BIM187
- CAS No.
- 137734-88-4
- Chemical Name:
- BIM187
- Synonyms
- BIM187;1-Phe-8-Leu-9-Leu-litorin-NH2;L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- (9CI)
- CBNumber:
- CB31073336
- Molecular Formula:
- C53H76N14O10
- Molecular Weight:
- 1069.26
- MDL Number:
- MFCD09753288
- MOL File:
- 137734-88-4.mol
BIM187 price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Usbiological | 254759 | BIM 187 | 137734-88-4 | 1mg | $466 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | PEP0004452 | BIM 187 95.00% | 137734-88-4 | 5MG | $500.96 | 2021-12-16 | Buy |
ApexBio Technology | B5330 | BIM187 | 137734-88-4 | 1mg | $314 | 2021-12-16 | Buy |
BIM187 Chemical Properties,Uses,Production
Biological Activity
bombesin has common effects on the gastrointestinal tract and feeding behavior. bombesin acts on two types of receptors including one with high affinity for neuromedin b and another with high affinity for bombesin and gastrin-releasing peptide (grp). bim 187is a new peptide of bombesin while bim 189 is a potent bombesin antagonis.
in vitro
bombesin stimulates mainly the bombesin high-affinity receptor, and bim 187 ([d-phe i ,leu 8'9 ]litorin-nhe), a new bombesin agonist, stimulates the bombesin/grp receptor type. [2].
in vivo
to study the mechanism by which bombesin induces satiety, we studied the effect of bim187 on food intake in rats fed 6 h a day. bim 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. bim 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). bim 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by bim 187 [2].
References
[1] coy d, wang lh, jiang ny, jensen r. short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. eur j pharmacol. 1990 nov 6;190(1-2):31-8.
[2] laferrère b, leroy f, bonhomme g, le gall a, basdevant a, guy-grand b. effects of bombesin, of a new bombesin agonist (bim187) and a new antagonist (bim189) on food intake in rats, in relation to cholecystokinin. eur j pharmacol. 1992 apr 29;215(1):23-8.
BIM187 Preparation Products And Raw materials
Raw materials
Preparation Products
BIM187 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4862 | 58 |
Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6757 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6445 | 58 |
Shanghai HongTide Biotechnology Co.,Ltd. | 19961912513 | sales@hongtide.com | China | 4561 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4678 | 58 |
United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |