VILAZODONE
- CAS No.
- 163521-12-8
- Chemical Name:
- VILAZODONE
- Synonyms
- CS-108;AK-Con;All Clear;Vilozodone;VILAZODONE;EMD 515259;Clear Eyes;Vilazodonei;Vilazodone-d6;Vilazodone HCL
- CBNumber:
- CB31011682
- Molecular Formula:
- C26H27N5O2
- Molecular Weight:
- 441.52
- MDL Number:
- MFCD09838919
- MOL File:
- 163521-12-8.mol
- MSDS File:
- SDS
Melting point | 203-205°C |
---|---|
Boiling point | 745.1±60.0 °C(Predicted) |
Density | 1.34±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO (Slightly)), Methanol (Slightly) |
pka | 15.98±0.30(Predicted) |
form | Solid |
color | Pale Yellow to Beige |
Stability | Very Hygroscopic |
CAS DataBase Reference | 163521-12-8 |
FDA UNII | S239O2OOV3 |
ATC code | N06AX24 |
VILAZODONE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | V265000 | Vilazodone | 163521-12-8 | 250mg | $295 | 2021-12-16 | Buy |
ChemScene | CS-0550 | Vilazodone 99.91% | 163521-12-8 | 50mg | $396 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | D34392 | Vilazodone-d8HCl | 163521-12-8 | 1mg | $675 | 2021-12-16 | Buy |
Matrix Scientific | 094760 | 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide 95+% | 163521-12-8 | 250mg | $681 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008118 | VILAZODONE 95.00% | 163521-12-8 | 10MG | $697.2 | 2021-12-16 | Buy |
VILAZODONE Chemical Properties,Uses,Production
Description
Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo.
References
https://www.drugbank.ca/drugs/DB06684
https://en.wikipedia.org/wiki/Vilazodone
http://www.rxlist.com/viibryd-drug/indications-dosage.htm
Description
In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC50=0.2 nM) with high affinity for 5-HT1A receptors (IC50=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.
Chemical Properties
Light Yellow Solid
Originator
Merck KGaA (Germany)
Uses
Labelled analogue of Vilazodone
Uses
It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
Uses
An inhibitor of ST and activator of SR-1A
Definition
ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.
brand name
Viibryd
VILAZODONE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21700 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
View Lastest Price from VILAZODONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-05-04 | Vilazodone
163521-12-8
|
US $48.00-40.00 / KG | 1KG | 99% | 2tons | Guangzhou Sunton Biotechnology Co., Ltd. | ||
2021-07-27 | VILAZODONE USP/EP/BP
163521-12-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | ||
2021-07-13 | vilazodone
163521-12-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Vilazodone
163521-12-8
- US $48.00-40.00 / KG
- 99%
- Guangzhou Sunton Biotechnology Co., Ltd.
- VILAZODONE USP/EP/BP
163521-12-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
- vilazodone
163521-12-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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