

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5-Iodo-2,4-dichloropyrimidine 2,4-Dichloro-5-iodo-1,3-diazine 2,4-Dichloro-5-iodopyriMidine, 95+% Pyrimidine, 2,4-dichloro-5-iodo- 2,4-Dichloro-5-iodopyrimidine 95% 2,4-Dichloro-5-iodopyrimidine> oro-5-iodopyrimidine 2, 4-DICHLORO-5-IODOPYRIMIDINE ISO 9001：2015 REACH 2, 4-dichloro-5-iodimidine GS-5894 2,4-Dichloro-5-iodopyrimidine, CAS 13544-44-0 2,4-Dichloro-5-iodopyrimidine 13544-44-0 3544-44-0 Halides Pyrazines, Pyrimidines & Pyridazines pharmacetical Organohalides Pyrimidine Pyrimidines Pyrimidine series Heterocycle-Pyrimidine series