ChemicalBook >> CAS DataBase List >>3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-
3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-
- CAS No.
- 2654075-94-0
- Chemical Name:
- 3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-
- Synonyms
- CDK7/12-IN-1;3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-
- CBNumber:
- CB310386252
- Molecular Formula:
- C25H34N8O
- Molecular Weight:
- 462.59
- MDL Number:
- MOL File:
- 2654075-94-0.mol
Last updated:2024-07-02 08:55:04
3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Properties
Density | 1.37±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Store at -20°C |
solubility | DMSO : 100 mg/mL (216.17 mM; Need ultrasonic) |
form | Solid |
pka | 14.69±0.40(Predicted) |
color | White to light brown |
3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Chemical Properties,Uses,Production
Biological Activity
CDK7/12-IN-1 is a selective CDK7/12 inhibitor with IC50s of 3 and 277 nM for CDK7 and CDK 12, respectively. CDK7 and CDK12 inhibition is an effective strategy to inhibit tumour growth[1].
References
[1]. Edward AINSCOW, et al. 4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds and their therapeutic use. WO2021122745A1.
3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 4997 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
Supplier | Advantage |
---|---|
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
TargetMol Chemicals Inc. | 58 |
3-Piperidinol, 4-[[[7-[[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methyl]amino]-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-
CDK7/12-IN-1
2654075-94-0